Angewandte Chemie International Edition is aj ournalo ft he Gesellschaft Deutscher Chemiker (GDCh), the largest chemistryrelated scientific society in continental Europe.Information on the various activities and services of the GDCh, for example, cheaper subscription to Angewandte Chemie International Edition,aswell as applications for membership can be found at www.gdch.deor can be requested from GDCh, Postfach 900440, D-60444 Frankfurt am Main, Germany.…of[3]catenane was induced by fitting the puzzle pieces.Intheir Research Article (202217002), JunT erao et al. report am ethod for ligand-controlled structural switching of [3]catenane,w hich was realized by the complexation of metal ions on [3]catenane with added complementarily fitted organic ligands,like pieces in a jigsaw puzzle.T he high tailorability of organic ligands offers multiple pieces with various sizes and numbers of coordination sites,enabling multistate structural switching of [3]catenane.Carboranes B9-functionalized carboranylphosphines with bulky electron-donating substituents display an extremely electron-releasing character,asr eported by Evamarie Hey-Hawkins et al. in their Research Article (e202218648).Thec ompounds exert ahigh steric demand, which allows the mesityl derivatives to form stabilized phosphoniumyl radical cations.Batteries In their Research Article (e202218745), Haiyan Zhang, Chunyi Zhi, Haiming Lv et al. report acovalent organic framework anode for aqueous batteries with acid-alkaline co-tolerance,long cycle life,and high rate performance.Enzyme Catalysis An enzymatic electrocatalytic system for the simultaneous conversion of CO 2 and NH 3 for glycine synthesis is reported by Zhiguang Zhu et al. in their Research Article (e202218387).
…of[3]catenane was induced by fitting the puzzle pieces.Intheir Research Article (202217002), JunT erao et al. report amethod for ligand-controlled structural switching of [3]catenane,w hich was realized by the complexation of metal ions on [3]catenane with added complementarily fitted organic ligands,like pieces in a jigsaw puzzle.T he high tailorability of organic ligands offers multiple pieces with various sizes and numbers of coordination sites,enabling multistate structural switching of [3]catenane.Organic Electronics Spiroborate-based host materials with high triplet energies and ambipolar charge-transport properties are reported by Takuji Hatakeyama et al. in their Communication (e202217512).Carboranes B9-functionalized carboranylphosphines with bulky electron-donating substituents display an extremely electron-releasing character,asr eported by Evamarie Hey-Hawkins et al. in their Research Article (e202218648).Thec ompounds exert ahigh steric demand, which allows the mesityl derivatives to form stabilized phosphoniumyl radical cations.Batteries In their Research Article (e202218745), Haiyan Zhang, Chunyi Zhi, Haiming Lv et al. report acovalent organic framework anode for aqueous batteries with acid-alkaline co-tolerance,long cycle life,and high rate performance.
The present study was conducted to assess the applicability of liquid-based cytology (LBC) using an innovative oral brush, Orcellex. Fifty healthy volunteers were recruited. From each subject, four samples were collected using "Orcellex" from apparently normal oral mucosal sites. A plastic spatula was also used to obtain an additional sample. Data on the tolerability and acceptability of the Orcellex were collected from the subjects, together with assessments of the adequacy of LBC slide preparations for cellularity, preparation quality, and the types of cells observed. The Orcellex brush was well accepted by the volunteers, who reported relatively little pain. Orcellex brush LBC preparations were of good quality in terms of cell morphology and staining, with a clean background. Only two smears (2/200; 1%) were found to be inadequate due to low cellularity. All of the plastic spatula LBC preparations were inadequate. Representative cells from all layers of the different oral epithelia examined were documented. Oral liquid-based cytology using the Orcellex brush may have considerable potential for early detection of oral cancer and precancer.
Patients with partially destroyed fingernails tend to hide them, and such patients often do not find help because fingernails are considered of little functional value. To improve the aesthetic appearance of such nails, a simple excision of the destroyed nail matrix can stimulate the growth of the residual healthy matrix and regenerate the nail. Prerequisite is a healthy nail residue of at least the lunula. An excision of an en bloc, crescent-shaped, full-thickness scar, 5 mm at its greatest width and extending from one lateral nail fold to the other, increases the length of the nail plate. Together with the matrix, the nail will grow about 4 mm distally. A second crescent-shaped excision 1 to 2 months later will further lengthen the nail until it has gained full length. Normal nail growth was achieved in 11 patients who had partially scarred nail beds after mycosis or trauma. (Plast. Reconstr. Surg. 111: 167, 2003.)
The clinical course of patients with cystic fibrosis (CF) with functionally similar mutations in the CF transmembrane conductance regulator gene is variable and must therefore relate to secondary genetic and environmental factors. We examined the hypothesis that polymorphisms of certain inflammatory mediator and regulatory genes affect clinical outcome by influencing the degree of end-organ damage. By studying the possible association between clinical outcome and angiotensin I-converting enzyme (ACE) and cytokine genotypes by amplification refractory mutation system-polymerase chain reaction, using stored DNA from 261 white patients with CF, we found that ultrasound features of cirrhosis occurred more frequently in patients with the high-producer (DD) rather than the low-producer (II) ACE genotype (odds ratio [95% confidence interval], 3.7 [1.2 to 12]). Moreover, significant pulmonary dysfunction (age at which FEV1 < 50%) was associated with the high-producer ACE genotype (2.3 [1.2 to 4.5]) and transforming growth factor-beta1 genotype (2.6 [1.0 to 6.8]) as well as with age at first colonization with Pseudomonas aeruginosa (9.1 [1.1 to 72]). We conclude that the high-producer ACE genotype predicts patients with CF who have an increased chance of developing portal hypertension; and high-producer ACE and TGF-beta1 genotypes are secondary genetic factors contributing to pulmonary dysfunction in these patients.
A particular haplotype defined by probes XV2c, KM19, and CS.7 at the D7S23 locus was found on 90% of chromosomes which carry cystic fibrosis (CF), but on only 11% of normal chromosomes in a UK sample of CF carriers. We show how such data can be used to calculate carrier risks for people with and without a family history of CF, and give examples of clinical applications. For parents or sibs of dead CF patients, phase and genotypes can often be assigned with only 1 to 2% error. However, this method is not suitable for prenatal testing where there is no history of CF; for couples with no family history, no fetus can be shown to be at more than 2% risk of being affected.
The genetic etiology of intellectual disability remains elusive in almost half of all affected individuals. Within the Solve-RD consortium, systematic re-analysis of whole exome sequencing (WES) data from unresolved cases with (syndromic) intellectual disability (n = 1,472 probands) was performed. This re-analysis included variant calling of mitochondrial DNA (mtDNA) variants, although mtDNA is not specifically targeted in WES. We identified a functionally relevant mtDNA variant in MT-TL1 (NC_012920.1:m.3291T > C; NC_012920.1:n.62T > C), at a heteroplasmy level of 22% in whole blood, in a 23-year-old male with severe intellectual disability, epilepsy, episodic headaches with emesis, spastic tetraparesis, brain abnormalities, and feeding difficulties. Targeted validation in blood and urine supported pathogenicity, with heteroplasmy levels of 23% and 58% in index, and 4% and 17% in mother, respectively. Interestingly, not all phenotypic features observed in the index have been previously linked to this MT-TL1 variant, suggesting either broadening of the m.3291T > C-associated phenotype, or presence of a co-occurring disorder. Hence, our case highlights the importance of underappreciated mtDNA variants identifiable from WES data, especially for cases with atypical mitochondrial phenotypes and their relatives in the maternal line.
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