An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
Abstract o‐Alkynylanilines bearing a suitable leaving group (generally o‐fluorobenzoyl) at the nitrogen are coupled with oxadiazoles to produce N‐unsubstituted indoles directly.
Transition metal-catalyzed aromatic functionalization reactions are highly important for the construction of various organic fine chemicals. In particular, the direct C(sp2)-H bond transformation of (hetero)aromatics is currently recognized to be highly useful in organic synthesis, as it can realize short-step sequences leading to target molecules. We have been studying on aromatic cross-coupling reactions through C-H bond activation/cleavage leading to new C-C and C-heteroatom bonds. The research strategies involve directing group control and utilization of unique properties of reaction substrates and catalysts, which enable efficient regioselective direct coupling reactions. In this account, our recent work is briefly summarized, mainly focused on the synthetic methods of benzo-fused multi-ring heterocyclic compounds of potent interest in pharmaceutical and material chemistry. We have been studying on aromatic cross-coupling reactions through C-H bond activation/cleavage leading to new C-C and C-heteroatom bonds. In this account, our recent work is briefly summarized, mainly focused on the development of synthetic methods of multi-ring benzo-fused heterocyclic compounds of potent interest in pharmaceutical and material chemistry.
A ligand-controlled regiodivergent Cu-catalyzed aminoboration of unactivated terminal alkenes with diboron reagents and hydroxylamines has been developed. The xantphos-ligated CuCl complex guides the boron and amino groups to the terminal and internal positions, respectively. On the other hand, the opposite regioisomers are selectively obtained under the N-heterocyclic carbene-based IPrCuBr catalysis. The two Cu catalysts can readily transform simple and abundant terminal alkenes into highly valuable β-borylalkylamines regiodivergently.
In the synthesis of "composite" heteroarene-fused COTs, reported in this Communication, compound 10 was obtained as asingle isomer (eq.1).However,compound 12 (eq.2) was am ixture of two possible regioisomers (ca.1:1).The Nand CH in the isomers cannot be distinguished in the X-ray crystallography analysis.The 13 CNMR chart deposited in the Supporting Information was confused with that of adifferent isomer consisting of two thiophene and two thiazole rings ,2,5,8,3':5,6;3'',2'':7,8]cycloocta[2,]bis(thiazole), prepared by another coupling method which will be reported in due course.The 13 CNMR spectrum is replaced with the correct one (the original 1 HNMR spectrum was correct) in the Supporting Information available online along with this Communication.This correction does not change the conclusions of the manuscripts.
