Réka Tóth

Luxembourg Institute of Health

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Cornelia M. Ulrich

Huntsman Cancer Institute

Christoph Plass

German Cancer Research Center

Dominique Scherer

University of Washington

Pavlo Lutsik

KU Leuven

Yesilda Balavarca

German Cancer Research Center

Yassen Assenov

Epigenomics (Germany)

Shuji Ogino

Brigham and Women's Hospital

Vı́ctor Moreno

Institut Català d'Oncologia

Rosalind A. Eeles

Institute of Cancer Research

Jean–Pierre J. Issa

Coriell Institute For Medical Research

Cooperative Institutions

Heidelberg University

208

German Cancer Research Center

176

University Hospital Heidelberg

National Center for Tumor Diseases

Epigenomics (Germany)

Deutschen Konsortium für Translationale Krebsforschung

University of Debrecen

DKFZ-ZMBH Alliance

Luxembourg Institute of Health

Fred Hutch Cancer Center

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AllergoOncology: Biomarkers and Refined Classification for Research in the Allergy and Glioma Nexus - a Joint EAACI-EANO Position Paper

Authorea (Authorea) (2023)

Aurélie Poli Michelle C. Turner Urszula Radzikowska Denisa Ferastraoaru Mariona Pascal

Epidemiological studies have explored the relationship between allergic diseases and cancer risk or prognosis in AllergoOncology. Some studies suggest an inverse association, but uncertainties remain, including in IgE-mediated diseases and glioma. Allergic disease stems from a Th2-biased immune response to allergens in predisposed atopic individuals. Allergic disorders vary in phenotype, genotype, and endotype, affecting their pathophysiology. Beyond clinical manifestation and commonly used clinical markers, there is ongoing research to identify novel biomarkers for allergy diagnosis, monitoring, severity assessment, and treatment. Gliomas, the most common and diverse brain tumours, have in parallel undergone changes in classification over time, with specific molecular biomarkers defining glioma subtypes. Gliomas exhibit a complex tumour-immune interphase and distinct immune microenvironment features. Immunotherapy and targeted therapy hold promise for primary brain tumour treatment, but require more specific and effective approaches. Animal studies indicate allergic airway inflammation may delay glioma progression. This collaborative European Academy of Allergy and Clinical Immunology (EAACI) and European Association of Neuro-Oncology (EANO) Position Paper summarizes recent advances and emerging biomarkers for refined allergy and adult-type diffuse glioma classification to inform future epidemiological and clinical studies. Future research is needed to enhance our understanding of immune-glioma interactions to ultimately improve patient prognosis and survival.

10.22541/au.169956638.85807758/v1

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Supplementary Table S1 from Genetic Variants in Epigenetic Pathways and Risks of Multiple Cancers in the GAME-ON Consortium

Réka Tóth Dominique Scherer Linda E. Kelemen Angela Risch Aditi Hazra

<p>Genes selected for the study using GO and GeneCard databases and literature search to represent 10 epigenetic sub-pathways, specifically DNA methylation, DNA demethylation, histone acetylation, histone deacetylation, chromatin remodeling, histone methylation, histone demethylation, other histone modification, chromatin modification and histones.</p>

Histone Methylation

Cancer Epigenetics

DNA demethylation

Histone code

10.1158/1055-9965.22437969

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The role of selenium in nutrition and the manufacturing of selenium-enriched milk

Acta Universitatis Sapientiae Alimentaria (2022)

Réka Tóth Dorina R. Kiss J. Csapó

Abstract The role of selenium has increased after the discovery of the first seleno-enzyme in the human body. Selenium supports growth, the immune system, the reproductive organs, thyroid and muscle function, has an antioxidant effect, and protects against free radicals. The recommended daily intake of selenium for adults is 55 µg/day, which cannot be covered with food alone in selenium-deficient areas. That is the reason why we chose as our research topic the production of functional food – in this research: milk – in which the selenium level has been elevated naturally. In our work, we supplemented six Holstein-Friesian cattle feeds with a daily 1, 2, 4, and 6 mg/individual organic selenium, and then we measured the selenium content by ICP-MS. With a selenium enrichment of 1 mg/day, a 60% increase in selenium content was achieved, as the selenium content of milk increased from 32.93 µg/kg to 52.79 µg/kg. With the 2, 4, and 6 mg supplementation, the milk contained 97.2, 182.69, and 231.31 µg/kg selenium respectively. The latter is seven times more than the selenium content of the control sample. We have developed a recommendation for the amount of naturally selenized milk that should be consumed for different age groups. In our opinion, milk with increased selenium content could contribute to improving the selenium status of the population.

10.2478/ausal-2022-0007

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Insertion/deletion polymorphism of angiotensin-1 converting enzyme is associated with metabolic syndrome in Hungarian adults

Journal of the Renin-Angiotensin-Aldosterone System (2011)

Szilvia Fiatal Endre Szigethy György Széles Réka Tóth Róza Ádány

The aim of our study was to evaluate whether any association exists between metabolic syndrome (MS) and ACE I/D and AGT M235T gene polymorphisms in Hungarians as an example of European Caucasian population. Study subjects of our cross-sectional study were recruited from the Hungarian General Practitioners' Morbidity Sentinel Stations Program. The study population (n = 1762) approximates very well the age and sex distribution of the general Hungarian population. MS was defined according to the latest diagnostic criteria proposed by the International Diabetes Federation. The frequency of DD genotype (31.36% vs. 25.42%, p = 0.006) and the frequency of D allele (0.56 vs. 0.51, p = 0.006) were significantly higher in the metabolic group than in the non-metabolic group. The distribution of the AGT M235T polymorphism was similar in each group investigated. Association was shown in the case of patients in whom central obesity was combined with elevated TG and low HDL cholesterol level (p = 0.024 and p = 0.022). It suggests that ACE I/D polymorphism is likely to be involved in lipid metabolism.

10.1177/1470320310394231

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Using DEA to evaluate efficiency of higher education

Applied Studies in Agribusiness and Commerce (2009)

Réka Tóth

The aim of the higher education reform process both in Hungary and in the European countries is establishing a competitive, qualitative higher education with efficiently operating institutions. The question of efficiency needs increased attention not only because of the decline of the state support but also the rapid raise of the student mass. In the educationsystemit’snot easy to measurethe output of the services.The situation is more complicated if an organisation or a sector has multiple inputs and outputs. In this case a possible method of determining efficiency is Data Envelopment Analysis. In my paper I’d like to introduce this method and use it to compare the efficiency of higher education systems. urthermore I am examining whether their efficiency is influenced by the extent of the contribution of the state and the private sector or socio-economic factors like GDP per capita and education level of parents.

10.19041/apstract/2009/3-4/17

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Differential Urinary Proteomic Analysis of Endometrial Cancer

Physiological Research (2019)

Mária Kacírová Peter Bober Michal Alexovič Z Tomková Soňa Tkáčiková

Endometrial cancer is one of the most frequent gynecological malignancies present in more than 95 % of all uterine cancers. In spite of that, screening of such disease is not commonly performed in clinical practice due to enormous costs and relatively low sensitivity. Therefore, developing an effective screening test to diagnose endometrial cancer at early stages is of great importance for the clinical area of investigation. In this work, we applied urinary proteomics (i.e., bottom-up proteomic approach followed by nano HPLC-ESI-MS/MS) in patients with endometrial cancer, with respect to find proteins aimed for the early diagnostics and screening. According to the results, the significant semi-quantitative changes were observed in urinary proteome of treated patients. The proteins that may be pivotal in pathogenesis of endometrial cancer, like cadherin-1 (CDH1), vitronectin (VTN) and basement membrane specific-heparan sulphate proteoglycan core protein (HSPG2) were down-regulated, when compared to the control group. Ultimately, it can be stated that urinary proteomics has a potential for the searching of cancer protein biomarkers based on their altered concentration.

Proteome

CDH1

10.33549/physiolres.934375

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Differential expression of tissue transglutaminase during in vivo apoptosis of thymocytes induced via distinct signalling pathways

FEBS Letters (1997)

Zsuzsa Szondy Péter Molnár Zoltán Nemes Michael Boyiadzis Noémi Kedei

Tissue transglutaminase

Signalling

Signalling pathways

10.1016/s0014-5793(97)00140-3

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DNA Methylation Characteristics of Primary Melanomas with Distinct Biological Behaviour

PLoS ONE (2014)

Szilvia Ecsedi Héctor Hernández‐Vargas Sheila Coelho Soares-Lima Laura Vízkeleti Réka Tóth

In melanoma, the presence of promoter related hypermethylation has previously been reported, however, no methylation-based distinction has been drawn among the diverse melanoma subtypes. Here, we investigated DNA methylation changes associated with melanoma progression and links between methylation patterns and other types of somatic alterations, including the most frequent mutations and DNA copy number changes. Our results revealed that the methylome, presenting in early stage samples and associated with the BRAFV600E mutation, gradually decreased in the medium and late stages of the disease. An inverse relationship among the other predefined groups and promoter methylation was also revealed except for histologic subtype, whereas the more aggressive, nodular subtype melanomas exhibited hypermethylation as well. The Breslow thickness, which is a continuous variable, allowed for the most precise insight into how promoter methylation decreases from stage to stage. Integrating our methylation results with a high-throughput copy number alteration dataset, local correlations were detected in the MYB and EYA4 genes. With regard to the effects of DNA hypermethylation on melanoma patients' survival, correcting for clinical cofounders, only the KIT gene was associated with a lower overall survival rate. In this study, we demonstrate the strong influence of promoter localized DNA methylation changes on melanoma initiation and show how hypermethylation decreases in melanomas associated with less favourable clinical outcomes. Furthermore, we establish the methylation pattern as part of an integrated apparatus of somatic DNA alterations.

10.1371/journal.pone.0096612

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Analysis of the efficiency of higher education systems

Acta Agraria Debreceniensis (2009)

Réka Tóth

The aim of the higher education reform process both in Hungary and in the European countries is establishing a competitive, qualitative higher education. The Education Minister of our country regularly emphasizes in his statements that the quantitative changes of he past 15 years are completed, from now the emphasis must be on quality :„a degree in itself is not sufficient, the actual knowledge behind is necessary”. To achievethis aim, the government carried out several changes in the field of higher education in the past years, one of them was implementing a budget support system in accordance with the performance of the institutions. The objective of the three year long support agreement between the state and the higher education institutions is considering quality parameters and outputs beside and instead of normative (input-based) support. The other occurent and debated issue is the introduction of tuition fees. Although this plan was rejected by the national referendum on 9th March, 2008, some weeks ago an amendment bill was passed, which would mean bringing tuition fees back in the system.In my paper I am examining whether the efficiency of higher education systems are influenced by the extent of the contribution of the state and the private sector to their expenses. Furthermore I’d like to find the answer to the following question: Does it matter what principles and mechanisms play role by the distribution of the state support between the institutions of higher education.

Referendum

10.34101/actaagrar/34/2843

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Associations Between Dietary Patterns and Longitudinal Quality of Life Changes in Colorectal Cancer Patients: The ColoCare Study

Nutrition and Cancer (2017)

Biljana Gigic Heiner Boeing Réka Tóth Jürgen Böhm James E. Haber

Quality of life (QoL) is an important clinical outcome in cancer patients. We investigated associations between dietary patterns and QoL changes in colorectal cancer (CRC) patients. The study included 192 CRC patients with available EORTC QLQ-C30 data before and 12 months post-surgery and food frequency questionnaire data at 12 months post-surgery. Principal component analysis was used to identify dietary patterns. Multivariate regression models assessed associations between dietary patterns and QoL changes over time. We identified four major dietary patterns: "Western" dietary pattern characterized by high consumption of potatoes, red and processed meat, poultry, and cakes, "fruit&vegetable" pattern: high intake of vegetables, fruits, vegetable oils, and soy products, "bread&butter" pattern: high intake of bread, butter and margarine, and "high-carb" pattern: high consumption of pasta, grains, nonalcoholic beverages, sauces and condiments. Patients following a "Western" diet had lower chances to improve in physical functioning (OR = 0.45 [0.21–0.99]), constipation (OR = 0.30 [0.13–0.72]) and diarrhea (OR: 0.44 [0.20–0.98]) over time. Patients following a "fruit&vegetable" diet showed improving diarrhea scores (OR: 2.52 [1.21–5.34]. A "Western" dietary pattern after surgery is inversely associated with QoL in CRC patients, whereas a diet rich in fruits and vegetables may be beneficial for patients' QoL over time.

Red meat

Food frequency questionnaire

Refined grains

10.1080/01635581.2018.1397707

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Citations (47)