Sayaka Kato

Nagoya City University

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アトピー性皮膚炎の成人患者におけるアシドフィルス菌Lactobacillus acidophilus L‐92の持続性摂取の有効性

Journal of Dairy Science (2016)

Kozo Yamamoto Yokoyama Kazuhito Takehisa Matsukawa Sayaka Kato Shinji Kato

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Relationship between Physical Activity and Physical and Mental Health Status in Pregnant Women: A Prospective Cohort Study of the Japan Environment and Children’s Study

International Journal of Environmental Research and Public Health (2021)

Yasuyuki Yamada Takeshi Ebara Taro Matsuki Hirohisa Kano Hazuki Tamada

To discuss appropriate physical activity (PA) levels during pregnancy, this prospective cohort study examined the relationships between PA levels before and during pregnancy and physical and mental health status. Fixed data for 104,102 pregnant women were used from the Japan Environment and Children's Study, of which data for 82,919 women were analyzed after excluding women with multiple birth and pregnancy complications. PA levels were measured using the International Physical Activity Questionnaire-Short Form. The 8-Item Short Form Health Survey was used to measure outcomes. Logistic regression with multiple imputations showed that moderate PA for over 720 min/wk and vigorous PA before pregnancy were associated with poorer mental health in the first trimester (adjusted odds ratio (AOR): 1.087-1.376. Walking in the second and third trimesters was associated with better physical and mental health (AOR: 0.855-0.932). Moderate PA over 1080 min/wk and vigorous PA in the second and third trimesters were associated with poorer mental health (AOR: 1.223-1.873). Increases over 4135.4 MET-min/wk and decreases in PA levels were associated with poorer mental and physical health (AOR: 1.070-1.333). Namely, pregnant women receiving health benefits prefer continuous walking in addition to avoiding vigorous PA and excessive changes in PA levels during pregnancy.

Odds

10.3390/ijerph182111373

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Citations (3)

Polyamine as a negative regulatory substance in defense responses of soybean against the infection and nitrogen fixation by Bradyrhizobium japonicum

Springer eBooks (1997)

Takashi Ozawa Sayaka Kato Katsuko Sanai Mamami Sawamoto

Bradyrhizobium japonicum

Polyamine oxidase

Amine oxidase (copper-containing)

Polyamine

Oxidative deamination

Bradyrhizobium

10.1007/978-94-009-0047-9_227

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Gene Knockout and Metabolome Analysis of Carnitine/Organic Cation Transporter OCTN1

Pharmaceutical Research (2010)

Yukio Kato Yoshiyuki Kubo Daisuke Iwata Sayaka Kato Tomohisa Sudo

Metabolome

Ergothioneine

Solute carrier family

Gene knockout

Knockout mouse

SLCO1B1

10.1007/s11095-010-0076-z

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Citations (184)

Involvement of Multidrug Resistance-Associated Protein 2 (Abcc2) in Molecular Weight-Dependent Biliary Excretion of β-Lactam Antibiotics

Drug Metabolism and Disposition (2008)

Yukio Kato Seiko Takahara Sayaka Kato Yoshiyuki Kubo Yoshimichi Sai

In the present study, we attempted to identify the membrane permeation process(es) primarily involved in the molecular-weight-dependent biliary excretion of β-lactam antibiotics. A search of the literature indicated that the molecular weight threshold operates mainly in the transport process across bile canalicular membranes. We confirmed that biliary clearance of the model biliary-excretion-type cephalosporin cefoperazone was reduced to 10% of the control in Eisai hyperbilirubinemic rats, which are genetically deficient in multidrug resistance-associated protein (Mrp) 2, indicating that Mrp2 plays a major role as an efflux transporter on the canalicular membranes. ATP-dependent uptake of several cephalosporins including cefoperazone, cefbuperazone, cefpiramide, and ceftriaxone, all of which are mainly excreted into bile, was confirmed in membrane vesicles from Sf9 cells transfected with rat Mrp2. Both the inhibitory potency of the cephalosporins for Mrp2-mediated transport and the uptake of cephalosporins by Mrp2-expressing vesicles were molecular weight-dependent, suggesting that Mrp2 is one of the major transporters involved in molecular weight-dependent biliary excretion. An uptake study in membrane vesicles of Sf9 cells transfected with breast cancer resistance protein (Bcrp) revealed that Bcrp accepts cefoperazone, cefbuperazone, cefpiramide, cefotetan, ceftriaxone, cefotiam, cefamandole, and cefazolin as substrates, and Bcrp-mediated transport was also molecular weight-dependent, suggesting that Bcrp also contributes to molecular weight-dependent biliary excretion of β-lactam antibiotics in rats.

Moxalactam

Cefoperazone

Cefotetan

10.1124/dmd.107.019125

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Citations (68)

Five Cases of Large-cell Neuroendocrine Carcinoma of the Lung Treated with Nivolumab

Haigan (2020)

Sayaka Kato Yohei Tsunoda Ryo Kimura Masami Orinaka Shoko Miyamatsu

背景．免疫チェックポイント阻害薬の肺大細胞神経内分泌癌に対する有効性は十分に検討されていない．当院において，ニボルマブにて治療を行った肺大細胞神経内分泌癌の症例を5例経験した．症例．症例は全例男性，64～74歳の肺大細胞神経内分泌癌の5例．2例は超音波気管支鏡ガイド下縦隔リンパ節生検，3例は手術検体により診断された．5例中1例に腫瘍細胞においてprogrammed death-ligand 1の高発現を認め，その1例のみニボルマブが奏効した．結論．ニボルマブが有効な肺大細胞神経内分泌癌の症例を経験した．肺大細胞神経内分泌癌においても腫瘍細胞中のprogrammed death-ligand 1の発現率がニボルマブの効果予測因子となる可能性があり，さらなる検討が望まれる．

Neuroendocrine carcinoma

10.2482/haigan.60.1017

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Citations (1)

Nurse-led group cognitive behavioral therapy for major depressive disorder among adults in Japan: A preliminary single-group study

International Journal of Nursing Sciences (2018)

Hiroki Tanoue Naoki Yoshinaga Sayaka Kato Keiko Naono‐Nagatomo Yasushi Ishida

The prevalence and burden of disease of depression necessitates effective and accessible treatment options worldwide. Since April 2016, Japanese national health insurance has covered nurse-administered cognitive behavioral therapy (CBT) for mood disorders. However, empirical support for nurse-led CBT for depression in Asian countries, especially in Japan, is still lacking. This preliminary study aimed to examine the feasibility and acceptability of nurse-led group CBT for Japanese patients with depression. In this single-arm study, we evaluated the effects of a 6-week group CBT, led by trained nurses, on patients with major depression. The primary outcome was the Beck Depression Inventory-II (BDI-II). Assessments were conducted at the beginning and end of the intervention. Of 25 participants screened, 23 were eligible for the study (of these, three dropped out during the trial but were included in the analysis). Nurse-led group CBT led to significant improvements in the severity of depression (BDI-II, P < 0.001). The mean total BDI-II score improved from 23.1 (SD = 7.56) to 12.4 (SD = 8.57), and the pre-to post-effect size was large (Cohen's d = 1.33). After CBT, 45% of the participants were judged to be treatment responders, and 34% met the remission criteria. Our preliminary findings indicate that 6 weeks of nurse-led group CBT produced a favorable treatment outcome for individuals with major depression in a Japanese clinical setting. The results of this study might encourage more Asian nurses to provide CBT as a part of their nursing practice. Further controlled trials that address the limitations of this study are required.

Group psychotherapy

10.1016/j.ijnss.2018.06.005

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Citations (16)

Association of Maternal Total Cholesterol With SGA or LGA Birth at Term: the Japan Environment and Children’s Study

The Journal of Clinical Endocrinology & Metabolism (2021)

Kayo Kaneko Yuki Ito Takeshi Ebara Sayaka Kato Taro Matsuki

Abstract Context Maternal cholesterol is important for fetal development. Whether maternal serum total cholesterol (maternal TC) levels in midpregnancy are associated with small (SGA) or large (LGA) for gestational age independent of prepregnancy body mass index (BMI) and weight gain during pregnancy is inconclusive. Objective This work aimed to prospectively investigate the association between maternal TC in midpregnancy and SGA or LGA. Methods The Japan Environment and Children’s Study is a nationwide prospective birth cohort study in Japan. Participants in this study included 37 449 nondiabetic, nonhypertensive mothers with singleton birth at term without congenital abnormalities. Birth weight for gestational age less than the 10th percentile and greater than or equal to the 90th percentile were respectively defined as SGA and LGA by the Japanese neonatal anthropometric charts. Results The mean gestational age at blood sampling was 22.7 ± 4.0 weeks. After adjustment for maternal age, sex of child, parity, weight gain during pregnancy, prepregnancy BMI, smoking, alcohol drinking, blood glucose levels, household income, and study areas, 1-SD decrement of maternal TC was linearly associated with SGA (odds ratio [OR]: 1.20; 95% CI, 1.15-1.25). In contrast, 1-SD increment of maternal TC was linearly associated with LGA (OR: 1.13; 95% CI, 1.09-1.16). Associations did not differ according to prepregnancy BMI and gestational weight gain (P for interaction > .20). Conclusion Maternal TC levels in midpregnancy were associated with SGA or LGA in a Japanese cohort. It may help to predict SGA and LGA. Favorable maternal lipid profiles for fetal development must be explored.

10.1210/clinem/dgab618

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Citations (11)

Protein arginine methyltransferase 5 (PRMT5) is a novel coactivator of constitutive androstane receptor (CAR)

Biochemical and Biophysical Research Communications (2015)

Yuichiro Kanno Jun Inajima Sayaka Kato Maika Matsumoto Chikako Tokumoto

Constitutive androstane receptor

Pregnane X receptor

10.1016/j.bbrc.2015.02.085

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Citations (5)

Functional Expression of Organic Cation/carnitine Transporter 2 (OCTN2/SLC22A5) in Human Brain Capillary Endothelial Cell Line hCMEC/D3, a Human Blood-brain Barrier Model