H Mehier

Inserm

Author Statistics

Papers

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i-10 index

Research Trends

Author Order

Document Type

Co-Authors

E. Hiltbrand

Cermavein (France)

Jean-Claude Peyrin

Centre Hospitalier Universitaire de Grenoble

P Magnin

University of Geneva

G.J. Béné

University of Geneva

B. Borcard

University of Geneva

A Vasilescu

Grigore T. Popa University of Medicine and Pharmacy

R Moldovanu

Grigore T. Popa University of Medicine and Pharmacy

Hatem Fessi

Université Claude Bernard Lyon 1

J Bélenger

University of Geneva

J Foray

Hôpital de l'Antiquaille

Cooperative Institutions

Université Claude Bernard Lyon 1

Centre National de la Recherche Scientifique

Inserm

University of Geneva

École d'Ingénieurs en Chimie et Sciences du Numérique

Spitalul Clinic Judeţean de Urgenţe "Sf. Spiridon" Iaşi

Grigore T. Popa University of Medicine and Pharmacy

Automation and Process Engineering Laboratory

Hôpital Beau-Séjour

Hôpital Edouard Herriot

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Citation

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Research Field

[Isotope phlebography. Value and limitations. Reliability in recent deep venous thrombosis of the lower limbs (author's transl)].

PubMed (1982)

Xavier Barral H Mehier J. Mallet A. Bonmartin J Descotes

Embolus

PULMONARY EMBOLUS

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Citations (0)

Lung ventilation image by visualisation of the $sup 133$Xe elimination coefficient

H Mehier J.-J. Mallet G Veillas J.P. Cabocel Jean-Claude Peyrin

Lung ventilation

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Low field topical nuclear magnetism apparatus in a hospital area

Magnetic Resonance Imaging (1982)

H Mehier E. Hiltbrand B. Borcard P Magnin G.J. Béné

Magnetism

Precession

10.1016/0730-725x(82)90205-3

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Citations (3)

Application of weak field N.M.R. to human physiological liquid identification

G.J. Béné B. Borcard E. Hiltbrand P Magnin Jacques J. Mallet

Identification

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Citations (0)

Study and realization of a magnetic circuit for in vivo measurement of N.M.R parameters in man on surface organs

H Mehier Jean-Claude Peyrin G.J. Béné B. Borcard E. Hiltbrand

Realization (probability)

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Synthesis and characterization of novel radiopaque poly(allyl amine) nanoparticles

Nanotechnology (2010)

Damia Mawad Antonio Lauto Alexandra Penciu H Mehier Bernard Fenêt

Contrast agents are currently used in a variety of diagnostic imaging techniques, including computer tomography for early cancer detection. Radiopaque nanoparticles have recently been proposed as an alternative method to traditional contrast agents that may allow for long-term image tracking. The aim of this study was the preparation and characterization of aqueous suspensions of radiopaque nanoparticles made of poly(allyl amine) derivatives. Poly(allylamine) (PA) was modified by grafting either 4-iodobenzoyl chloride or 2,3,5-triiodobenzoyl chloride to make the polymer x-ray visible. Nanoparticles of the modified PA were prepared by the nanoprecipitation method and purified with respect to residual organic solvents. Stable suspensions of spherical particles of sub-micronic diameter were characterized by dynamic light scattering and transmission electron microscopy. In addition, the 4.5 wt% suspensions of nanoparticles displayed an x-ray visibility ranging between 185 and 235 HU. The non-clustering ability of the novel PA radiopaque nanoparticles suggests they could be injected via a catheter without clogging or sedimentation.

Allylamine

Characterization

Particle (ecology)

10.1088/0957-4484/21/33/335603

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Citations (13)

In situ Identification of Human Physiological Fluids by Nuclear Magnetism in the Earth's Field

B. Borcard E. Hiltbrand P Magnin G.J. Béné H Mehier

Identification

Magnetism

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Citations (0)

Synergetic Bitherapy in Mice with Xenografts of Human Prostate Cancer Using a Methional Mimic (METLICO) and an Aldehyde Dehydrogenase 3 Inhibitor (MATE): Systemic Intraperitoneal (IP) and Targeted Intra-Tumoral (IT) Administration

Current Medicinal Chemistry (2009)

E. Hiltbrand Guy Fournet J-P. Giliberto M-J. Paret Jacqueline Chantepie

An intraperitoneal (IP) monotherapy in nu/nu mice with subcutaneous xenografts of a human prostate epithelial cancer cell line:DU145 was undertaken with an aldehyde dehydrogenase 3 inhibitor MATE, that is a potent apoptogen on (DU145) in culture but not on their human prostate epithelial normal counterparts [13] . Tumour growth was slowed down but treatment had to be done 5days/week. To try to potentiate the action of MATE in vivo, a bitherapy was undertaken based on the synergetic apoptotic effect that had been observed previously in culture on DU145 treated with a methional mimic METLICO and DIMATE, an inhibitor of ALDH1 and ALDH3 [19]. The bitherapy with METLICO/MATE administered IP was as effective as the monotherapy with MATE alone by IP, but at a 2-fold lower dose of MATE and at a dose of METLICO that had no growth-inhibitory effect as a monotherapy . Hence there was definite synergism with bitherapy. To try to increase the efficacy of bitherapy, it was administered by the intra-tumoral (IT) route using the recently developed 20-bars-pressurized microinjection system from CERMA [16, 17]. IT administration of the bitherapy was indeed more effective than that by IP as regards tumour volumes are concerned. Histopathological analysis of IT-treated tumours confirmed that there were many necrotized zones but intact cells were still present. Approaches for treating a wider zone of tumour tissue by IT-bitherapy are discussed.

DU145

Systemic administration

10.2174/092986709787846596

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Citations (1)

[NMR spectrometry in vivo with a resistive magnet at 1,2 T].

PubMed (1988)

H Mehier M.J. Maurice Bonche Jp Elizabeth R. Gaillard J Foray

A resistive magnet, operating at 1.2 T, intended to magnetic resonance spectroscopy in man was set up and evaluated in the hospital of Chamonix. Drusch S.A. in collaboration with Institut d' Electronique fondamentale built the system with the following characteristics: weight: 12 t, pole diameter: 55 cm, distance between coils: 36 cm. Cooling the magnet was provided by water flowing at 50 l/min. The magnetic field homogeneity was 3 X 10(-7) in a 60 mm diameter sphere. Stability was regulated at +/- 1 mGs. Five correcting circuits were used (X, Y, Z, Z2, XY). For experiments in man useful window was 120 X 20 cm and allowed measurements in brain and limbs. With this type of magnet, 1H, 31P and 23Na NMR spectra equalled in quality those obtained with superconducting magnets which work at a very higher cost.

Resistive touchscreen

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Citations (1)

A new method of thermoablation with hot water vapour for localized tumours.

PubMed (2004)

E. Hiltbrand J Bélenger Tiziano Binzoni Franz Buchegger M. Costa

A new method of thermoablation with hot water vapour based on a new type of microtube was developed. This approach allows tumours, with volume and anatomical positions not accessible to other techniques (cryoablation, radiofrequency ablation, laser ablation) to be treated.The method was tested on a human colon carcinoma grafted subcutaneously in Swiss nude mice and the experiment monitored under magnetic resonance imaging.It was found that 2.52 cal s(-1) per cm3 of tumour were necessary to reduce tumour size. The microtube is built to withstand a large range of temperatures and pressures and is biocompatible.A specific feature of this technique is that, besides hot vapour, several types of drugs can be delivered through the same microtube depending of the location, type or size of the tumour. These properties make it a unique device for multi-therapeutic treatments.

Cryoablation

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Citations (8)