Blanca E. Millán‐Chiu

Universidad Nacional Autónoma de México

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Achim M. Loske

Universidad Nacional Autónoma de México

Luz M. López-Marı́n

Universidad Nacional Autónoma de México

Rubén López‐Martínez

Universidad Nacional Autónoma de México

Francisco J. Fernández

Centro de Investigaciones Biológicas Margarita Salas

Luis Javier Méndez‐Tovar

Hospital de Especialidades

Patricia Manzano–Gayosso

Universidad Nacional Autónoma de México

Miguel A. Gómez‐Lim

Instituto Tecnológico Superior de Irapuato

Francisca Hernández Hernández

Universidad Nacional Autónoma de México

Maria del Pilar Rodriguez‐Torres

Universidad Nacional Autónoma de México

Laura Susana Acosta‐Torres

Universidad Nacional Autónoma de México

Cooperative Institutions

Universidad Nacional Autónoma de México

Autonomous University of Queretaro

Instituto Politécnico Nacional

Tecnologie Avanzate (Italy)

Center for Research and Advanced Studies of the National Polytechnic Institute

Centro de Investigaciones en Optica

Consejo Nacional de Humanidades, Ciencias y Tecnologías

Instituto Mexicano de Oftalmología IAP

Instituto Tecnológico de Querétaro

Tecnológico Nacional de México

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Resistencia a compuestos azólicos de aislamientos clínicos de Trichophyton spp

Revista Iberoamericana de Micología (2007)

Luis Javier Méndez‐Tovar Patricia Manzano–Gayosso Verónica Velásquez-Hernández Blanca E. Millán‐Chiu Francisca Hernández Hernández

Trichophyton tonsurans

10.1016/s1130-1406(07)70065-7

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Citations (24)

Effect of Shock Waves on the Growth of Aspergillus niger Conidia: Evaluation of Germination and Preliminary Study on Gene Expression

Journal of Fungi (2022)

Daniel Larrañaga Ordaz Miguel Ángel Martínez-Maldonado Blanca E. Millán‐Chiu Francisco J. Fernández Eduardo Castaño‐Tostado

Shock waves, as used in medicine, can induce cell permeabilization, genetically transforming filamentous fungi; however, little is known on the interaction of shock waves with the cell wall. Because of this, the selection of parameters has been empirical. We studied the influence of shock waves on the germination of Aspergillus niger, to understand their effect on the modulation of four genes related to the growth of conidia. Parameters were varied in the range reported in protocols for genetic transformation. Vials containing conidia in suspension were exposed to either 50, 100 or 200 single-pulse or tandem shock waves, with different peak pressures (approximately 42, 66 and 83 MPa). In the tandem mode, three delays were tested. To equalize the total energy, the number of tandem “events” was halved compared to the number of single-pulse shock waves. Our results demonstrate that shock waves do not generate severe cellular effects on the viability and germination of A. niger conidia. Nevertheless, increase in the aggressiveness of the treatment induced a modification in four tested genes. Scanning electron microscopy revealed significant changes to the cell wall of the conidia. Under optimized conditions, shock waves could be used for several biotechnological applications, surpassing conventional techniques.

Aspergillus niger

10.3390/jof8111117

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Citations (2)

Graphene oxide and reduced graphene oxide modification with polypeptide chains from chicken feather keratin

Journal of Alloys and Compounds (2014)

Edgar Jiménez-Cervantes Amieva Rosalba Fuentes‐Ramírez Ana Laura Martínez‐Hernández Blanca E. Millán‐Chiu Luz M. López-Marı́n

Biocompatibility

Biomolecule

Surface Modification

10.1016/j.jallcom.2014.12.062

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Citations (32)

Shock Wave Application Increases the Antineoplastic Effect of Molecular Iodine Supplement in Breast Cancer Xenografts

Ultrasound in Medicine & Biology (2019)

Mirle Peña Evangelina Delgado-González Luz M. López-Marı́n Blanca E. Millán‐Chiu F. Fernández

10.1016/j.ultrasmedbio.2019.11.015

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Citations (7)

Dynamic light scattering: A fast and reliable method to analyze bacterial growth during the lag phase

Journal of Microbiological Methods (2017)

S. Vargas Blanca E. Millán‐Chiu Sofía M. Arvizu‐Medrano Achim M. Loske R. Rodrı́guez

Bacterial growth

Lag time

Intensity

Generation time

Light intensity

10.1016/j.mimet.2017.04.004

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Citations (24)

Biocompatibility of liposomes derived from microbial cells: an assesment towards Nanomedicine applications

Carlos M. Valdemar-Aguilar R. Nava Angel O. Tinoco-Martinez V.D. Compeán-García Blanca E. Millán‐Chiu

The emergence of Nanotechnology in Medicine has resulted in the development of a wide set of nanocarriers. One of the most popular approaches in drug delivery is the use of liposomes, which are self-assembled lipid bilayers. Mammalian-derived liposomes are known to be highly biocompatible. However, the toxicity of liposomes prepared with microbial lipids is still to be clarified. Strains from the genus Mycobacterium are able to induce a high immune response in humans, which is known to involve the responses towards the amphipathic lipids they synthesize, and various reports have proposed the use of mycobacterial liposomes as adjuvants and vaccine boosts. In this work, M. fortuitum and M. tuberculosis lipids were used to produce mycobacterial-derived liposomes, and their physical and chemical characterization, as well as biocompatibility vis-a-vis human cells are addressed.

Biocompatibility

Nanocarriers

10.1109/coniin.2016.7498126

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Underwater Shock Wave-Enhanced Cavitation to Induce Morphological Changes and Cell Permeabilization in Microscopic Fungi

Fluids (2024)

Miguel Ángel Martínez-Maldonado Blanca E. Millán‐Chiu Francisco J. Fernández Daniel Larrañaga Ordaz Miguel A. Gómez‐Lim

Since the discovery of extracorporeal lithotripsy, there has been an increased interest in studying shock wave-induced cavitation, both to improve this technique and to explore novel biotechnological applications. As shock waves propagate through fluids, pre-existing microbubbles undergo expansion and collapse, emitting high-speed microjets. These microjets play a crucial role in the pulverization of urinary stones during lithotripsy and have been utilized in the delivery of drugs and genetic materials into cells. Their intensity can be amplified using tandem shock waves, generated so that the second wave reaches the bubbles, expanded by the first wave, during their collapse. Nevertheless, there is little information regarding the control of microjet emissions. This study aimed to demonstrate that specific effects can be obtained by tuning the delay between the first and second shock waves. Suspensions containing Aspergillus niger, a microscopic fungus that produces metabolites with high commercial value, were exposed to single-pulse and tandem shock waves. Morphological changes were analyzed by scanning and transmission electron microscopy. Proteins released into the medium after shock wave exposure were also studied. Our findings suggest that, with enhanced control over cavitation, the detachment of proteins using conventional methods could be significantly optimized in future studies.

10.3390/fluids9040081

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Citations (2)

Extracción de quitina de Aspergillus niger asistida por ondas de choque: caracterización fisicoquímica y eléctrica

Mundo Nano Revista Interdisciplinaria en Nanociencia y Nanotecnología (2023)

Blanca E. Millán‐Chiu Eduardo Abel Alarcón Flores Eduardo Ortiz-Olan Francisco Fernández Achim M. Loske

La quitina es un polisacárido lineal producido por especies animales y fúngicas. Una de sus principales fuentes de obtención es el hongo Aspergillus niger, cultivado en biorreactores industriales. Es un biopolímero neutro que modifica las propiedades eléctricas de los materiales compuestos, una característica muy útil para algunos dispositivos electrónicos. Nuestro objetivo en este trabajo fue la caracterización fisicoquímica de películas de quitina, extraída de dicho hongo por un método químico asistido por ondas de choque y calor, así como también determinar su resistividad eléctrica al aplicarle altos voltajes (entre 10 y 20 kV). Las ondas de choque se utilizaron en este estudio porque se sabe que inducen poros en las células y podrían promover la entrada de álcali en la hifa, permitiendo una mejor eliminación de los componentes celulares residuales. La quitina fue neutralizada, secada y se formaron películas. Los valores de proteína residual se cuantificaron con la técnica de ácido bicinconínico (BCA), obteniendo películas con bajas cantidades de proteína. La caracterización del morfotipo específico extraído se estimó mediante infrarrojo transformado de Fourier (FTIR) y difracción de rayos X (XRD). Para evaluar la resistividad ante voltajes elevados, se diseñó un circuito especial que permitió detectar variaciones significativas de esta con respecto al voltaje aplicado, es decir, la quitina mostró un comportamiento coincidente con un varistor no lineal y, hasta donde sabemos, este es el primer informe de dicho comportamiento para la quitina.

10.22201/ceiich.24485691e.2023.31.69796

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Citations (1)

Nanotoxicology in Plants

Nanotechnology in the life sciences (2020)

Blanca E. Millán‐Chiu Maria del Pilar Rodriguez‐Torres Achim M. Loske

Nanotoxicology

10.1007/978-3-030-39246-8_3

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Citations (16)

Thermally Stable All-Natural Agar Eutectogels for Transient Iontronics

ACS Applied Polymer Materials (2025)

Saúl Carrasco‐Saavedra Maricarmen Vilchis-Cuevas Griselda Blanco-Gutiérrez Nicolas R. Tanguy Gerardo A. Fonseca-Hernández

Iontronics has propelled the development of innovative devices that can be made transient and possess distinct functionalities as compared to traditional electronics. The combination of deep eutectic solvents (DESs), and eutectic solvents more broadly, and biopolymers has enabled the preparation of eutectogels, a group of ionically conducting materials capable of operating over a wider window of temperatures than hydrogels. However, eutectogels based on biopolymers generally exhibit limited thermal stability at high temperatures, which has limited their applicability in iontronics. In this study, the development of thermally stable eutectogels (melting point above 79 °C and degradation at ∼110 °C) is demonstrated by combining agar with hydrated eutectic solvents and sorbitol. Additionally, the all-natural agar-based eutectogel demonstrated high ionic conductivity (1.1–3.4 mS cm–1), tensile strength (140 kPa), and compression strength (500–600 kPa). Furthermore, the presence of choline chloride in the eutectic solvents imparts the eutectogels with notable antifungal activity against C. albicans, A. niger, and Corynespora sp. Leveraging these properties, the eutectogels were tested as transient strain sensors, broadening their application to next-generation wearable and soft robotics devices capable of resisting microbial colonization.

Transient (computer programming)

10.1021/acsapm.4c03172

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