Abstract Drug‐resistant bacterial infection impairs tissue regeneration and is a challenging clinical problem. Metal–organic frameworks (MOFs)‐based photodynamic therapy (PDT) opens up a new era for antibiotic‐free infection treatment. However, the MOF‐based PDT normally encounters limited photon absorbance under visible light and notorious recombination of photogenerated holes and electrons, which significantly impede their applications. Herein, a MOFs‐based nanosystem (AgNPs@MOFs) with enhanced visible light response and charge carrier separation is developed by modifying MOFs with silver nanoparticles (AgNPs) to improve PDT efficiency. The AgNPs@MOFs with enhanced photodynamic performance under visible light irradiation mainly disrupt bacteria translation process and the metabolism of purine and pyrimidine. In addition, the introduction of AgNPs endows nanosystems with chemotherapy ability, which causes destructive effect on bacterial cell membrane, including membrane ATPase protein and fatty acids. AgNPs@MOFs show excellent synergistic drug‐resistant bacterial killing efficiency through multiple mechanisms, which further restrain bacterial resistance. In addition, biocompatible AgNPs@MOFs pose potential tissue regeneration ability in both Methicillin–resistant Staphylococcus aureus (MRSA)‐related soft and hard tissue infection. Overall, this study provides a promising perspective in the exploration of AgNPs@MOFs as nano antibacterial medicine against drug‐resistant bacteria for infected tissue regeneration in the future.
Gold nanoparticles display the regulatory property of pro-osteogenesis, anti-adipogenesis and anti-osteoclasis, thus promoting bone repair under hyperlipidemia.
Recent advancements in radiative cooling technologies have highlighted their potential as sustainable and environmentally friendly cooling solutions. However, while this method offers significant energy savings during hot seasons, it may incur energy losses (overcooling leads to a waste of cooling energy) in colder conditions. The current solution has the problems of a complex process or easy leakage of materials. To address this challenge, we synthesized a SiO2 nanohybrid (a SiO2 nanoparticle with elongated polymer chains grafted onto its surface), which modifies the thermoresponsive behavior of radiative cooling composites. Upon incorporation of these nanohybrids into the radiative cooling matrix, it will display significant morphological changes in response to temperature variations, leading to changes in the emissivity of the resulting composite film. What's more, the reflectivity of the composite film was enhanced from 57.26 to 89.37%, increasing the cooling performance by 4 °C in hot weather. Results confirmed that the composite film maintained structural integrity without leakage, demonstrating a robust durability. Overall, the synthesized SiO2 nanohybrids in this work will offer valuable insights for advancing radiative cooling applications.
Designing bone adhesives with adhesiveness, antideformation, biocompatibility, and biofunctional effects has great practical significance for bone defect reconstructive treatment, especially for bone graft repair surgery. Here, we designed zeolitic imidazolate framework-8 nanoparticle (ZIF-8 NP)-modified catechol–chitosan (CA-CS) multifunctional hydrogels (CA-CS/Z) to stabilize the bone graft environment, ensure blood supply, promote osteogenic differentiation, and accelerate bone reconstruction. Characterizations confirmed the successful synthesis of CA-CS/Z hydrogels. Hydrogels exhibited advanced rheological properties, reliable mechanical strength, and excellent adhesion for clinical applications. Based on excellent biocompatibility, it could enhance paracrine of the vascular endothelial growth factor (VEGF) in rat bone marrow mesenchymal stem cells (rBMSCs) to ensure blood supply reconstruction in bone defect areas. Furthermore, the ZIF-8 NPs released from the hydrogels could also up-regulate the production and secretion of alkaline phosphatase, collagen 1, and osteocalcin, promoting the osteogenic differentiation of rBMSCs. In addition, the antibacterial properties of CA-CS/Z could also be observed. In vivo experiments further provided a powerful proof that CA-CS/Z promoted vascularized osteogenesis in wound areas by stabilizing bone graft materials and greatly accelerated the speed and healing of bone reconstruction. These results indicate the promising potential of CA-CS/Z hydrogels with promoting implantation stability, angiogenesis, and osteogenesis for bone regeneration applications.
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