Kunio Kangouri

Taisho Pharmaceutical (Japan)

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SADAFUMI OMURA

Kitasato University

Li Lian-niang

Chinese Academy of Medical Sciences & Peking Union Medical College

Hiroshi Hara

Fuji Women's University

T. Miyoshi

Kumamoto University

Kazuhiko Sugita

Taisho Pharmaceutical (Japan)

Shinjuro Namiki

Taisho Pharmaceutical (Japan)

Takatoshi Nagate

Uehara Memorial Foundation

Akiko Ikeda

Yamato Municipal Hospital

Hong Xue

Affiliated Hospital of Guizhou Medical University

Xue Hong

Chinese Academy of Medical Sciences & Peking Union Medical College

Cooperative Institutions

Taisho Pharmaceutical (Japan)

Chinese Academy of Medical Sciences & Peking Union Medical College

The University of Tokyo

Hokkaido University

University of Tsukuba

Hong Kong University of Science and Technology

University of Hong Kong

Kumamoto University

Yamaguchi University

Gifu University

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Cholesterol Biosynthesis Inhibitory Activities of Novel Triterpenoid Acids fromKadsura heteroclitaandK. longipedunculata

Agricultural and Biological Chemistry (1990)

Kunio Kangouri T. Miyoshi Akiko Ikeda SADAFUMI OMURA Li Lian-niang

The effects of twelve novel triterpenoid acids isolated from the ethanolic extract of the stems of Kadsura heteroclita and A. longipedunculata, Chinese folk medicines, and three other novel triterpenoid acids semi-synthesized on cholesterol biosynthesis were examined. (24Z)-3-Oxo-lanosta-8,24-dien-26-oic acid (3-oxo-LA) was most active in depressing cholesterol biosynthesis from [2-14C] mevalonate in a 10,000 × g supernatant fraction of rat liver homogenate. It was suggested from the TLC analysis of radio-labeled products that these compounds inhibit the demethylation of lanosterol. Some triterpenoid acids including 3-oxo-LA also inhibited cholesterol biosynthesis from [1-14C]acetate in primary cultures of rat liver cells.

Lanosterol

Demethylation

Terpene

Mevalonic acid

10.1080/00021369.1990.10870055

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Citations (0)

Studies on the .ALPHA.-glucoside hydrolase inhibitor, adiposin. III. .ALPHA.-Glucoside hydrolase inhibitory activity and antibacterial activity in vitro.

The Journal of Antibiotics (1982)

Kunio Kangouri Shinjuro Namiki Takatoshi Nagate Hiroshi Hara Kazuhiko Sugita

Glucoside

Alpha-glucosidase

Gram-Negative Bacteria

10.7164/antibiotics.35.1160

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Citations (10)

PA53 NEOKADSURANIC ACID A AND SECO-NEOKADSURANIC ACID A, THE FIRST TWO TRITERPENOIDS WITH 14 (13→12) ABEO LANOSTANE SKELETON FROM KADSURA HETEROCLITA

International Symposium on the Chemistry of Natural Products (1988)

Kunio Kangouri T. Miyoshi Akira Kawashima Akiko Ikeda Taku Mizutani

Lanostane

Skeleton (computer programming)

Source

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Citations (0)

Journal of the Japanese Society of Starch Science (1980)

Shinjuro Namiki Kunio Kangouri Takatoshi Nagate Kazuhiko Sugita Hiroshi Hara

TAI-A and TAI-B showed inhibitory activities against sucrase, maltase and isomaltase isolated from hog small intestine according to the method of Dahlqvist. TAI suppressed the increase of the blood glucose level of fasting mice administered with maltose. TAI suppressed the increase of the blood glucose level and the secretion of insulin of rats which were fasted and then forced-fed cooked corn starch, because of the inhibition against the starch digestion in the small intestine. The suppression of the increase in the body weight was observed in the 3 months toxicity test on the groups which were given diet containing 1.82 and 908 GIU/g of TAI, respectively . Hematological and histopathological examinations did not reveal any remarkable difference among all the experimental animals. TAI inhibited the growth of some anaerobic bacteria belonging to Clostridia, but did not show any inhibitory activity against other anaerobic bacteria. TAI and maltotriose showed an synergistic effect on the antibacterial activity.

Maltase

Sucrase

Alpha-glucosidase

Resistant Starch

Disaccharidase

Digestion

10.5458/jag1972.27.107

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Citations (0)

Studies on the .ALPHA.-glucoside hydrolase inhibitor, adiposin. I. Isolation and physicochemical properties.

The Journal of Antibiotics (1982)

Shinjuro Namiki Kunio Kangouri Takatoshi Nagate Hiroshi Hara Kazuhiko Sugita

Glucoside

Hydrolase

Isolation

Alpha (finance)

10.7164/antibiotics.35.1234

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Citations (49)

Journal of the Japanese Society of Starch Science (1979)

Shinjuro Namiki Kunio Kangouri Takatoshi Nagate Kazuhiko Sugita Hiroshi Hara

The novel basic amylase inhibitors, TAI-A and TAI-B, were isolated from the cultured broth of Streptomyces calvus TM-521. The molecular weight of TAI-A and TAI-B were estimated to be 950-1050 and 650-700, respectively. Both of TAI-A and TAI-B were a kind of oligosaccharide group amylase inhibitor, and contained glucose as their main constituent, and they did not have any methyl groups in their molecules, judging from their NMR spectra. TAI-A and TAI-B showed inhibitory activities against glucoamylase, bacterial saccharif ying a-amylase, salivary a-amylase and hog pancreatic a-amylase. Both amylase inhibitors apparently suppressed the increase of the blood glucose level of the fasting mice administered with cooked starch (1 g/kg)or sucrose(2.5 g/kg). They did not show any intravenous acute toxicity on mice at the dose less than 1 g/kg of body weight. TAI-A and TAI-B mainly inhibited the growth of bacteria belonging to Enterobacteriaceae of gram-negative bacteria and phytopathogenic fungi, and showed the synergistic effect with maltooligosaccharide in the antibacterial activities. Antibacterial and antiphytopathogenic fungi activities of TAI-A and TAI-B were inhibited by the addition of various saccharides.

Oligosaccharide

10.5458/jag1972.26.134

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Citations (1)

Isolation and Structure Elucidation of Neokadsuranic Acid A, the First Triterpenoid with the 14 (13→12)abeoLanostane Skeleton, and (24Z)-3-Oxo-lanosta-8,24-dien-26-oic Acid¹

Planta Medica (1989)

Kunio Kangouri T. Miyoshi Akira Kawashima Akiko Ikeda Taku Mizutani

Neokadsuranic acid A, which is the first triterpenoid with the 14(13-->12) ABEO lanostane skeleton, was isolated from KADSURA HETEROCLITA together with (24 Z)-3-oxo-lanosta-8,24-dien-26-oic acid. The present paper deals with the isolation and structure elucidation of these two new compounds.

Lanostane

Skeleton (computer programming)

Folk medicine

Isolation

10.1055/s-2006-962011

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Citations (30)

Triterpenoid Acids fromKadsura longipedunculata. Neokadsuranic Acids B and C: Two Novel Triterpenoids with 14 (13 → 12)abeo-Lanostane Skeletons

Planta Medica (1989)

Li Lian-niang Xue Hong Kunio Kangouri Akiko Ikeda SADAFUMI OMURA

Six triterpenoid acids were isolated from the stems of KADSURA LONGIPEDUNCULATA, collected in Kuangxi province. Four of them were new compounds and assigned as (24 Z)-3-oxo-12alpha-acetoxylanosta-8,24-dien-26-oic acid ( 1), (24 Z)-3-oxo-12alpha-hydroxylanosta-8,24-dien-26-oic acid ( 2), (24 Z)-3-oxo-14(13-->12) ABEO-lanosta-8,13(18),24-trien-26-oic acid ( 3), and (24 Z)-3-oxo-13beta-hydroxy-14(13-->12) ABEO-lanosta-8,24-dien-26-oic acid ( 4). Compounds 3 and 4 were named neokadsuranic acids B and C, respectively.

Lanostane

Folk medicine

10.1055/s-2006-962010

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Citations (18)

Studies on the .ALPHA.-glucoside hydrolase inhibitor, adiposin. IV. Effect of adiposin on intestinal digestion of carbohydrates in experimental animals.

The Journal of Antibiotics (1982)

Shinjuro Namiki Kunio Kangouri Takatoshi Nagate Hiroshi Hara Kazuhiko Sugita

Glucoside

Alpha-glucosidase

Digestion

Alpha (finance)