Research Articles| October 28 2008 Veränderungen der Dynamik des linken Ventrikels des Hundes unter paariger Stimulation vor und nach β-Blockade Subject Area: Cardiovascular System R. Köhler; R. Köhler Aus der Kardiovaskulären Abteilung (Leitung: Prof. E. Lüthy) der Medizinischen Universitäts-Poliklinik (Direktor: Prof. R. Hegglin) und der Chirurgischen Universitäts-Klinik A (Direktor: Prof. A. Senning) des Kantonsspitals Zürich Search for other works by this author on: This Site PubMed Google Scholar W. Rutishauser; W. Rutishauser Aus der Kardiovaskulären Abteilung (Leitung: Prof. E. Lüthy) der Medizinischen Universitäts-Poliklinik (Direktor: Prof. R. Hegglin) und der Chirurgischen Universitäts-Klinik A (Direktor: Prof. A. Senning) des Kantonsspitals Zürich Search for other works by this author on: This Site PubMed Google Scholar M. Gander; M. Gander Aus der Kardiovaskulären Abteilung (Leitung: Prof. E. Lüthy) der Medizinischen Universitäts-Poliklinik (Direktor: Prof. R. Hegglin) und der Chirurgischen Universitäts-Klinik A (Direktor: Prof. A. Senning) des Kantonsspitals Zürich Search for other works by this author on: This Site PubMed Google Scholar I. Babotai I. Babotai Aus der Kardiovaskulären Abteilung (Leitung: Prof. E. Lüthy) der Medizinischen Universitäts-Poliklinik (Direktor: Prof. R. Hegglin) und der Chirurgischen Universitäts-Klinik A (Direktor: Prof. A. Senning) des Kantonsspitals Zürich Search for other works by this author on: This Site PubMed Google Scholar Cardiologia (1966) 49 (3): 135–138. https://doi.org/10.1159/000168924 Article history Published Online: October 28 2008 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation R. Köhler, W. Rutishauser, M. Gander, I. Babotai; Veränderungen der Dynamik des linken Ventrikels des Hundes unter paariger Stimulation vor und nach β-Blockade. Cardiologia 1 March 1966; 49 (3): 135–138. https://doi.org/10.1159/000168924 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsCardiologia Search Advanced Search This content is only available via PDF. 1966Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Article PDF first page preview Close Modal You do not currently have access to this content.
We have developed a new method of measuring absolute coronary blood flow (CBF) in all major branches of the coronary circulation using computer analysis of conventional cineangiograms. A coronary cineangiogram is obtained in any biplane projections at 50 fps and digitized into a 512 x 512 x 8 matrix. The artery is reconstructed in 3D using the x-ray projection matrices calculated from a cube filmed in the same projections. All diameters along the artery are automatically determined. The arterial volume is calculated from the 3D reconstructed true arterial length and diameters. The absolute flow is obtained by dividing the arterial volume filled by contrast medium during the first cardiac cycle following the injection by the duration of that cycle. The method was validated in vivo by comparing LAD flow measured by angiography with great cardiac vein flow simultaneously measured by thermodilution. Ten patients were studied at baseline and during pacing-induced hyperemia at 100 and 120/min. Mean flow was 52.1 ml/min (range 28-93) by angiography and 51.5 ml/min (range 11-115; NS) by thermodilution. The two methods correlated well: r = 0.82, SE = 9.8 ml/min, n = 27, p less than 0.0001. Thus, absolute CBF can be measured by computer analysis of conventional biplane coronary cineangiograms.
To assess the potential of coronary collateral circulation to protect myocardium after occlusion of a coronary vessel, the mean coronary wedge pressure, the angiographic grade of collateral channels, and the left ventricular function were studied in 47 consecutive patients with mechanical recanalization of totally occluded coronary arteries. Coronary wedge pressure measurements were obtained 39 +/- 51 days (range, 2 hours to 361 days) after the presumed time of occlusion. The patients were divided into two groups: 31 with a coronary wedge pressure more than 30 mm Hg (group 1) and 16 with a coronary wedge pressure of or less than 30 mm Hg (group 2). Patients in group 1 had a significantly higher mean global left ventricular ejection fraction than those in group 2 (63 +/- 9% vs. 49 +/- 7%, p less than 0.001). Regional left ventricular function (artery-related area change) was also superior in group 1 compared with group 2 (47 +/- 11% vs. 36 +/- 10%, p less than 0.01). Global left ventricular function was significantly correlated to coronary wedge pressure (r = 0.51, p less than 0.001) but not to the angiographic presence of collaterals. The data suggest that a high coronary wedge pressure is associated with improved left ventricular function after coronary artery occlusion and that coronary wedge pressure more accurately reflects the physiological role of collaterals than their angiographic presence.
Since the duration of precordial pain plays a key role in the indication for thrombolytic treatment in acute myocardial infarction, a retrospective study was made of the last 200 infarctions at Monthey Hospital with particular reference to the factors influencing this duration (distance, type of transport, prior intervention by a physician, loss of time in hospital). These factors were compared with other studies, and ways of influencing the time factor are proposed.
Ninety-three consecutive patients with chronic total coronary occlusion underwent an attempted mechanical des-obliteration by percutaneous coronary angioplasty with a balloon catheter. The global results were 55 p. 100 initial successes (residual stenosis less than 50 p. 100). The good prognostic factors were: 1) left coronary artery, especially left circumflex artery occlusion p less than 0.50, and 2) the proximity to the date of occlusion as assessed from the clinical history or by the occurrence of occlusion between the time of diagnostic coronary angiography and angioplasty. In cases of recent occlusion dating less than one month, the success rate was high: 69 p. 100. On the other hand, there were no successes in occlusions of over 6 months standing. The presence of myocardial infarction did not influence the results. There were few complications (7 p. 100) and these did not include any deaths or cases requiring emergency surgery. Exercise stress tests were carried out after the procedure and were negative in 28 out of 32 patients (88 p. 100). Forty-three patients successfully revascularised were followed up for 1 to 48 months (average 9 months) after angioplasty. Thirty-one patients were asymptomatic. Of the 12 symptomatic patients, 7 underwent exercise stress tests (6 positive) and all had control angiography which showed restenosis in 10 cases with 5 occlusions. Percutaneous coronary angioplasty of recent total coronary occlusions gives good initial results without major complications, and the medium term clinical results are satisfactory.
