W Rutishauser

Valens Clinics

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P Wirz

University Hospital of Bern

Krayenbühl Hp

University Hospital of Zurich

M Schönbeck

University of Zurich

Léo Finci

University Hospital of Geneva

A Righetti

University Hospital of Geneva

Bernhard Meier

ETH Zurich

F Mahler

Max-Born-Institute for Nonlinear Optics and Short Pulse Spectroscopy

P Chatelain

University Hospital of Geneva

Osman Ratib

University Hospital of Geneva

G Noseda

University of Zurich

Cooperative Institutions

University Hospital of Geneva

University of Zurich

University Hospital of Bern

University of Bern

University of Lausanne

University Hospital of Zurich

Valens Clinics

Hôpital Beau-Séjour

University of Geneva

Klinik und Poliklinik für Neurologie

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Effect of gravitational and inertial forces on pleural and esophageal pressures

Journal of Applied Physiology (1967)

W Rutishauser Natalio Banchero A. G. Tsakiris Earl H. Wood

Supine position

Sitting

Respiratory physiology

10.1152/jappl.1967.22.6.1041

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Citations (28)

[Physiopathology of "constant" splitting of the second heart sound in atrial septal defect during respiration].

PubMed (1969)

A Chukwuemeka W Rutishauser

Pathophysiology

Constant (computer programming)

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Effets d'un dérivé nitré retard au repos et au cours d'épreuves cyclo-ergométriques chez le coronarien.

Annales de Cardiologie et d Angéiologie (1979)

J M Boutefeu Andrea Righetti W Rutishauser

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Effects of dialysate composition during hemodialysis on left ventricular function.

PubMed (1993)

Juan Sztajzel Patrick Ruedin Catherine Stoermann C Monin Jürg A. Schifferli

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Citations (9)

[Effect of coronary flow reduction on the coronary flow distribution, the myocardial metabolism and left ventricular hemodynamics].

PubMed (1976)

B Villiger R Lerch Riedhammer Hh Meier We Renk Iw

Myocardial blood flow, left ventricular performance, regional myocardial metabolites (ATP, CrP, lactate) and a-v differences of oxygen, lactate and pyruvate were determined in 6 open chest dogs with cannulated left coronary artery. A mean flow reduction from 92 to 43 ml/min/100 g heart weight resulted in marked heart failure accompanied by extensive flow reduction to the endocard with nearly 10 fold increase of lactate and a decrease of CrP content to 50% of control. In contrast, flow and metabolic parameters of the epicardial part changed only slightly. Furthermore, the DPTI/SPTI-ratio showed a good correlation with the subendocardial CrP content (r = 0.93, p less than 0.01).

Left coronary artery

Coronary circulation

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Effects of Bopindolol on Left Ventricular Function During Exercise in Patients with Coronary Artery Disease

Journal of Cardiovascular Pharmacology (1986)

A Righetti G Mérier Christian E. Viquerat Osman Ratib W Rutishauser

Bopindolol is a new beta blocker with a long duration of action. We examined the haemodynamic effects of multiple oral doses of 2 mg in 12 male patients, with coronary artery disease. Placebo was given for 7 days followed by bopindolol 2 mg daily for 14 days. Scintigraphic ventriculography combined with an exercise test was carried out at baseline before treatment with bopindolol, and repeated after 7 and 14 days treatment. On day 7 the measurements were made 2 h after therapy (i.e., when plasma levels were maximal) and on day 14 when plasma levels were lowest (24 h after the last dose). The results showed that bopindolol had little effect on blood pressure or heart rate at rest in these normotensive patients but that both parameters measured after exercise were statistically significantly reduced (p less than 0.001). There was little difference between the effect seen 2 h after therapy and the effect seen 24 h after therapy, thus, demonstrating the long duration of action. The mean ejection fraction was not changed by bopindolol either at rest or after exercise but individual patients who responded to exercise with a fall in ejection fraction before treatment did not do so following treatment. These were mainly patients with 2 and 3 artery disease and the failure of the mean ejection fraction to show this protective effect was probably due to the predominance in our patients of those with mild single vessel disease who did not react adversely to exercise. We conclude that bopindolol protects the myocardium against ischaemia and that the effect lasts for at least 24 h when therapy is given once daily.

Physical exercise

10.1097/00005344-198608006-00009

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Citations (2)

[Hyper- trophy and hyperplasia of the heart. 6th International Cardiologic Symposium on 5-6 April 1968 in Titisee-Schwarzwald].

PubMed (1968)

W. Kübler Krayenbühl Hp W Rutishauser J Scholtholt

Trophy

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ON PULMONARY VALVE INSUFFICIENCY