Lead-free halide perovskites have gained attention in recent years as viable materials with more distinctive characteristics than conventional semiconductor materials. Lead-free Cs3Bi2I9 colloidal perovskite nanocrystal is chosen to eliminate its single-phase synthesis difficulty and implement the material in bioimaging applications. Nanostructured Cs3Bi2I9 perovskite composites were coated with a thin coating of SiO2 by an in situ tetraethyl orthosilicate/(3-aminopropyl)trimethoxysilane injection growth method to enhance their stability in aqueous medium and biocompatibility. Single-phase novel Cs3Bi2I9 colloidal perovskite nanocrystal synthesis was successfully developed and optimized by adopting different synthetic conditions with varied experimental parameters. Characterization studies, including X-ray diffractometry and transmission electron microscopy, confirm the hexagonal structure of Cs3Bi2I9 crystals and their cubic morphology. A broad emission peak in the red region was captured for pure and composite perovskite under different excitation wavelengths and was observed using a UV-visible spectrophotometer. Bioimaging of Cs3Bi2I9@SiO2 composites incorporated with L929 cells was conducted using an inverted fluorescence microscope under blue and green excitation. The results obtained from bioimaging studies indicated that the Cs3Bi2I9@SiO2 nanocomposites entered the cell field and exhibited an emission under excitation. The non-toxic behavior of the synthesized Cs3Bi2I9@SiO2 composites was demonstrated using MTT cytotoxicity assay in L929 fibroblast mouse cells, showing better cell compatibility.
Abstract Hierarchical structure transformation and surface modification of solvothermal method synthesized SnS with oleic acid in ethylene glycol solvent were discussed in detail. The structural, optical, and morphology of as prepared SnS samples were examined by X-ray diffraction (XRD), Raman Spectroscopy, and Field Emission Scanning Electron Microscopy (FE-SEM). XRD verifies the orthorhombic crystal structure of the SnS phase for all synthesized samples. Single-phase nature of synthesized particles was confirmed with Raman characterization. Morphology evolution of SnS from regular to hierarchical structures upon adding oleic acid is performed through FE-SEM analysis. Junction diodes p-SnS/n-Si fabricated with different oleic acid concentrations (0.5, 1.5, and 2.5 mL) synthesized SnS particles show better photo-response, which can be used in photodiode applications.
ABSTRACT This research is based on a Systematic Evolution of Ligands by EXponential enrichment, also referred to as in vitro selection against the extracellular domain of human interleukin-17 receptor A (IL-17RA). Pull-down assay via quantitative polymerase chain reaction and chemiluminescence detection showed that the cloned RNA with the enriched sequence bound to human IL-17RA and inhibited the interaction between IL-17RA and human interleukin-17A (IL-17A). We also revealed that the newly discovered IL-17RA-binding RNA aptamer bound to cellular IL-17RA, inhibited the cellular IL-17RA/IL-17A interaction, and antagonized cellular IL-17A signaling.
We report novel, ribosomally incorporatable, and intramolecularly cysteine-reactive fluorobenzoic acid-derived linkers for SELEX of mRNA-displayed unnatural peptides, which spontaneously cyclized via intramolecular nucleophilic aromatic substitutions forming thioethers. With this strategy we identified several novel PCSK9-binding peptides.
The effect of variant high boiling point solvent combinations in the synthesis and photo-sensing characteristics of tin disulfide (SnS2) thin nanosheets were investigated.
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