Jorge Luiz Costa Castro

Pontifícia Universidade Católica do Paraná

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Andrígo Barboza De Nardi

Universidade Estadual Paulista (Unesp)

Rafael Ricardo Huppes

Medico

Josiane Morais Pazzini

Centro Universitário Católico Salesiano Auxilium

Alceu Gaspar Raiser

Universidade Federal de Santa Maria

Verônica Souza Paiva Castro

Universidade Federal de Santa Maria

Sérgio Santalucia

Universidade do Sul de Santa Catarina

Vinícius Gonzalez Peres Albernaz

Universidade Estadual Paulista (Unesp)

Ariele Aparecida Ferreira

Universidade Federal do Paraná

Ana Lúcia Pascoli

Universidade Estadual Paulista (Unesp)

Jair Rodini Engrácia Filho

Pontifícia Universidade Católica do Paraná

Cooperative Institutions

Universidade Federal de Santa Maria

148

Universidade Estadual Paulista (Unesp)

146

Universidade Federal do Rio Grande do Sul

107

Núcleo de Pesquisas Aplicadas (Brazil)

103

Universidade de Franca

Pontifícia Universidade Católica do Paraná

Universidade de São Paulo

Universidade Federal do Paraná

Associação Brasileira de Oncologia Veterinária

Universidade Federal de Minas Gerais

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Marsupialização da vesícula urinária em um cão

MEDVEP. Revista Científica de Medicina Veterinária. Pequenos Animais e Animais de Estimação (2012)

Paulo de Tarso de Oliveira Leme Débora Maria Marques Callado de Oliveira Jorge Luiz Costa Castro Alceu Gaspar Raiser Andrea Henriques

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Hipoplasia medular segmentar múltipla em um felino doméstico

ACTA SCIENTIAE VETERINARIAE (2014)

Vinícius Gonzalez Peres Albernaz Andressa Thais Roncoski Gustavo Dittrich Liv Cristina Miara Jorge Luiz Costa Castro

Background: The nervous system is one of the most affected by congenital malformations. These can occur during neural tube formation or failed neurogenesis. Segmental spinal cord hypoplasia commonly involves two or three spinal segments in the thoracolumbar region. It is characterized by incomplete formation of the spinal cord and may also be followed by spine column malformations. Clinical signs usually include functional impairment of the hindlimbs. Diagnosis is based on history, clinical signs, age, radiographs and is confi rmed with necropsy and histopathological fi ndings. There is no treatment for this condition and the animals present low life quality. This paper aims to report the clinical, radiographic and histopathological aspects of multiple segmental spinal cord hypoplasia in a domestic cat. Case: A 52-days-old, female, Persian breed, domestic cat weighing 0.55 kg was treated presenting a history of pelvic limb paraplegia associated with urinary and fecal incontinence since birth. On clinical examination there were fl accid paraplegia of hind limbs associated with absence of proprioception, anal refl ex and tone and postural defi cits. Also, all spinal refl exes of pelvic limbs and deep and superfi cial pain were absent. There was no clinical history of muscular tremors, nystagmus, seizures or other central nervous system signs. The other animals of the litter showed no apparent changes. Radiographic examination of the thoracolumbar and lumbosacral region showed enlargement of the spinal cord canal extending from the caudal portion of L1 to L7 and flattening of the dorsal and ventral blades. It was observed that the height of the L5 spinal canal, the larger dilatation site, was about 300% higher than the cranial portion of L1, considered the last normal segment. Due to low life quality, the animal was euthanized and samples were collected. Histopathological examination showed neuronal loss in the gray matter, thickening of the dura mater and loss of definition of gray and white matter, confirming the diagnosis of spinal segmental hypoplasia in multiple regions of the spinal cord. Discussion: Based on the clinical signs reported, the cat had lower motor neuron lesion, with absence of nerve conduction on femoral, sciatic, pudendal and pelvic nerves, associated with absence of afferent sensory nerve fi bers to the brain. The medullary measurement model proposed in this paper may be useful in quantifying, with no need of advanced imaging, the enlargement of the spinal canal, which is currently an empirical and subjective evaluation. The prognosis for the animal is reserved, considering that there is no specifi c treatment for the correction of spinal changes. Few reports show follow-up after diagnosis and in most cases euthanasia is indicated due to the weakness of the animal and low life quality. Intestinal and urinary infections are common, besides the appearance of scars because of paraplegic members dragging. The disease is rarely reported in the veterinary medical literature in pets and many features remain unknown. In this case, the data obtained during the history and physical examination corroborated significantly in suspicious for congenital thoracolumbar and lumbosacral spinal cord disease. The radiographic sign of dilatation of the lumbar spinal canal in multiple vertebrae is strongly suggestive of multiple congenital abnormalities. Due to low quality of life and prognosis, the animal was euthanized, allowing the post-mortem diagnosis of multiple segmental spinal cord hypoplasia.

Neurological examination

Paraplegia

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Inflammatory Mammary Carcinoma in a Male Dog—Case Report

Topics in companion animal medicine (2019)

Daniella Matos da Silva Lucas Kluthcovsky Hannelore Jensen de Morais Gabrielle Moro Pallú Guilherme Cleverson Dos Santos

Histopathology

Mammary tumor

Mammary carcinoma

Metastatic carcinoma

10.1016/j.tcam.2019.100357

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Liposarcoma with perineal hernia in dog

Revista Brasileira de Ciência Veterinária (2014)

Jorge Luiz Costa Castro Sérgio Santalucia Verônica Souza Paiva Castro Marcos Vinícius Mota Pires Sara Maria de Carvalho e Suzano

Liposarcoma is an uncommon malignant tumor originated in the lipoblasts that usually does not produce metastases, but is locally invasive.The final diagnosis is made by histopathology and wide surgical excision is the treatment.A four years old male Pinscher, weighing 2.8 kg, which was previously submitted to seven therapeutic procedures for hepatoid adenoma, was brought to us.On clinical examination a large, soft consistency and painless tumor on lumbodorsal area, besides perineal hernia, was observed.The CT scan revealed an image of an extensive paravertebral intramuscular tumor, embracing retroperitoneal, pelvic canal and ad-anal region.After surgical resection, the material was sent for histopathological examination which confirmed it was a liposarcoma.Thus, chemotherapy protocol with doxorubicin was established.12 months after the last application of chemotherapy, the patient shows no signs of tumor recurrence nor metastases.

10.4322/rbcv.2014.378

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Eversão bilateral de terceira pálpebra em cão Relato de caso

MEDVEP. Revista Científica de Medicina Veterinária. Pequenos Animais e Animais de Estimação (2011)

Rogério Luizari Guedes Thiago de Oliveira Cunha Ialo Ferro de Castro Caroline Simeoni Posser Marcella Teixeira Linhares

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Mandibulectomia total, um desafio cirúrgico!

DELOS Desarrollo Local Sostenible (2024)

Rafael Ricardo Huppes Ana Lúcia Pascoli Luciana Zanfelicio Degasperi Giovanna Carolina Rothert de Oliveira Josiane Morais Pazzini

Mandibulectomia consiste na ressecção de seções variadas da mandíbula, varia de acordo com a localização e extensão do comprometimento ósseo, podendo ser unilateral rostral, central, caudal, uni ou bilateral. São comumente indicadas para neoplasias e doenças periodontais graves, entretanto as mandibulectomias totais tem sido pouco relatada devido a insegurança quanto a adaptação ao se alimentar, estética e qualidade de vida do paciente. Este estudo relatou o uso da técnica em quatro pacientes, sendo dois acometidos por neoplasias, um por doença periodontal grave e outro por fratura e osteomielite grave. Os pacientes não tiveram complicações pós-operatórias. Os dois pacientes acometidos por neoplasias tiveram sobrevida de 10 meses, e os outros estão bem atualmente, com sobrevida de mais de dois anos, demonstrando que o uso da técnica para esses pacientes trouxe qualidade de vida e maior sobrevida.

10.55905/rdelosv17.n60-007

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Trepanação para ressecção de hemangiossarcoma na cavidade nasal de cão: relato de caso

Nosso Clínico (2019)

Maressa R Sartori Ivna S Ruiz Rafael R. Huppes Marla Tereza Frasson Rafael Conceição de Souza

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Plasma rico em plaquetas (PRP) na reparação osteo-articularem pequenos animais Revisão

MEDVEP. Revista Científica de Medicina Veterinária. Pequenos Animais e Animais de Estimação (2012)

Débora Maria Marques Callado de Oliveira Paulo de Tarso de Oliveira Leme Jorge Luiz Costa Castro João Eduardo Wallau Schossler

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Thoracic and Abdominal Wall Reconstruction with Polypropylene Mesh after High Grade Infiltrative Fibrosarcoma Resection in a Dog

ACTA SCIENTIAE VETERINARIAE (2015)

Jorge Luiz Costa Castro Vinicius Gonzales Peres Albernaz Ariele Aparecida Ferreira Clara Biange dos Santos Moratelli Gustavo Dittrich

Background: Soft tissue sarcomas are a group of invasive malignant tumors formed by neoplastic mesenchymal cells. In most cases, the treatment require surgical resection. When sarcoma characteristics disqualify conventional tumor excision, polypropylene mesh can be used for abdominal or chest wall reconstruction. This paper aims to describe the clinical, computed tomography features, histopathlogical and immunohistochemical aspects of a chest wall fibrosarcoma, as well as to describe the tumor excision technique combined with resection of multiple ribs, diaphragm advancement and reconstruction of thoracic and abdominal wall with a synthetic polypropylene mesh. Case: An 11-year-old male Boxer was presented with a progressive growth tumor in the left paralumbar area. The invasive tumor measuring 15 cm in diameter, was firm epidermodermal coverage and was adherent to the subcutaneous tissue, having a smooth and non-ulcerative skin surface. Ultrasound of the mass consisted of a heterogeneous structure comprising paralumbar region, invading abdomen and left thoracic wall. Thoracic radiography showed no signs of nodular interstitial pulmonary pattern compatible with metastasis. The dog was submitted to a CT examination of thoracolumbar region, which demonstrated the presence of the circumscribed mass, measuring approximately 17 cm in diameter in the left paralumbar region with involvement of both paraspinal and transversus abdominis muscles in the region of T13 to L4 with a periosteal reaction of the left 13 th rib. Cytopathology demonstrated fusiform cells with evident nucleoli, moderate anisocytosis, anisocariose, pleomorphism and mitotic activity. Histopathological analysis revealed infiltrative neoplastic proliferation of elongated oval tumor cells with large nucleus and abundant eosinophilic cytoplasm, confirming undifferentiated sarcoma. Further, the sample was sent for immunohistochemical analysis, which was suggestive of high-grade fibrosarcoma. The patient was referred for paralumbar neoplasia resection and plastic-reconstructive surgery. While in lateral recumbency, the animal was submitted to a circular incision around the tumor. During tumor dissection, it was noted the involvement of 11 th , 12 th and 13 th ribs, lateral abdominal musculature, as well as the pleura, peritoneum and adjacent soft tissues, so, these structures had to be removed. After tumor removal, a 20 cm diameter thoracic and abdominal defect had to be corrected by the advancement and reintegration of diaphragmatic crus in the caudal border of the 10 th rib. Closure of the abdominal wall was performed by surgical implantation of a double layer polypropylene mesh, which was fixed by sutures in the adjacent musculature. Cutaneous closure was possible by performing four tension relief incisions parallel the incision line. During postoperative period, the animal developed hypotension and severe blood loss and anemia. Six h after the surgery, the animal presented cardiopulmonary arrest unresponsive to resuscitation protocol. Discussion: Fibrosarcoma has biological characteristics of high malignancy, low metastasis rates and high invasiveness. The objective of fibrosarcoma treatment is the complete surgical excision of the tumor. En bloc excision is the main chest wall tumor treatment and includes resection of ribs, muscles, pleura and adjacent tissue to obtain clean surgical margins. In this case, primary closure of chest and abdominal wall was not possible due to extension of defect after tumor removal. The use of polypropylene mesh proved to be fundamental to lateral thoracoabdominal muscle layer closure. According to laboratory tests and the presence of hemorrhage and anemia during postoperative period, the authors believe that the patient developed disseminated intravascular coagulation, which significantly contributed to patient’s death.

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Idiopathic Diﬀuse Lipomatosis in Dogs

ACTA SCIENTIAE VETERINARIAE (2016)

G. V. Sechi Carolina Cavalcante Carolina Cavalcante Marconi Rodrigues de Farias Marconi Rodrigues de Farias

Background: Idiopathic diffuse lipomatosis is a rare disease in veterinary medicine. It is characterized by excessive proliferation of adipocytes, which results in the formation of fatty tumours throughout the body. In humans, this disease is also known as Madelung’s disease or multiple symmetric lipomatosis and is classifed as type I and II. The aim of this study was to investigate two cases of dogs diagnosed with idiopathic diffuse lipomatosis and compare their characteristics with those found in humans.Cases: Case 1 - A 3-year-old standard poodle female was taken for veterinary evaluation for a slow-growing tumoural lesion over the neck and trunk. The tumours measured >30 cm in diameter that caused irregular and protruding folds resulting in a signifcant loss of body architecture. No clinical signs of adjacent systemic disease were observed. Elliptical excisions of the skin revealed diffuse mature adipocytes and hyperplastic and dysplastic lipoblast hypertrophy of the panniculus, which was associated with epidermodermal hypotrophy and skin appendages. The combination of these fndings supported a diagnosis of idiopathic diffuse lipomatosis. The animal underwent surgical therapy. However, the clinical symptoms recurred within two months. Owing to the continuous recurrence of tumours and history of three other surgeries, it was decided to euthanize the animal. Case 2 - An 11-year-old female cocker spaniel preenting tumoural lesions of insidious evolution and widespread distribution. Clinical examination revealed the presence of multiple subcutaneous tumours in the lateral, lumbosacral, and abdominal regions of the pelvic limb. No clinical signs of adjacent systemic disease were observed. Biopsies of tumoural lesions also supported the diagnosis of idiopathic diffuse lipomatosis. The animal was fed a low-calorie diet, after which its body weight decreased without inducing any changes in tumour size. In addition, the animal underwent surgical treatment for removal of the largest tumours. After surgery, the animal was monitored for 1year and showed no tumour recurrence.Discussion: In veterinary medicine, lipomatosis is an extremely rare disease. Therefore, before diagnosing a case, it is necessary to exclude other proliferative disorders of the adipose tissue, among which, the most common are lipomas and liposarcomas. There are no genetic studies related to lipolytic activity or adipocyte proliferation in animals. However, it is believed that the aetiology of idiopathic diffuse lipomatosis is similar to the pathophysiology of the human form of multiple symmetrical lipomatosis, and could be associated with a primary lipid metabolism disorder. In this study, the two cases described showed a distinct distribution in the type of tumours. In case 1, the tumours were well defned and focused in the cervical and thoracic region, a pattern similar to human type I lipomatosis. However, in case 2, the fat accumulationswere diffuse and mainly located in the posterior region of the animal’s body similar to type II lipomatosis. No animals presented intra-abdominal or intrathoracic fat infltration, diagnosed by ultrasound or radiography. There is no description of any treatment capable of being effective. However, surgical procedures are recommended to minimize the occurrence of tumours and improve the quality of life of the affected animals. In the two cases described in this study, it was diffcult to completely resect the tumours. In the frst case, the recurrence of fatty deposits and performance of multiple interventions resulted in a poor quality of life of the animal, which was fnally euthanized to avoid further suffering. Therefore, frequentrecurrences might correlate with a poor prognosis in dogs.Keywords: fat, subcutaneous, tumour, skin.

Lipomatosis

Lumbosacral joint

10.22456/1679-9216.84750

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