Mehmet Enes Coşkun

Gaziantep University

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H-Index

i-10 index

Research Field

Evaluation of malnutrition development risk in hospitalized children

Nutrition (2017)

Ömer Faruk Beşer Fügen Çokuğraş Tülay Erkan Tufan Kutlu Raşit Vural Yağcı

Many screening methods, such as the Screening Tool Risk on Nutritional Status and Growth (STRONGkids) and the Pediatric Yorkhill Malnutrition Score (PYMS), have been developed to detect malnutrition in pediatric patients. We aimed to explore the prevalence of malnutrition risk in hospitalized children via symptoms and identification of contributing factors, and to examine the efficacy of malnutrition screening tools for hospitalized children.STRONGkids and PYMS were applied to 1513 inpatients at 37 hospitals in 26 cities from different regions of Turkey. Physical measurements were collected at hospital admission and at discharge. z-Scores of height-for-age, weight-for-age, weight-for-height, and body mass index-for-age were calculated.Overall, 1513 patients were included in the study. A body mass index standard deviation score of less than -2 was present in 9.5% of the study population at hospital admission, whereas 11.2% of the participants had a weight-for-length/height score of less than -2 at hospital admission. According to STRONGkids results, the proportion of the patients with an underlying chronic disease was higher for the patients at high risk of malnutrition than for the patients at medium or low risk (91% compared with 47% or 45%, respectively). PYMS results indicated that patients at high risk of malnutrition have more chronic diseases (75%) than the patients at medium or low risk of malnutrition (55% and 44%, respectively).Use of anthropometric measurements in addition to screening tools to identify hospital malnutrition (such as PYMS, STRONGkids) will prevent some nutritional risk patients from being overlooked.

10.1016/j.nut.2017.10.020

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Citations (119)

Does Blood Type Have an Effect on Response to Hepatitis B Vaccine in Children? Single Center Data

Çocuk Enfeksiyon Dergisi/Journal of Pediatric Infection (2024)

Hatice Uygun Mehmet Enes Coşkun

ÖzGiriş: Hepatit B virüsü enfeksiyonu halen küresel bir sağlık sorunu olmaya devam etmektedir.Hepatit B aşısına karşı immün yanıtı birçok faktör etkileyebilir, bu bağlamda çocuklarda kan grupları ile hepatit B aşısına yanıt arasındaki olası ilişkiyi araştırmayı

Hepatitis B vaccine

Single Center

Center (category theory)

10.5578/ced.20240203

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Citations (0)

Kan Grubunun Çocuklarda Hepatit B Aşısına Yanıt Üzerinde Etkisi Var mı? Tek Merkez Verileri

Çocuk Enfeksiyon Dergisi/Journal of Pediatric Infection (2024)

Hatice Uygun Mehmet Enes Coşkun

Özgün Araştırma

10.5578/ced.20240216

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Plasma microRNA profiling of pediatric patients with immune thrombocytopenic purpura

Blood Coagulation & Fibrinolysis (2014)

Ali Bay Mehmet Enes Coşkun Serdar Öztuzcu Sercan Ergün Fatih Yılmaz

Immune thrombocytopenic purpura (ITP) is a commonly acquired autoimmune bleeding disorder in children. MicroRNAs (miRNAs) are small RNAs which are found in cells and circulation, and play a role in protein synthesis and regulation. In this study, we aimed to determine a biomarker for childhood ITP comparing the plasma miRNA levels of children having ITP with healthy children. A total of 86 patients with ITP and 56 healthy children followed up by the Department of Pediatric Hematology and Oncology in University of Gaziantep since July 2011 were enrolled in the study. The 86 patients with ITP were evaluated in two groups as 43 acute ITP (aITP) and 43 chronic ITP (cITP) patients. Plasma expression levels of 379 miRNAs were investigated by RT-PCR (quantitative RT-PCR) technique and they were compared between aITP, cITP, and control groups. For all miRNAs, the average of raw quantification cycle values of three groups separately in the analysis chip was accepted as the reference gene value, and normalization was done according to this value. Statistically significant differences were detected in seven miRNAs (miR-302c-3p, miR-483-5p, miR-410, miR-544a, miR-302a-3p, miR-223-3p, and miR-597) investigated between the groups with respect to the expression levels. The expression rates were found to be over 95% in miR-302c-3p and miR-483-5p, over 75% in miR-410, and over 40% in miR-544, miR-302a-3p, and miR-223-3p in all three groups. The detection of significant differences between plasma miRNA levels of aITP and cITP patients and healthy children may provide useful information in the prediction of the course of disease, determination of disease etiopathogenesis, and the development of new therapeutic modalities.

Thrombocytopenic purpura

Hematology

10.1097/mbc.0000000000000069

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Citations (30)

IMPORTANCE OF HYPERBILURUBINEMIA IN DIFFERENTIATION OF PRIMARY AND SECONDARY HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS IN PEDIATRIC CASES

Mediterranean Journal of Hematology and Infectious Diseases (2014)

Seval Özen Alper Dai Mehmet Enes Coşkun Serdar Öztuzcu Sercan Ergün

Background and objective: Hemophagocytic lymphohistiocytosis (HLH) is a life threatening hyper inflammatory disease. It is difficult to differentiate between primary and secondary HLH based on clinical findings at the onset of disease. We aimed to find parameters that can help to differentiate primary and secondary HLH at initial diagnosis especially for physicians working in developing countries.Patient and Method: We retrospectively analyzed data of 38 HLH patients who were admitted to the Pediatric Hematology Department of Gaziantep University between January 2009 and December 2013.Results: Of 38 patients, 20 were defined as primary and 18 were secondary HLH. The average age of primary and secondary HLH patients was 31±9 and 81±14 months, respectively (p=0.03). We found consanguinity rates significantly higher in primary HLH patients compared to secondary HLH patients (p=0.03). We found that total and direct bilirubin levels significantly increased in primary HLH patients compared to secondary HLH patients (p=0.006, p=0.044). Also, CRP levels were found markedly increased in secondary HLH patients compared to primary ones (p=0.017).Conclusion: We showed that cholestasis and hyperbilurubinemia findings of HLH patients at the initial diagnosis should be considered in favor of primary HLH and increased level of CRP should be considered in favor of secondary HLH.

Hemophagocytic Lymphohistiocytosis

Hematology

10.4084/mjhid.2014.067

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Citations (9)

Helicobacter PyloriInfection–Related Pancytopenia in a Young Boy

Pediatric Hematology and Oncology (2011)

Ali Bay Mehmet Enes Coşkun Göksel Leblebisatan Ali Seçkin Yalçın

Deficiency of vitamin B12 (VitB12), also known as cobalamin, and Helicobacter pylori infection are commonly seen in our region. Inadequate dietary intake of VitB12, lack of intrinsic factor (IF) se...

Intrinsic factor

Helicobacter

10.3109/08880018.2011.584607

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Citations (1)

Genomic damage in patients with type-2 diabetes mellitus.

PubMed (2013)

D.N. Binici Ali̇ Karaman Mehmet Enes Coşkun Oğlu Au Fatma Uçar

DNA damage seems to play a role in the pathogenesis of type-2 diabetes mellitus (DM2) and its complications. Several in vitro assays have been used to measure the DNA damage. In the present study, we aimed to investigate the frequency of sister chromatid exchange (SCE) and micronuclei (MN) in DM2 patients compared with healthy controls. SCE and MN tests were carried out with the blood-cell cultures from 50 DM2 patients and 30 healthy, age- and sex-matched control subjects. The mean age of the DM2 patients was 58.12 +/- 13.39 years, with a mean duration of the diabetes of 5.40 +/- 4.32 years. The mean level of HbAlc of the DM2 patients was 8.93 +/- 2.56. Patients with DM2 showed a higher frequency of SCE compared with controls (7.11 +/- 1.14 and 4.96 +/- 0.92, p < 0.001). Furthermore, the SCE frequency was positively correlated with the plasma HbA1c level (p < 0.05), but there was no significant correlation between the duration of diabetes and SCE. On the other hand, our result showed a MN frequency significant increase in DM2 patients (3.45 +/- 1.01 per 1000 cells) relative to that of the control group (1.79 +/- 0.67 per 1000 cells) (p < 0.001), but there was no significant correlation between the duration of diabetes, HbA1c and MN. In conclusion, these results suggest that DM2 is a condition with genomic instability characterized by an increased level of SCE and MN. Hyperglycemia-induced oxidative stress may be the underlying factor of the increased SCE and MN frequency.

Pathogenesis

Sister chromatid exchange

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Citations (31)

Plasma microRNA profiling of children with idiopathic dilated cardiomyopathy

Biomarkers (2015)

Mehmet Enes Coşkun Mehmet Kervancıoğlu Serdar Öztuzcu Fatma Yılmaz Çoşkun Sercan Ergün

Dilated cardiomyopathy (DCM) is the most common cardiomyopathy in children. MicroRNAs (miRNA) are small RNAs which have regulatory functions in many biological processes.We aimed to determine miRNA expression levels in plasma of children with DCM.Plasma expression levels of 379 miRNAs were compared between 23 DCM and 26 healthy children.The expression levels of miR-618, miR-875-3p, miR-205, miR-194, miR-302a, miR-147, and miR-544 were found decreased. The expression levels of miR-518f and miR-454 were found increased in DCM patients.miRNA level differences may provide the chance of using these miRNAs as new biomarkers.

Dilated Cardiomyopathy

10.3109/1354750x.2015.1118533

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Citations (20)

Severe Rotavirus gastroenteritis in a patient with infant leukemia

Dicle Tıp Dergisi (2011)

A. P. Bay Vuslat Boşnak Mehmet Enes Coşkun Ali Seçkin Yalçın Hatice Uygun

Rotavirus infant ve kucuk cocuklarda agir gastroenteritin en sik nedenidir. Bagisikligi baskilanmis cocuklarda rotavirus gastroenteritinin klinik seyrine ait bildiriler az sayidadir. Biz, bu raporda akut miyeloblastik losemi tanisi ile izledigimiz hayati tehdit edici rotavirus gastroenteriti gelisen bir infant olguyu sunarak, son zamanlarda tavsiye edilen Rotavirus asisina dikkat cekmek istedik.

Rotavirus gastroenteritis

Acute gastroenteritis

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Citations (2)