Abstract Reversible histone acylation is crucial for epigenetic gene expression regulation. Histone acylation is typically mediated by lysine acyltransferases (KATs), which use acyl-CoAs as acyl donors. Here, we revealed the novel role of the histone deacetylases HDAC1 and HDAC2 in histone acylation catalysis. Notably, we show that HDAC1 and HDAC2 directly catalyze sorbylation using sorbic acid, a common food preservative, in addition to facilitating desorbylation. This newly discovered HDAC1/2-driven histone sorbylation function is a distinctive active epigenetic mark that leads to widespread changes in the expression of genes, particularly those involved in cholesterol biosynthesis. Our findings reveal that HDAC1/2 are unique enzymes capable of catalyzing not only the removal but also formation of histone modifications in response to exogenous carboxylic acids such as sorbic acid and benzoic acid. Our results highlight the impact of carboxylic acids found in the environment, such as food additives, on gene expression changes that occur via histone lysine modification regulated by HDAC1 and HDAC2.
Ein Katalysator für zwei Aktivierungen: Kationische Pd- und Pt-Komplexe katalysieren die enantioselektive Aldolreaktion von β-Ketoestern mit Acetalen (siehe Schema). Wegen der Bildung von Metallenolaten unter sauren Bedingungen können die Acetale als Elektrophile eingesetzt werden. Die gewünschten Aldolprodukte entstehen hoch diastereo- und enantioselektiv. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2001/2008/z705344_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
The asymmetric fluorination of β-keto carbonyl compounds has attracted interest due to the enhanced pharmaceutical activity of F-containing compounds. Here, the enantioselective electrophilic fluorination of aryl acetic acid derivatives is reported and can afford after cleavage of the thiooxazolidinone moiety chiral α-monofluorinated carboxylic acids without loss of stereochemical information (see reviews below).
Zwei sind nicht genug: Das binäre System aus einem Ni(OTf)2-Binap-Komplex und 2,6-Lutidin war ungeeignet für die asymmetrische Fluorierung von Esteräquivalenten, auf Zusatz einer substöchiometrischen Menge an Et3SiOTf katalysierte das System NiCl2-Binap/2,6-Lutidin hingegen die Bildung der monofluorierten Produkte in guten Ausbeuten und mit hohen Enantioselektivitäten (siehe Beispiel). NFSI=N-Fluorbenzolsulfonimid, Tf=Trifluormethansulfonyl.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStereospecific synthesis of exo-trisubstituted olefins. The highly efficient synthesis of carbacyclinsMasakatsu Shibasaki, Mikiko Sodeoka, and Yuji OgawaCite this: J. Org. Chem. 1984, 49, 21, 4096–4098Publication Date (Print):October 1, 1984Publication History Published online1 May 2002Published inissue 1 October 1984https://pubs.acs.org/doi/10.1021/jo00195a056https://doi.org/10.1021/jo00195a056research-articleACS PublicationsRequest reuse permissionsArticle Views169Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
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