Azza Mohamed Ahmed Said

Ain Shams University

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S. Makki

Texas A&M University at Qatar

J. Millet

Génétique et Immunologie des Maladies Parasitaires

Abdelrahman Gaber Salman

Ain Shams University

Patrice Muret

Université de franche-comté

Maha Nasr

Ain Shams University

Ph. Humbert

Hôpital Saint-Jacques

Samira El-Sayad

Fayoum University

Hanan Hussein Shehata

Ain Shams University

Yaser Abdelmageuid Elzankalony

Ain Shams University

Mohamed Omar Yousif

Ain Shams University

Cooperative Institutions

Ain Shams University

Hôpital Saint-Jacques

Cairo University

Université de franche-comté

Centre Hospitalier Universitaire de Besançon

Ain Shams University Hospital

Heliopolis University

Service de la Santé Publique

Alexandria University

Inserm

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The cornea: corneal complications of spring catarrh.

PubMed (1975)

Azza Mohamed Ahmed Said Sohail Abbas

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Evaluation of the role of multifocal electroretinography in early detection of hydroxychloroquine retinal toxicity in patients with connective tissue diseases

Yehia Mohamed El Gamal Azza Mohamed Ahmed Said Zeinab Ebraheem Hasan Mohammed Ahmed Mahmoud Shoukri

Hydroxychloroquine

Electroretinography

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Safety and efficacy of posterior sub-Tenon’s carboplatin injection versus intravitreal melphalan therapy in the management of retinoblastoma with secondary vitreous seeds

International Journal of Ophthalmology (2018)

Azza Mohamed Ahmed Said Mohamed Aly Hazem Rashed Anwaar Mahmoud Rady

AIM: To evaluate the safety and efficacy of posterior sub-Tenon's carboplatin injection compared to intravitreal melphalan injection in the management of retinoblastoma (RB) with secondary vitreous seeds. The outcome measures were vitreous seeds regression, need for other treatment modalities to achieve ocular salvage and treatment side effects. METHODS: A prospective interventional comparative nonrandomized study included RB eyes developed secondary vitreous seeds during the period of follow up. They subdivided into two groups: study group I where posterior sub-Tenon's carboplatin (20 mg/2 mL) was injected and study group II where intravitreal melphalan (20 μg /0.1 mL) was injected. The injections repeated every 2-4wk. RESULTS: Thirty-three eyes were included in the study. Seventeen eyes (16 patients) in study group I and 16 eyes (16 patients) in study group II. Ten eyes (30.3%) were completely salvaged following local chemotherapies. Ocular salvage was 23.5% following posterior sub-Tenon's carboplatin injection versus 37.5% following intravitreal melphalan raised to 47.1% and 75% with addition of external beam radiotherapy (EBR) with no statistically significant difference between the study groups (P=0.16). A statistically significant correlation was found between ocular salvage rate and type of vitreous seeds either dust, spheres and clouds (r=0.42, P=0.015) and eyes harbor new solid tumor growth (r=0.35, P=0.045). The mean and median follow up periods following local chemotherapy injections were 2.0y in the study group I and 2.37y in the study group II. Few complications were reported: periorbital edema in all eyes and ocular motility disturbances in 13 eyes (76.5%) following posterior sub-Tenon's carboplatin injection. Vitreous hemorrhage developed in 2 eyes (12.5%) and localized retinopathy in 5 eyes (31.25%) following intravitreal melphalan. CONCLUSION: Local chemotherapy for treatment of RB with secondary vitreous seeds is safe and can salvage 30.3% of eyes without EBR. There is a superiority of intravitreal melphalan in ocular salvage however, no statistically significant difference between both groups.

Carboplatin

Retinoblastoma

Melphalan

Mortise and tenon

Vitreous hemorrhage

10.18240/ijo.2018.03.15

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OBSERVATION OF CENTRAL MACULAR THICKNESS AND MICROVASCULATURE BY OPTICAL COHERENCE TOMOGRAPHY AND OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IN AN AMBLYOPIC PATIENT

International Journal of Advanced Research (2023)

Marwa S.M. Ibrahim M.Sc.Azza Mohamed Ahmed Said Islam A.M. Soliman Mahmoud A. El Samkary

Purpose: Documented the macular area changes regarding thickness and vascularity on an amblyopic patient by optical coherence tomography and optical coherence tomography angiograph. Patients and methods: A case control observational study. AllPatients were attended to Ain shams university clinic and the clinic of Ophthalmology Department of Re- search Institute of Ophthalmology in period between October 2020 to May 2021.the study included 40 patients, age between 7-18y, with unilateral amblyopic eye and divided into 4 groups each group 10 patients, unilateral amblyopic with strabismus, anisometropia, sensory deprivation compared to control study. The patients excluded with history prematurity, trauma, neurologic or systemic disease, uncooperative patients, eccentric fixation, and patients with refractive errors more than 6 Diopters. The thickness and vascularity of macular area were investigated and documented byoptical coherence tomography (OCT) and optical coherence tomography angiograph (OCTA). Results: The central thickness (1mm) of macula in all groups were non-significant compared with the control group except in sensory amblyopic groupthere was a significant increase in the thickness compared to control group with p -value 0.033.The vascularity of FAZ area, superficial capillary plexus (SCP) and deep capillary plexus (DCP), are not statistically significant (p-value was 0.0412 & 0.154) respectively. Conclusion: Thestudy helps in understanding the changes in central macular thickness and FAZ microvasculature by OCT and OCTA that may play a role in pathophysiology and the management of different types of an amblyopic pediatric patient.

Vascularity

Microangiography

Anisometropia

10.21474/ijar01/16298

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Spectrofluorimetric determination of 5‐methoxypsoralen pharmacokinetic in patients' serum

Experimental Dermatology (1997)

Azza Mohamed Ahmed Said S. Makki Patrice Muret G Toubin Ph. Humbert

Abstract In medicine, psoriasis and vitiligo are most often treated with PUVA therapy (psoralen plus ultraviolet A). The determination of psoralen in patients' blood is necessary, as it is admitted that the therapecutic efficiency depends on drug concentration in patients' serum. The amount of UVA to administer is inversely proportional to serum peak concentration. High performance liquid chromatography (HPLC) and gas chromatography are the most employed methods for determining psoralens in patients' serum. The 2 techniques are precise and very sensitive, but time consuming. The aim of this paper is to propose a suitable method which is rapid and simple. It is a spectrofluorimetric technique for 5‐methoxypsoralen (5‐MOP) determination in the serum of patients treated with PUVA therapy. 5‐MOP extraction was carried out with an heptane/dichloromethane mixture (4/1; v/v), according to the Stolk method (1980). A calibration curve (CC) was plotted from 5‐MOP concentrations (range 50, 100, 200, 300, 400, 500 ng/ml). The CC was linear with a good coefficient of correlation: r = 0.9971, and a suitable coefficient of variation (CV) of 7.0%. The recovery of the method ranged from 85.3±4.2 to 108±4.1%/. The assay precision gave a CV ranging from 0.10 to 6.90%, with an error inferior to ± 10%. The method did not reveal any interference from serum components on the 5‐MOP emission wavelength. The limit of detection of 5‐MOP was 15 ng/ml. The proposed procedure was proved to be appropriate for a rapid determination of 5‐MOP in patients' serum. This technique could also be employed for other proralens used in PUVA therapy (e.g., 8‐methoxypsoralen.)

Coefficient of variation

10.1111/j.1600-0625.1997.tb00147.x

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Serum Selenium Status in Egyptians Patients who had Graves’ Disease with and without Ophthalmopathy

QJM (2024)

Ghada Hasanin M S Mohamed Maram Mohamed Maher Hanan Mahmoud Ali Hany Khairy Mansour

Abstract Objective Selenium is effective in improving quality of life and reducing the progression of active Graves’ orbitopathy. The effect of correcting relative selenium deficiency on improving Graves’ orbitopathy is unknown, as baseline selenium levels have not previously been measured. The study aims to determine whether serum selenium levels are reduced in patients with Graves’ disease with orbitopathy (GO) compared with without orbitopathy (GD). Design A prospective, case–control study performed between 2019 and 2021 at endocrine and ophthalmology clinics in Ain SHams University, Cairo. Subjects A total of 75 subjects, 25 as control and a total of 50 patients with Graves’ disease participated in the study: 25 with Graves’ orbitopathy and 25 without Graves’ orbitopathy. Measurements Serum selenium levels in all groups. Results Mean serum selenium levels were significantly lower in GO (16.6 +- 7.5 ng/ml) than in GD (42.9 +- 8.2 ng/ml) with (P < 0.001). Mean selenium levels appeared to decrease in parallel with increasing severity of GO; selenium level was 30-55 ng/ml in GD, 21-28ng/ml in mild GO, 18-22 ng/ml in moderate GO and 5-16 ng/ml in severe GO (P < 0.001). Conclusion Serum selenium levels are lower in patients with GO compared with GD in an Egyptian study population with marginal selenium status. selenium deficiency may be an risk factor for orbitopathy in patients with Graves’ disease.

10.1093/qjmed/hcae070.301

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An unusual case of coronary artery fistula to the pulmonary artery, diagnosed with 64-MDCT coronary angiography

The Egyptian Journal of Radiology and Nuclear Medicine (2013)

Azza Mohamed Ahmed Said I. Helmy Kh. Hashem T. EssamEldin

This report describes a case of complex coronary–pulmonary artery fistula with one feeding vessel from the proximal part of the right coronary. The complex anatomy of the fistula was shown in detail by multidetector computed tomography using multiplanar reconstruction and 3D volume rendering techniques. Traditionally, conventional angiography has been used for the diagnosis of coronary anomalies. With more frequent use of 64-row multi-detector computed tomography (CT) in chest and cardiac imaging, the number of incidentally found coronary artery fistulas has been increasing.

Multidetector computed tomography

Computed Tomography Angiography

Coronary arteries

10.1016/j.ejrnm.2013.07.012

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Citations (1)

Comparative study of 3 intracorneal implant types to manage central keratoconus

Journal of Cataract & Refractive Surgery (2018)

Mohamed Omar Yousif Azza Mohamed Ahmed Said

Purpose: To compare the visual acuity, refraction, corneal topography, and corneal asphericity of intrastromal corneal implantation of Keratacx 160-degree 2 symmetrical ring segment, the Keratacx 320-degree near-total ring, and the Myoring continuous intracorneal ring (ICR) in central keratoconus. Setting: Ophthalmology Department, Ain Shams University, Cairo, Egypt. Design: Prospective case series. Methods: Surgeries were performed using a femtosecond laser for tunnel creation for the 160-degree 2-segment device (Group 1) and the 320-degree near-total ring (Group 2), and for pocket creation for the ICR (Group 3). The preoperative and 6-month postoperative uncorrected (UDVA) and corrected (CDVA) distance visual acuities, spherical equivalent (SE), corneal and refractive astigmatism, keratometry (K) readings, and Q value using topography images were acquired. Results: The study included 73 eyes. No statistically significant differences were found in the preoperative parameters between groups (P > .05). The postoperative UDVA, CDVA, SE, corneal and refractive astigmatisms, K readings, and Q value were statistically better than the preoperative parameters in all study groups (P < .01). A statistically significant increase in the median UDVA and CDVA occurred in Group 2 compared with Group 1 (P < .01). Groups 2 and 3 had a more effective reduction in SE (P < .01). No statistically significant difference was found in the postoperative changes in the corneal and refractive cylinders, mean and maximum K readings, and corneal asphericity between the study groups (P > .05). Conclusions: All devices were effective in improving UDVA, CDVA, refraction, K readings, and corneal asphericity. The 320-degree segment and ICR improved UDVA and SE more than the 2-segment device.

Astigmatism

Corneal pachymetry

10.1016/j.jcrs.2017.12.020

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Corneal sensitivity, ocular surface health and tear film stability after punctal plug therapy of aqueous deficient dry eye

International Journal of Ophthalmology (2016)

Azza Mohamed Ahmed Said Mona Elsayed Farag Tarek Mohamed Abdulla Othman Ali Othman Ziko Wesam M. Osman

To evaluate the effect of punctal occlusion using thermosensitive (smart plug) versus silicone plug for management of aqueous deficient dry eye on corneal sensitivity, ocular surface health and tear film stability.A comparative prospective interventional case study included 45 patients with bilateral severe form of aqueous deficient dry eye. In each patient, the smart plug was inserted in the lower punctum of the right eye which was considered as study group 1 and silicone plug was inserted in the lower punctum of the left eye of the same patient which was considered as study group 2. All patients were subjected to careful history taking and questionnaire for subjective assessment of severity of symptoms. Corneal sensitivity, corneal fluorescein, rose bengal staining, Schirmer's I test, tear film break up time and conjunctival impression cytology were performed pre and 1, 3 and 6mo post plug insertion.A statistically significant improvement in subjective and objective manifestations occurred following treatment with both types of plugs (P<0.01). The thermosensitive plug caused significant overall improvement, decrease in frequency of application of tear substitutes and improvement of conjunctival impression cytology parameters in the inserted side (P<0.01). Canaliculitis was reported in two eyes (4.4%) following punctal occlusion using thermosensitive plug (study group 1). Spontaneous plug loss occurred in 21 eyes (46.6%) in the silicone plug group (study group 2).Improvement of subjective and objective manifestations of aqueous deficient dry eye occurs following punctal plug occlusion. Thermosensitive plug has good patient's compliance with fewer complications and lower rates of loss compared to the silicone plug.

Artificial tears

10.18240/ijo.2016.11.10

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ROLE OF HEAVY METALS BIOACCUMULATION ON SOME PHYSIOLOGICAL AND HISTOPATHOLOGICAL CHANGES IN THE CULTURED OREOCHROMIS NILOTICUS AND MUGIL CEPHALUS AT EL-FAYOUM GOVERNORATE, EGYPT

Egyptian Journal Of Zoology (2016)

K. Zaghloul Azza Mohamed Ahmed Said Samira El-Sayad Ghada Ali

As the world population increase, the demand for high protein foods would gradually rise. Heavy metals are natural trace components of the aquatic environment, but their levels have been increased due to industrial wastes, geochemical structure, agricultural and mining activities. The absorption and accumulation of different pollutants vary among different biological systems. Therefore, the present study aims to high lighten the impact of the bioaccumulation of heavy metals in different organs of fish and the factors affecting their dissemination. It is also concerned with the study of some physiological and biochemical parameters of the two studied fish species and their ability to resist stressors. This is confirmed by histopathological investigation on the diagnosis of fish diseases caused by the heavy metals. Bioaccumulation of heavy metals in fish tissues led to histopathological alterations in liver and kidneys of both fish species collected from the studied fish farms that irrigated with agricultural drainage water (El-Berka and El-Wadi).These alterations didn’t occur in case of Demo fish farm that irrigated with fresh water of Bahr Yousef (branch of the river Nile). Data representing the hematological parameters of both fish species collected from Demo fish farm showed blood picture values within normal ranges. However, there was a highly significant decrease in values of erythrocytes count, hemoglobin content and hematocrit value for both studied fish species collected from the other studied fish farms (El-Berka and El-Wadi). This decrease was accompanied by an increase in mean corpuscular volume as a case of macrocytic anemia in case of Oreochromis niloticus and microcytic anemia in case of Mugil cephalus. The present results revealed that there were highly significant differences in the other blood indices and blood leucocytes of each species individually collected from the different studied fish farms. The results declared highly significant differences in serum glucose, total protein, creatinine, and uric acid concentrations, in addition to ASAT and ALAT activities for each species in the studied fish farms that resemble different aquatic habitats.

Mugil

10.12816/0034716

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