Amanda Strickland

59th Medical Wing

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Hao Chen

Southwestern Medical Center

Wenxin Zheng

The University of Texas Southwestern Medical Center

Diego H. Castrillón

The University of Texas Southwestern Medical Center

Elena Lucas

The University of Texas Southwestern Medical Center

Katja Gwin

Southwestern Medical Center

Kyle Molberg

The University of Texas Southwestern Medical Center

Feng Zhou

Zhejiang University

Timothy J. C. Anderson

Texas Biomedical Research Institute

Shuang Niu

Southwestern Medical Center

Winka Le Clec’h

Texas Biomedical Research Institute

Cooperative Institutions

The University of Texas Southwestern Medical Center

Northwestern University

Southwestern Medical Center

Texas Biomedical Research Institute

Northwestern Memorial Hospital

Women's Hospital, School of Medicine, Zhejiang University

National Institutes of Health

Parkland Memorial Hospital

The University of Texas Health Science Center at San Antonio

Parkland Health & Hospital System

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Abbott ARCHITECT Syphilis TP Chemiluminescent Immunoassay Accurately Diagnoses Past or Current Syphilis in Pregnancy

American Journal of Perinatology (2020)

Emily H. Adhikari I. J. Frame Emilie Hill Rizwana Fatabhoy Amanda Strickland

Abstract Objective We evaluate diagnostic accuracy of the ARCHITECT chemiluminescent immunoassay (CIA) screening test in pregnancy, and evaluate pregnancy outcomes among screen-positive women. Study Design Samples from routine prenatal rapid plasma reagin (RPR) tests were collected between June 22 and August 18, 2017 and frozen. Samples were batch-tested with the Abbott ARCHITECT syphilis TP immunoassay (CIA, index test). We calculated sensitivity, specificity, predictive value, and false positivity. We compared pregnancy and neonatal outcomes among screen-positive women. Results Of 1,602 specimens, 35 (2.2%) were RPR + ; of those, 24 (69%) were CIA +/Treponema pallidum particle agglutination assay (TPPA)+ and 11 (31%) were CIA-/TPPA-. Of 1,567 RPR- specimens, 14 (0.9%) were CIA + ; of those, 13 (93%) were TPPA + , and one (7%) had a false positive CIA test. Sensitivity of the CIA (95% CI) was 100% (90.5–100%), specificity 99.9% (99.6–100%), positive predictive value 97.4% (86.2–99.9%), and false positive rate 0.06% (0.002–0.4%) for current or past syphilis. Among 37 CIA +/TPPA+ women, seven (19%) had RPR-negative status (Group 1), 11 (30%) had previously treated syphilis (Group 2), and 19 (51%) had active infection (Group 3). One stillbirth occurred in a woman with early, active syphilis identified at delivery; no adverse perinatal outcomes occurred among women in Groups 1 or 2. Conclusion The ARCHITECT syphilis TP immunoassay accurately diagnoses current or past syphilis in pregnancy. Clinical history and staging remain essential using a reverse algorithm.

Rapid plasma reagin

Chemiluminescent immunoassay

10.1055/s-0039-3400994

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"Sounding white": African-American attitudes toward "whiteness" in the speech of African-Americans

Amanda Strickland

White (mutation)

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Borderline With Bad Behavior: An Unusual Low-grade Serous Carcinoma With Dedifferentiation From a Serous Borderline Tumor

International Journal of Gynecological Pathology (2023)

Amanda Strickland Kruti P. Maniar Edward J. Tanner Elisheva D. Shanes Lawrence J. Jennings

The pathogenesis of serous ovarian tumors has been extensively investigated, with a dualistic model dividing these cancers into 2 groups. Type I tumors, including low-grade serous carcinoma, is characteristic for concurrent presence of borderline tumors, less atypical cytology, relatively indolent biologic behavior, and molecular aberrations related to the MAPK pathway with chromosomal stability. Meanwhile, type II tumors, such as high-grade serous carcinoma, are notable for no significant association with borderline tumors, higher grade cytology, more aggressive biologic behavior, and TP53 mutations along with chromosomal instability. We describe a case of morphologic low-grade serous carcinoma with focally increased cytologic atypia arising in serous borderline tumors involving both ovaries, which demonstrated highly aggressive behavior despite several years of surgical and chemotherapeutic management. Each recurrent specimen contained more uniform higher grade morphology than what was seen in the original specimen. Immunohistochemical and molecular studies in both the original tumor and the most recent recurrence demonstrate identical mutations in the MAPK genes, but with additional mutations in the latter, notably an acquisition of a variant of possible clinical significance in the SMARCA4 gene, which is associated with dedifferentiation and aggressive biologic behavior. This case challenges our current and still evolving understanding of the pathogenesis, biologic behavior, and expected clinical outcome of low-grade serous ovarian carcinomas. It also underscores the need for further investigation into this complicated tumor.

Serous carcinoma

Atypia

Hematopathology

10.1097/pgp.0000000000000885

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Human Papillomavirus (HPV)

Springer eBooks (2014)

Amanda Strickland Gabriela Blanco

Etiology

Histopathology

10.1007/978-3-642-54446-0_34

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Primary HPV-Associated Enteric-Type Adenocarcinoma of Vagina: A Case Report

International Journal of Surgical Pathology (2023)

Christopher Felicelli Amanda Strickland Jian‐Jun Wei

Primary enteric type adenocarcinomas of the vagina are extremely rare. We present a 63-year-old woman who had a polypoid mass localized to the distal vagina. The lesion was composed of a columnar glandular cell proliferation with focal cribriforming, reminiscent of tubular adenoma. Immunohistochemical stains were notable for expression of enteric markers (CDX2 and KRT20), as well as negativity for Mullerian markers (PAX8, ER, and PR), diffuse expression for p16, and positivity for high-risk HPV mRNA expression. Ultimately, a diagnosis of vaginal primary HPV-associated enteric type adenocarcinoma was rendered for this unusual lesion. To our knowledge, no prior cases of HPV-associated enteric type adenocarcinomas of the vagina have been described before.

PAX8

10.1177/10668969221150529

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A Single Center Retrospective Analysis of Outcomes Following the Use of 4-Factor Prothrombin Complex Concentrate for Warfarin Reversal in Real-Life Settings

Blood (2014)

Ranjit Joseph Amanda Strickland James Burner Sean G. Yates William Tharpe

Prothrombin complex concentrate

Single Center

Vitamin K antagonist

10.1182/blood.v124.21.1561.1561

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EXPLORATORY TYMPANOCENTESIS FOR THE DIAGNOSIS OF ACUTE OTITIS MEDIA WITH EFFUSION IN THE NEONATE: LIMITATIONS IN THE USE OF THE TYMPANOMETER UNDER SEVEN MONTHS OF AGE

Pediatric Research (1987)

Virgil M. Howie Mary L Grabowski John H. Ploussard Amanda Strickland

Tympanometry

Acute Otitis Media

10.1203/00006450-198704010-00698

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Pediatric vulvar malignancies: rare but important to know

Seminars in Diagnostic Pathology (2020)

Amanda Strickland Oluwole Fadare

Immunosuppression

10.1053/j.semdp.2020.09.001

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Citations (12)

Neoplasms

Plastic & Reconstructive Surgery (1969)

Amanda Strickland Jefferys A. Macfie Judson J. Van Wyk Frank S. French

10.1097/00006534-196909000-00032

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HHV-8-associated haemophagocytic lymphohistiocytosis in a patient with advanced AIDS

BMJ Case Reports (2017)

Saroja Bangaru Amanda Strickland Dominick Cavuoti Nainesh Shah

We present a patient with advanced AIDS admitted with recurrent shock of unclear aetiology, fevers, altered mental status and refractory cytopenias. His case posed a diagnostic challenge because evaluation of septic shock in the setting of advanced AIDS requires a time-consuming work-up for broad infectious aetiologies that can delay consideration of other diagnoses, including primary or secondary haemophagocytic lymphohistiocytosis (HLH). After this patient did not improve with supportive care and empiric antimicrobials, there was concern for HLH given that he met ≥5 of the HLH consortium criteria. He underwent bone marrow biopsy, which was non-diagnostic. Empiric therapy for HLH was initiated, but unfortunately, the patient died. Autopsy revealed extensive haemophagocytosis in the spleen, bone marrow and liver, confirming the diagnosis of HLH. Postmortem, his soluble CD-25 returned 18 890 pg/mL (<1033 pg/mL), and his serum HHV-8 PCR resulted positive. The diagnosis was HLH secondary to Human Herpes Virus 8 (HHV-8) in a patient with advanced AIDS.

Empiric therapy

Etiology

10.1136/bcr-2017-222382

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Citations (6)