Gamal A. Mohamed

King Faisal Specialist Hospital & Research Centre

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Sabrin R. M. Ibrahim

Batterjee Medical College

238

Hossam M. Abdallah

King Abdulaziz University

Shaimaa G. A. Mohamed

Alfaisal University

Abdulrahim A. Alzain

University of Gezira

Ali M. El-Halawany

Cairo University

Dina S. El‐Agamy

Mansoura University

Diaa T. A. Youssef

King Abdulaziz University

Samir A. Ross

University of Mississippi

Abdulrahman E. Koshak

King Abdulaziz University

Ahmed Ashour

Mansoura University

Cooperative Institutions

King Abdulaziz University

128

Ain Shams University

100

Mansoura University

100

Cairo University

Al-Azhar University

Assiut University

Taibah University

Zagazig University

King Faisal Specialist Hospital & Research Centre

King Saud University

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Production of Bio-ethanol from sugar beet pulp using recombinant E. coli and S. cereviceae

Egyptian Sugar Journal (2022)

Abd El-Naser Zohri Gamal A. Mohamed E. S. E. Hafez Fahmy Fahmy

Ethanol is one of the most important biofuels that can be produced from different renewable sources.Sugar beet pulp (SBP) is used as renewable and cheap raw material for ethanol production.SBP is the by-product of the sugar industry from sugar beet that is used as animal feed after processing (pressing, dehydration, and pelletizing).Ethanol from SBP will be more profitable value than the other uses as animal feed.The two highest cellulases producer isolates S11 and S88 from the previous work were subjected to DNA identification using the 16S rRNA gene.16S rRNA is tool used to identify the origin, classification, evolutionary and relationship history.The isolates S11 (Streptomyces sp.strain FDZH12) and S88 (Streptococcus mitis strain FDZH16) had been submitted to EMBL and their accession numbers are OK033363 and OK033364, respectively.Cellulase gene from S11 Streptomyces FDZH12 then cloned into E.coli to produce superior strain for cellulases production.The recombinant E. coli was confirmed by colony PCR using gene-specific primers of cellulases.Ethanol production from SBP is achieved through three steps: first, acid-base treatment for SBP and then the resulting cellulose content hydrolyzed to fermentable sugar using genetically engineered E.coli cloned by cellulases enzyme.Finally, the fermentable sugar is fermented to ethanol using S.cereviciae FDZH2O The weight of dried SBP after acid-base treatment was 45.5 % of the original dried SBP.Cellulose contents of untreated SBP were 27.95 % and reached 84.22 % after acid-base treatment (842.2g/kg).The maximum yields of glucose by the recombinant E.coli after 24 hours of saccharification of treated SBP were 28.36 g/50 g of acid base treated SBP (67.52% of their cellulose content).

Beet pulp

10.21608/esugj.2022.152681.1016

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Citations (1)

Alliuocide G, a new flavonoid with potent α-amylase inhibitory activity from Allium cepa L.

ARKIVOC (2008)

Gamal A. Mohamed

Chemical investigation of the ethyl acetate fraction of the dried outer scales of Allium cepa L. afforded one new flavonoid named alliuocide G, together with four known compounds.Their structures were unambiguously established on the bases of NMR spectroscopy ( 1 H, 13 C, DEPT, and HMBC) and mass spectrometry.The isolated compounds showed potent α-amylase inhibitory activities, in addition the new compound had antioxidant activity.

10.3998/ark.5550190.0009.b20

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Citations (32)

Lupeol-3-O-decanoate, a new triterpene ester from Cadaba farinosa Forssk. growing in Saudi Arabia

Medicinal Chemistry Research (2013)

Nawal M. Al-Musayeib Gamal A. Mohamed Sabrin R. M. Ibrahim Samir A. Ross

Lupeol

Ursolic acid

10.1007/s00044-013-0536-1

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Citations (32)

Outcome of Patients with Cervical and Vaginal Stump Carcinomas Treated with More Conservative Surgical Approaches: a 9-Year Experience of a Tertiary Oncology Center

Indian Journal of Surgical Oncology (2017)

Mohamed Hegazy Ashraf Khater Gamal A. Mohamed Sherif Kotb Waleed Elnahas

Surgical oncology

Pelvic exenteration

Surgical margin

Resection margin

10.1007/s13193-017-0640-7

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Citations (1)

Fungal Naphthalenones; Promising Metabolites for Drug Discovery: Structures, Biosynthesis, Sources, and Pharmacological Potential

Toxins (2022)

Sabrin R. M. Ibrahim Sana A. Fadil Haifa A. Fadil Bayan A. Eshmawi Shaimaa G. A. Mohamed

Fungi are well-known for their abundant supply of metabolites with unrivaled structure and promising bioactivities. Naphthalenones are among these fungal metabolites, that are biosynthesized through the 1,8-dihydroxy-naphthalene polyketide pathway. They revealed a wide spectrum of bioactivities, including phytotoxic, neuro-protective, cytotoxic, antiviral, nematocidal, antimycobacterial, antimalarial, antimicrobial, and anti-inflammatory. The current review emphasizes the reported naphthalenone derivatives produced by various fungal species, including their sources, structures, biosynthesis, and bioactivities in the period from 1972 to 2021. Overall, more than 167 references with 159 metabolites are listed.

Antimycobacterial

Antiparasitic

10.3390/toxins14020154

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Citations (16)

Effect of heat treatment on the structural and optical properties of CuInTe2 thin films

Journal of Materials Science (1993)

A.M. Abo El Soud T. A. Hendia L. I. Soliman Hamdia A. Zayed Gamal A. Mohamed

Lattice constant

Vacuum evaporation

10.1007/bf01191950

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Citations (20)

Activity and Structure Elucidation of Ceramides

Current Bioactive Compounds (2013)

Ehab S. Elkhayat Gamal A. Mohamed Sabrin R. M. Ibrahim

Ceramide, a derivative of sphingolipid breakdown products, acts as second messenger for multiple extracellular stimuli including growth factors, chemical agents, and environmental stresses. They have been shown to be crtically involved in various biological processes, including differentiation, senescence, cell-cycle arrest, proliferation, and apoptosis. Ceramide molecules form distinct domains in the cell membrane, which may serve to re-organize cellular receptors and signaling molecules. Because of their promising biological activities and applications, here we focus on: biosynthesis, existence, importance, and structure elucidation, as well as representative examples concerning their structure and activity. Keywords: Ceramide, sphingolipid, biological activity, identification, breakdown products, multiple extracellular stimuli, Hydrolysis, microbial pathogenesis, emporal organization, mitochondrial transmembrane potential

Sphingolipid

Second messenger system

Cell Signaling

10.2174/1573407211208040006

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Citations (21)

Blepharisides A and B, new flavonol glycosides from Blepharis ciliaris growing in Saudi Arabia

Phytochemistry Letters (2014)

Gamal A. Mohamed Sabrin R. M. Ibrahim Ehab S. Elkhayat Samir A. Ross Hanaa M. Sayed

Acanthaceae

CCL4

Anti-inflammatory

10.1016/j.phytol.2014.12.018

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Citations (19)

Phenolics from Garcinia mangostana Inhibit Advanced Glycation Endproducts Formation: Effect on Amadori Products, Cross-Linked Structures and Protein Thiols

Molecules (2016)

Hossam M. Abdallah Hany M. El‐Bassossy Gamal A. Mohamed Ali M. El-Halawany Khalid Z. Alshali

Accumulation of Advanced Glycation Endproducts (AGEs) in body tissues plays a major role in the development of diabetic complications. Here, the inhibitory effect of bioactive metabolites isolated from fruit hulls of Garcinia mangostana on AGE formation was investigated through bio-guided approach using aminoguanidine (AG) as a positive control. Including G. mangostana total methanol extract (GMT) in the reaction mixture of bovine serum albumin (BSA) and glucose or ribose inhibited the fluorescent and non-fluorescent AGEs formation in a dose dependent manner. The bioassay guided fractionation of GMT revealed isolation of four bioactive constituents from the bioactive fraction; which were identified as: garcimangosone D (1), aromadendrin-8-C-glucopyranoside (2), epicatechin (3), and 2,3′,4,5′,6-pentahydroxybenzophenone (4). All the tested compounds significantly inhibited fluorescent and non-fluorescent AGEs formation in a dose dependent manner whereas compound 3 (epicatechin) was found to be the most potent. In search for the level of action, addition of GMT, and compounds 2–4 inhibited fructosamine (Amadori product) and protein aggregation formation in both glucose and ribose. To explore the mechanism of action, it was found that addition of GMT and only compound (3) to reaction mixture increased protein thiol in both glucose and ribose while compounds 1, 2 and 4 only increased thiol in case of ribose. In conclusion, phenolic compounds 1–4 inhibited AGEs formation at the levels of Amadori product and protein aggregation formation through saving protein thiol.

Garcinia Mangostana

Amadori rearrangement

Bovine serum albumin

Thiol

Ribose

10.3390/molecules21020251

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Citations (61)

A randomized clinical trial comparing two levothyroxine regimens during Ramadan fasting in thyroidectomized patients

Journal of the Endocrine Society (2024)

Ali S. Alzahrani Noha Mukhtar Zahrah Abbas Alhammad Lulu Abdulaziz Alobaid Abdulrhman Jaber Hakami

Abstract Context For Muslim patients on levothyroxine (L-T4) therapy, the best approach for L-T4 intake during Ramadan fasting remains unclear. Objective We compared 2 practical approaches for L-T4 intake during Ramadan. Methods We randomly assigned 69 patients (21 males, 48 females, median age 44 years) with differentiated thyroid cancer (DTC) who underwent thyroidectomy in the past and are on stable LT4 doses to 2 arms. Arm A (33 patients) ingested their pre-Ramadan L-T4 dose at the evening meal and ate immediately. Arm B (36 patients) increased their pre-Ramadan dose by 25 µg if their regular L-T4 dose was ≤150 µg/day or by 50 µg if their pre-Ramadan dose was >150 µg/day and ate immediately. Results At the beginning of Ramadan (baseline), the median thyrotropin (TSH) level and the numbers of patients in euthyroidism, subclinical hyperthyroidism (Shyper), or subclinical hypothyroidism (Shypo) were comparable between the 2 arms (P = .69 and P = .65, respectively). At the end of Ramadan, in arm A there were 17 (51.5%), 3 (9.1%), and 13 (39.4%) patients in euthyroidism, Shyper, and Shypo compared with 17 (47.2%), 14 (38.9%), and 5 (13.9%) patients, respectively, in arm B (P = .005). The mean ± SD TSH levels in arms A and B at the end of Ramadan were 5.6 ± 6.0 mU/L and 1.67 ± 2.6 mU/L, respectively (P = .0001). Conclusion No overt thyroid dysfunction developed but there were more cases of Shypo in arm A and Shyper in arm B. Arm B achieved desirable levels of TSH (normal or slightly suppressed) in 86% of cases and might be a preferable approach, especially for patients who need TSH suppression (eg, DTC).

Levothyroxine

10.1210/jendso/bvae173

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