Azza Mohamed Ahmed Said

Ain Shams University

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S. Makki

Texas A&M University at Qatar

J. Millet

Génétique et Immunologie des Maladies Parasitaires

Abdelrahman Gaber Salman

Ain Shams University

Patrice Muret

Université de franche-comté

Maha Nasr

Ain Shams University

Ph. Humbert

Hôpital Saint-Jacques

Samira El-Sayad

Fayoum University

Hanan Hussein Shehata

Ain Shams University

Yaser Abdelmageuid Elzankalony

Ain Shams University

Mohamed Omar Yousif

Ain Shams University

Cooperative Institutions

Ain Shams University

Hôpital Saint-Jacques

Cairo University

Université de franche-comté

Centre Hospitalier Universitaire de Besançon

Ain Shams University Hospital

Heliopolis University

Service de la Santé Publique

Alexandria University

Inserm

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Ultrasound biomicroscopy study of accommodative state in Smartphone abusers

BMC Ophthalmology (2022)

Randa Farouk Kashif Mohammad Rashad Azza Mohamed Ahmed Said Menan A. Rabie Wael Adel Gomaa

Abstract Background Addiction to Smartphone usage has psychological and physical impacts. However, the state of spasm of accommodation is unclear in Smartphone abusers. Methods We performed a cross-sectional study among adults aged 18–35 years between October 2016 and December 2018. Forty participants were Smartphone abusers according to the Smartphone addiction questionnaire, and 40 participants were non users. We measured auto refraction precycloplegia and postcycloplegia at far for all participants to evaluate the state of spasm of accommodation. We assessed the ultrasound biomicroscopy (UBM) parameters including anterior chamber angle (ACA). Results There was a significant difference in the odds of having spasm of accommodation between Smartphone abusers compared to non-users (OR = 6.64, 95% CI = 1.73–25.47; adjusted OR = 14.63, 95% CI = 2.99–71.62). The Smartphone abusers and non-users groups had a superior ACA median of 30.45 ° ± 8.3 ° vs. 26.75 ° ± 6.6 ° ( P = 0.04) precycloplegia at far and 31.70 ° ± 11.8 ° vs. 31.45 ° ± 8.3 ° ( P = 0.15) postcycloplegia at far, respectively, demonstrated by the Mann-Whitney U test. There was significant higher difference in the precycloplegic nasal ACA at far in the Smartphone abusers group than the non-users group (mean precycloplegic nasal ACA difference = 3.57 ° , 95% CI = 0.76 ° - 6.37 ° ), demonstrated by the independent t test. Similarly, there was significant higher difference in the postcycloplegic nasal ACA at far (mean postcycloplegic nasal ACA difference = 4.26 ° , 95% CI = 1.33 ° - 7.19 ° ). Conclusions Smartphone abusers are in a condition of accommodation spasm. As a result, cycloplegic refraction should be done for Smartphone abusers.

Cross-sectional study

10.1186/s12886-022-02557-x

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Citations (3)

Foveal Avascular Zone Evaluation in Patients with Diabetic Retinopathy without Diabetic Macular Edema Using Optical Coherence Tomography Angiography

Research Square (Research Square) (2021)

Mohamed Mahmoud Halfawy Abelrahman Gaber Salman Azza Mohamed Ahmed Said Tarek El Beltagi Marwa A. Karim

Abstract The authors have requested that this preprint be removed from Research Square.

Foveal avascular zone

Diabetic macular edema

10.21203/rs.3.rs-280313/v1

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Citations (1)

Wettability of psoralen powders: influence of bile salts on their contact angles and surface free energy components

Colloids and Surfaces B Biointerfaces (1997)

Azza Mohamed Ahmed Said A. Mavon S. Makki Ph. Humbert J. Millet

Diiodomethane

Sodium Cholate

Heptane

10.1016/s0927-7765(96)01326-4

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Citations (3)

Additional file 1: of Efficacy of Intravitreal injection of 2-Methoxyestradiol in regression of neovascularization of a retinopathy of prematurity rat model

Figshare (2017)

Azza Mohamed Ahmed Said Rania Zaki Rania Salah Eldin Maha Nasr Samar S. Azab

Data.xlsx includes raw data of ROP animal models that were injected inravitreally using two different concentrations of 2-Methoxyestradiol (2-ME) nanoparticles in order to produce regression of neovascularization (NVs) and the data of the control groups. The file includes one data sheet. The sheet includes data of each animal in terms of endothelial cell count on vitreal side, percentage of vascular endothelial growth factor (VEGF) expression and percentage of glial fibrillary acidic protein (GFAP) expression before and after treatment. (XLSX 12 kb)

2-Methoxyestradiol

10.6084/m9.figshare.c.3734212_d1

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Structural changes of the macula and optic nerve head in the remaining eyes after enucleation for retinoblastoma: an optical coherence tomography study

BMC Ophthalmology (2017)

Azza Mohamed Ahmed Said Ahmed M. El-Bayomi Ashraf Abdelsalam Kandeel Shaat

To describe objectively the possible structural changes of the macula and optic nerve head in the free eyes of unilateral cured retinoblastoma patients and, also after enucleation using spectral domain optical coherence tomography.A cross sectional study involving 60 patients subdivided into three groups; 15 unilateral RB patients in whom enucleation was indicated as a sole treatment performed earlier in life [(study group (I)], 15 unilateral RB patients who had completely regressed disease with a preserved eye [(study group (II)] and 30 age and sex matched healthy controls. The remaining and free eyes in study groups and right eyes of control group had full ophthalmological examination, static automated perimetry and optical coherence tomography of the macula and optic nerve head.In study group (II); a significant thinning of total macula, central fovea, ganglion cell layer (GCL), ganglion cell complex (GCC), and some sectors of outer nuclear layer (P- values ≤0.05) was found with no significant difference in peripapillary nerve fiber layer (pRNFL) thickness and optic nerve head parameters compared to the control group and the study group (I). A significantly thickened total macula, GCL, GCC, and pRNFL in study group (I) compared to study group (II). Thickened pRNFL was significantly correlated to standard automated perimetry pattern deviations. No significant difference was found between study group (I) and control group.Retinoblastoma eyes characterized by thinning of central fovea, GCL, GCC compared to the control group. After unilateral enucleation, increased GCC and pRNFL thicknesses were detected compared to retinoblastoma group.

Retinoblastoma

Eye Enucleation

10.1186/s12886-017-0650-9

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DETERMINATION OF SOME PESTICIDE RESIDUES ON SOME OILY CROPS.

Journal of Plant Protection and Pathology /Journal of Plant Protection and Pathology (2008)

Yasmin Ghazy O. Bayomi F. Shaheen Azza Mohamed Ahmed Said

The present study was carried out to investigate the toxic effect of some pesticides (Lambda-cyhalothrine, methomyl, Carbofuran, Chloropyrifos and Mancozeb) against cotton leaf worm Spodoptera Littoralis.Different samples of peanut, linseed and sunflower seeds were collected, extracted, cleaned up, to use in different studies (toxicity analytical and determination joint action effect of oil peanut extracted with pesticides against S. Littoralis.The pesticides residues mixed with oil extracted, were determined using biochemical's parameters (Acetyl cholinesterase activity).Thin-layer chromatography was used to separate the tested pesticides from each compound.RF values for the tested compounds were recorded alone and in their mixtures with non treated oils.Pesticides residues extracted from the treated samples of peanut, linseed and sunflower seeds oil were determined after studying their effects on Acetyl cholinesterase activities.Results showed that Chloropyrifos insecticide was the most potent compound followed by Lambda-cyhalothrin, Methomyl and Carbofurn.Mancozeb and oil peanut have no toxic effect on S. Littoralis.The joint action effects resulting form mixing oil peanut with each of the tested compounds are shown that synergism was noticed with oil peanut in combination with Methomyl, Chloropyrifos and Lambda respectively.

10.21608/jppp.2008.217960

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In vitro stabilization and in vivo improvement of ocular pharmacokinetics of the multi-therapeutic agent baicalin: Delineating the most suitable vesicular systems

International Journal of Pharmaceutics (2018)

Orchid Ashraf Maha Nasr Marianne Nebsen Azza Mohamed Ahmed Said Omaima A. Sammour

Baicalin

Zeta potential

10.1016/j.ijpharm.2018.01.041

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Citations (60)

Percutaneous absorption of three psoralens commonly used in therapy: Effect of skin occlusion (in vitro study)

International Journal of Pharmaceutics (1996)

S. Makki Patrice Muret Azza Mohamed Ahmed Said P. Bassignot P Humbert

Lipophilicity

Human serum albumin

10.1016/0378-5173(95)04451-5

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Citations (16)

Efficacy of Intravitreal injection of 2-Methoxyestradiol in regression of neovascularization of a retinopathy of prematurity rat model

BMC Ophthalmology (2017)

Azza Mohamed Ahmed Said Rania Gamal Eldin Zaki Rania A. Salah El-Din Maha Nasr Samar S. Azab

Retinopathy of prematurity (ROP) is one of the targets for early detection and treatment to prevent childhood blindness in world health organization programs. The purpose of study was to evaluate the efficacy of intravitreal injection of 2-Methoxyestradiol (2-ME) nanoemulsion in regressing neovascularization of a ROP rat model. A prospective comparative case - control animal study conducted on 56 eyes of 28 healthy new born Sprague Dawley male albino rat. ROP was induced in 21 rats then two concentrations of 2-ME nanoparticles were injected in right eyes of 14 rats (low dose; study group I, high dose; study group II). A blank nanoemulsion was injected in the right eyes of seven rats (control positive group I). No injections performed in contralateral left eyes (control positive group II). Seven rats (14 eyes) were kept in room air (control negative group). On postnatal day 17, eyeballs were enucleated. Histological structure of the retina was examined using Hematoxylin and eosin staining. Vascular endothelial growth factor (VEGF) and glial fibrillary acidic protein (GFAP) expressions were detected by immunohistochemical studies. Intravitreal injection of 2-ME (in the two concentrations) caused marked regression of the new vascular tufts on the vitreal side with normal organization and thickness of the retina especially in study group II, which also show negative VEGF immunoreaction. Positive GFAP expression was detected in the control positive groups and study group (I). Intravitreal injection of 2-Methoxyestradiol nanoemulsion is a promising effective method in reduction of neovascularization of a ROP rat model.

2-Methoxyestradiol

10.1186/s12886-017-0433-3

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Citations (13)

Immunohistochemical expression of CD117 and vascular endothelial growth factor in retinoblastoma: possible targets of new therapies.

PubMed (2014)

Nermeen S Youssef Azza Mohamed Ahmed Said

CD117 (C-kit) is thought to play an important role in tumourigenesis. There are limited data in the literature concerning C-kit expression in retinoblastoma. To date, no immunohistochemical studies have been performed to assess the possible association of C-kit with vascular endothelial growth factor (VEGF) in retinoblastoma. This study was designed to investigate C-kit and VEGF immunoexpression in retinoblastoma, their relationship with prognostic parameters as well as the correlation between them. A prospective immunohistochemical study was conducted on 56 retinoblastoma cases. Patients who had received preoperative chemotherapy were excluded. Positive C-kit and VEGF immunoreactivity was observed in 48.2% and 76.8% of retinoblastoma cases respectively. No C-kit immunostaining was seen in the adjacent uninvolved retina. However, VEGF expression was detected within its vasculature. Retinoblastomas with combined pattern of tumour growth revealed a highly significant positive C-kit expression (P = 0.002) compared to cases with endophytic or exophytic growths. Also, positive C-kit expression was statistically higher in cases with optic nerve invasion (P = 0.001) and choroidal invasion (P ≤ 0.01) compared to negative cases. A highly significant positive VEGF expression was detected in cases with optic nerve invasion (P = 0.013) compared to negative cases. Moreover, a highly significant positive correlation was detected between C-kit and VEGF expression (P = 0.006). C-kit is a feature of more aggressive retinoblastomas, with increased expression in tumours spreading beyond the retina. Moreover, VEGF is vastly expressed in retinoblastoma and is associated with optic nerve invasion. Both C-kit and VEGF may represent potential therapeutic targets for retinoblastomas.

Retinoblastoma

CD117

Immunostaining

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Citations (17)