Somanaboina Padmakar

Narayana Dental College and Hospital

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Sweta Kumari

University College of Medical Sciences

Biplab Pal

Lovely Professional University

Krishna Murti

National Institute of Pharmaceutical Education and Research

Niyamat Ali Siddiqui

Rajendra Memorial Research Institute of Medical Sciences

Rishikesh Kumar

Rajendra Memorial Research Institute of Medical Sciences

Biplab Pal

Lovely Professional University

Krishna Murari Pandey

Rajendra Memorial Research Institute of Medical Sciences

Settipalli Anusha

Government Medical College

V. Wazeed Basha

Valluru Wazeed Basha

Dr. Reddy's Laboratories (United States)

Cooperative Institutions

Lovely Professional University

Rajendra Memorial Research Institute of Medical Sciences

Indian Council of Medical Research

All India Institute of Medical Sciences

National Institute of Pharmaceutical Education and Research

Dr. Reddy's Laboratories (United States)

Yale University

All India Institute of Medical Sciences Bhopal

Indira Gandhi Institute of Medical Sciences

Vardhman Mahavir Medical College & Safdarjung Hospital

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Diabetes Mellitus and the Possibility of Developing Dementia

Asian Journal of Pharmaceutical Research and Development (2021)

S. Nelson Kumar V. Wazeed Basha C. Sireesha G. Jacob Gnanaprakasam M. Pavan Kalyan

Background: Dementia and cognitive dysfunction have many causes. There is strong evidence that diabetes mellitus (DM) increases the risk of cognitive impairment and dementia. A prophylactic approach, optimal glycaemic control, and identification of diabetic risk factors are essential to preventing cognitive complications. Objective: The main objectives of this study are to assess the severity of dementia by using the Clinical Dementia Rating scale (CDR), and the effect of longevity of diabetes mellitus on the severity of dementia. Method: It is a Hospital-based prospective observational study, in which the patients were enrolled into the study after taking an informed consent form from them based on the inclusion and exclusion criteria. Results: Out of 80 patients, 62(77.5%) were suffering with dementia and 18(22.5%) were found to be normal. The diabetes patients included in this study had a duration of diabetes ranges from 6 to 30 years. Using the CDR scale, 24 of them (30%) were diagnosed with moderate dementia. Conclusion: According to our findings, we emphasize the need to consider DM as a potential risk factor for dementia.

Clinical Dementia Rating

10.22270/ajprd.v9i5.1004

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Citations (1)

A Study on Drug Prescribing Patterns in Vitiligo Patients of Andhra Pradesh in a Tertiary Care Teaching Hospital.

PubMed (2024)

Somanaboina Padmakar Sweta Kumari Biplab Pal

Vitiligo is a dermatological condition characterized by the appearance of white spots or patches on the skin due to the loss of skin pigment called melanocytes. The estimated prevalence of vitiligo is about 0.5-2% of the world population, but in India, the prevalence rate varies from 2 to 8%, depending on the region. This study aimed to assess drug prescribing patterns in vitiligo patients.

Vitiligo

Tertiary care

10.59556/japi.72.0527

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Efficacy and safety of natural Aloe Vera gel in the treatment of stable vitiligo

Clinical Epidemiology and Global Health (2023)

Somanaboina Padmakar G. Ajay Kumar Navneet Khurana Sweta Kumari Biplab Pal

Abstract

Background

Vitiligo is a condition that causes a patchy loss of skin pigmentation. The Aloe Vera plant has been used to treat a wide range of ailments, including skin diseases; however, little is known about its effectiveness in vitiligo. This study aimed to assess the efficacy and safety of natural Aloe Vera in stable vitiligo.

Methods

A retrospective review of medical records was conducted on vitiligo patients who recommended natural Aloe Vera between July 2021 and August 2022. All patients were advised to apply natural Aloe Vera leaf pulp thrice daily for 6 months, along with sunlight exposure. Efficacy was measured as the proportion of patients achieving ≥75% re-pigmentation of the target lesion at the end of 24 weeks, which constituted a "good response," while 50% or higher re-pigmentation constituted a "better response." The extent of re-pigmentation was assessed as per the protocol and graded from 0 to 5. Safety was assessed as the proportion of patients reporting ≥1 adverse event at 24 weeks.

Results

The results revealed that 19 (86.3%) patients responded positively after receiving 3 months of treatment: 4 patients repigmented 50–74%, 8 patients repigmented 25–49%, 7 patients repigmented 1–24%, and 3 patients didn't repigment at all. After completion of 6 months of therapy, 3 patients repigmented 75–99%, 4 patients repigmented 50–74%, 10 patients repigmented 25–49%, 2 patients repigmented 1–24%, and 3 patients didn't show any change in re-pigmentation. Only 2 (9%) patients showed 90% re-pigmentation (grade 6) at the end of the study. Stinging or burning sensations and pruritus were experienced by 3 patients within the first week of treatment.

Conclusion

Natural Aloe Vera was found to be safe and fairly effective in the treatment of stable vitiligo. However, randomized controlled trials with larger sample size are recommended to verify the efficacy and safety of Aloe Vera in the treatment of vitiligo.

Vitiligo

Aloe Vera

10.1016/j.cegh.2023.101332

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Suicidal ideation associated with vitiligo - A systematic review of prevalence and assessment

Clinical Epidemiology and Global Health (2022)

Somanaboina Padmakar Krishna Murti Krishna Murari Pandey Sweta Kumari Rishikesh Kumar

BackgroundVitiligo is a chronic dermatological condition associated with an increased risk of psychiatric disorders, including Suicidal Ideation (SI). Therefore, understanding of SI in patients with vitiligo is critically important. This systematic review aimed to investigate the assessment, and prevalence of SI in vitiligo patients.MethodThis systematic review was prepared according to the PRISMA statement. We searched PubMed, Scopus, Google Scholar, and additional sources to find out relevant articles. Study selection, data extraction, and quality assessment were carried out independently by two reviewers. We used the Joanna Briggs Institute critical appraisal checklist tool to assess the methodological quality of the included study.FindingsSix studies involving 516 vitiligo patients were included in the analyses. The prevalence of suicidal ideation ranged from 6% to 25%. Two studies relied on 28 items General Health Questionnaire (GHQ) and the remaining studies used the Hamilton Rating Scale for Depression (HDRS), Beck Depression Inventory (BDI), Quick Inventory of Depressive Symptomatology- Self Report-16 (QIDS-SR-16) and Diagnostic and Statistical Manual of Mental Disorders (DSM-5).ConclusionClinicians should aware that a significant proportion of vitiligo patients are exposed to the risk of suicide. Therefore, it is recommended that vitiligo patients should be screened for suicidal ideation and make appropriate referrals to treat their psychiatric morbidities.

Vitiligo

Critical appraisal

Depression

10.1016/j.cegh.2022.101140

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Evaluation of prevalence, risk factors, and characteristics of epilepsy in children with cerebral palsy

Journal of Dr. YSR University of Health Sciences. (2023)

Somanaboina Padmakar N. Hemanth Kumar Ragiri Saraswathi MurthyKavya Sree Settipalli Anusha

10.4103/jdrntruhs.jdrntruhs_44_23

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“SLURRED SPEECH AND TREMORS RESULTING FROM ANTIPSYCHOTIC THERAPY IN A PATIENT WITH BIPOLAR DISORDER: A CASE REPORT”

Asian Journal of Pharmaceutical and Clinical Research (2021)

Somanaboina Padmakar

Bipolar disorder (BD) is a mood disorder where moods can fluctuate from depression to elevated moods referred to as mania. BD is currently divided into three types. All three types involve clear changes in mood, energy, and activity levels. BD-I is the most severe disorder and symptoms of mania can be so severe that they can require psychiatric hospitalization. BD-II has the same symptoms as BD-I; however, it was described as hypomania because they are less severe than in pure mania. Cyclothymia, also known as a cyclothymic disorder, is a minor mood disorder characterized by fluctuating low-level depressive symptoms and periods of mild mania, similar to BD-II. Mood stabilizers and second-generation antipsychotics are first-line for treating and maintaining a stable mood. This study related to a case report on slurred speech and tremors induced by antipsychotics in a patient suffering from BD.

Hypomania

Depression

10.22159/ajpcr.2021.v14i6.41341

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A Systematic Review on Prevalence and Assessment of Sexual Dysfunction in Vitiligo

Journal of the Association of Physicians of India (2022)

Prodduturu Saikarthik Vesam Harinath Reddy Shaik Mahammed Rafi Valluru Wazeed Basha Somanaboina Padmakar

Vitiligo is a common depigmenting disorder with significant psychosocial consequences. Vitiligo has been associated with psychological disorders such as depression, low self-esteem, anxiety, and sexual dysfunction (SD). In recent years, there is an increase in the number of studies looking into the impact of vitiligo on sexual functions. This systematic review investigates the assessment and prevalence of SD in vitiligo patients.We carried out a systematic search for observational studies on the prevalence of SD in vitiligo patients. The Preferred Reporting Items for Systematic Reviews and Meta-Analyzes (PRISMA) guidelines were used to prepare this systematic review. We searched PubMed, Scopus, Google Scholar, and the Cochrane Library databases.We observed 308 studies for screening. Finally, 12 studies that meet the eligibility criteria were included in this study. The prevalence of SD ranged from 2.7 to 82.0%. Most of the studies used the dermatology life quality index (DLQI) to assess SD. Our findings also show that vitiligo patients were more probably experience symptoms of depression and anxiety, one of the risk factors for SD.Psychological comorbidities are related to a high risk of SD in vitiligo patients. Further prospective longitudinal studies are required to investigate the causal factors for SD in vitiligo patients.

Vitiligo

Depression

10.5005/japi-11001-0116

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Citations (3)

Prevalence of suicidal ideation and associated factors among perinatal women living with HIV: a systematic review and meta-analysis

AIDS Care (2025)

Somanaboina Padmakar Vaibhav Chaudhary Sweta Kumari Deepali Dhir Biplab Pal

Perinatal women living with HIV face increased susceptibility to mental health challenges, including suicidal ideation (SI). This study aimed to determine the prevalence of SI among perinatal women with HIV and identify associated factors. A systematic search was done across PubMed, Embase, Scopus, ScienceDirect, and Google Scholar. Data analysis was executed using R software. Publication bias was assessed via funnel plot and Egger's test, while heterogeneity was investigated using the I2 statistic. A total of 11 studies involving 4329 participants were included. The pooled prevalence of SI was 23.4% (95% CI: 16.3–32.4). Subgroup analysis showed higher prevalence in postnatal women (36.4%) than antenatal women (27.8%), although this difference was not statistically significant. Studies employing the Edinburgh Postnatal Depression Scale reported a higher prevalence (38.9%). Studies published between 2013–2017 showed a higher prevalence (37.6%) compared to those published between 2018–2022 (18.2%). Factors associated with SI included depression during pregnancy or postpartum, unplanned pregnancy, intimate partner violence, undisclosed HIV status, lack of social support, and recent diagnosis of sexually transmitted infections other than HIV. The high prevalence of SI emphasizes the need for mental health screening and interventions. Mental health assessments should be integrated into routine antenatal and postnatal care.

Funnel plot

Depression

10.1080/09540121.2025.2453664

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Barriers to the effective management and prevention of post kala-azar dermal leishmaniasis (PKDL) in the Indian subcontinent

Medical Journal Armed Forces India (2023)

Biplab Pal Sweta Kumari Manpreet Kaur Pankaj Wadhwa Krishna Murti

Indian subcontinent

10.1016/j.mjafi.2023.03.010

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A case report on Alagille syndrome and its clinical features

International Journal of Research in Pharmaceutical Sciences (2021)

Somanaboina Padmakar Sayed Alishar Mohammad Ahamadi Tabasum

Alagille syndrome is a rare, chromosome dominant inherited complex disorder affecting varying organs like the liver, heart, kidneys, skeleton, and brain. lt invariably happens because of Notch signaling pathway defects, primarily as a result of JAG1 mutation (ALGS type 1), but it conjointly occurs seldom because of neurogenic locus notch homolog protein (NOTCH2) mutation (ALGS type 2). The symptoms and severity of Alagille syndrome can vary widely, often in the same family, from person to person. Some people may have mild forms, while others may have more severe forms. Blocking of bile flow from the liver (cholestasis), yellowish discoloration of the skin and mucosal membranes (jaundice), low body weight, and extreme itching (pruritis) are the common symptoms, which often occur within the first three months of life. In this current study, we tend to report a case of 14 years old female child who was hospitalized with characteristic facial features like a broad forehead, yellowish discoloration of sclera and skin, posterior embryotoxon, intense itching, dry, coarse skin, mild splenomegaly, mild hepatomegaly. She conjointly had a history of progressive neonatal jaundice with prominent skin lesions and edema. Therefore our study emphasizes and focuses mainly on understanding and identification of distinct features associated with this syndrome to aid better management in all cases.

Alagille Syndrome

JAG1

Itching

10.26452/ijrps.v12i3.4785

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Citations (1)