Masao Sato

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Effects of Docosahexaenoic and Eicosapentaenoic Acid on Lipid Metabolism, Eicosanoid Production, Platelet Aggregation and Atherosclerosis in Hypercholesterolemic Rats

Bioscience Biotechnology and Biochemistry (1999)

Yosef Adan Kenichi Shibata Masao Sato Ikuo Ikeda Katsumi Imaizumi

Exogenously hypercholesterolemic (ExHC) rats were fed on an atherogenic diet supplemented with 1% each of either ethyl ester docosahexaenoic acid [EE-DHA, 22:6(n-3)], ethyl ester eicosapentaenoic acid [EE-EPA, 20:5(n-3)] or safflower oil (SO) for 6 months. The rats fed on the diets containing EE-EPA or EE-DHA, compared with those fed on SO, had lower serum cholesterol and triacylglycerol levels, less aggregation of platelets and slower progress of intimal thickening in the ascending aorta. Relative to the SO-fed rats, both of the (n-3) fatty acid-fed rats had a significantly reduced proportion of arachidonic acid in the platelet and aortic phospholipids, and lower production of thromboxane A2 by platelets and of prostacyclin by the aorta. These results suggest that EPA and DHA are similarly involved in preventing atherosclerosis development by reducing hypercholesterolemia and modifying the platelet functions.

10.1271/bbb.63.111

Cite

Citations (43)

Effects of xylooligosaccharides on blood glucose, serum and liver lipids and cecum short-chain fatty acids in diabetic rats.

Agricultural and Biological Chemistry (1991)

Katsumi Imaizumi Yoriko Nakatsu Masao Sato Sedarnawati Yasni Michihiro Sugano

The effect of supplementing xylooligosaccharides (XO) to purified diets on growth performance and several metabolic parameters was examined in streptozotocin-induced diabetic rats. The dietary XO improved growth retardation, hyperphagia, polydipsia, elevation of serum glucose, triglyceride and cholesterol, reduction of liver triglyceride, and fatty acid composition (reduction of the desaturation index) of liver phosphatidylcholine. In addition, the XO diet yielded an acidic environment in the cecum by increasing the pool size of acetic acid. Thus, XO, which is half as sweet as sucrose, can be applicable to foods as a sweetener that is capable of improving diabetic symptoms.

Cecum

10.1271/bbb1961.55.199

Cite

Citations (83)

Serum pyridoxal concentrations and depressive symptoms among Japanese adults: results from a prospective study

European Journal of Clinical Nutrition (2013)

Akiko Nanri Ngoc Minh Pham Kayo Kurotani Ayami Kume Keisuke Kuwahara

Depression

Cross-sectional study

10.1038/ejcn.2013.115

Cite

Citations (6)

L-kynurenine concentration in the serum and synovial fluid of rheumatoid arthritis patients.

臨床リウマチ (2000)

Masao Sato Hirohisa Koishi Ryuki Shinohe Kuniaki Saito Masao Takemura

Source

Cite

Citations (0)

Ethanol‐extracted soy protein isolate results in elevation of serum cholesterol in exogenously hypercholesterolemic rats

Lipids (1999)

Weihua Ni Susumu Yoshida Yasuyuki Tsuda Koji Nagao Masao Sato

Abstract Soy protein preparations were reported to have hypocholesterolemic actions in experimental animals and humans, while the active components and the mechanism by which this occurs are not clarified yet. The objective of this study is to address these issues by using exogenously hypercholesterolemic rats which are susceptible to dietary cholesterol. Two groups of five rats (male, 12‐wk‐old) were fed on AIN 93G‐based diet with soy protein isolate (SPI) or ethanol‐extracted SPI (EE‐SPI) for 2 wk. EE‐SPI was prepared by ethanol extraction to remove isoflavones and other components. Concentrations of serum and liver total cholesterol were lower in rats fed SPI than in those fed EE‐SPI. The abundances of mRNA for 7α‐hydroxylase and low density lipoprotein receptor in the liver were lower in EE‐SPI group than those in SPI group. These results suggest that the ethanol extract from SPI has a factor(s) to alleviate hypercholesterolemia by increasing the removal of cholesterol from serum through the receptor pathway and then from liver through enhancement of bile acid synthesis.

Lipidology

Low-density lipoprotein

10.1007/s11745-999-0417-1

Cite

Citations (27)

Phytosterol Oxidation Products Are Absorbed in the Intestinal Lymphatics in Rats but Do Not Accelerate Atherosclerosis in Apolipoprotein E–Deficient Mice

Journal of Nutrition (2004)

Hiroko Tomoyori Y. Kawata Tomoko Higuchi Ikuyo Ichi Hiroyoshi Sato

Phytosterol

10.1093/jn/134.7.1690

Cite

Citations (100)

Learning behaviour and cerebral protein kinase C, antioxidant status, lipid composition in senescence-accelerated mouse: influence of a phosphatidylcholine–vitamin B₁₂diet

British Journal Of Nutrition (2001)

Mei-Chu Hung Koji Shibasaki Riki Yoshida Masao Sato Katsumi Imaizumi

Our objective was to determine whether dietary supplementation with phosphatidylcholine (PC) plus vitamin B 12 could afford beneficial effects on biochemical and biophysical events in the brain of senescence-accelerated mouse (SAM) substrain SAMP8. We measured learning behaviour, hippocampal protein kinase C (PKC) activity, cerebral antioxidant status, phospholipid composition and fatty acid composition in 6-month-old SAMP8 and in age-matched controls (SAM substrain SAMR1). In comparison with SAMR1, SAMP8 showed a significant elevation in total grading score of senescence (P<0·05) and a significant decline in acquisition (P<0·05). SAMP8 had a lower hippocampal PKC activity and cerebral PKC-β mRNA abundance than SAMR1. SAMP8 had increased cerebral lipid peroxide levels and proportion of sphingomyelin, and a lower proportion of 20 : 4 n -6 and 22 : 6 n -3 in cerebral phosphtidylethanolamine than SAMR1. SAMP8 fed the PC combined with vitamin B 12 diet had an increased PKC activity and a higher proportion of 22 : 6 n -3 than SAMP8 fed the control diet. These results indicate the potential benefit of PC combined with vitamin B 12 as a dietary supplement.

Senescence

Lipid peroxide

10.1079/bjn2001391

Cite

Citations (47)

Dietary kakrol (Momordica dioica Roxb.) flesh inhibits triacylglycerol absorption and lowers the risk for development of fatty liver in rats

Experimental Biology and Medicine (2011)

Masao Sato Takatoshi Ueda Kazuko Nagata Sawako Shiratake Hiroko Tomoyori

Kakrol (Momordica dioica Roxb.) is a cucurbitaceous vegetable native to India and Bangladesh. Bitter gourd (Momordica charantia Linn.), a species related to kakrol, has been shown to have pharmacological properties including antidiabetic and antisteatotic effects. In this study, we investigated the effect of dietary kakrol on lipid metabolism in rats. Sprague-Dawley rats were fed AIN-76 formula diets containing 3% freeze-dried powders of whole kakrol or bitter gourd for two weeks. Results showed significantly lowered liver cholesterol and triacylglycerol levels in rats fed on both diets. Fecal lipid excretion increased in rats fed the kakrol diet, and lymphatic transport of triacylglycerol and phospholipids decreased in rats fed the kakrol diet after permanent lymph cannulation. Furthermore, n-butanol extract from kakrol caused a significant concentration-dependent decrease in the pancreatic lipase activity in vitro. These results indicate that the mechanisms of action on lipid metabolism in kakrol and bitter gourd are different and that dietary kakrol reduces liver lipids by inhibiting lipid absorption.

Flesh

10.1258/ebm.2011.011037

Cite

Citations (12)

Studies on the metabolic fate of azuletil sodium. (III): Absorption, distribution, metabolism and excretion after repeated oral administration to rats, transfer into the fetus and milk, and induction of the liver microsomal drug-metabolizing enzymes by the repeated oral administration to rats.

Drug Metabolism and Pharmacokinetics (1990)

Masao Sato Hiroaki SUZAKA Akira Tomiyama Hiroshi Miyazaki

The absorption, distribution and excretion of 14C-KT1-32 were studied after repeated oral administration to male rats. Transfer of radioactivities into the fetus and milk after oral administration of 14C-KT1-32 to pregnant or lactating rats were studied. The induction of the hepatic drug-metabolizing enzymes was studied after repeated oral administration of KT1-32 to male rats.1. On day 13 and 18 of gestation, the autoradiography revealed that the radioactivity in the fetus was lower than that in the maternal blood. On day18 of gestation, the radioactivities in the fetal liver and kidney were lower than that in the maternal plasma.2. The radioactivity in the milk was lower than that in the maternal blood within 8hr after administration. The disappearance of radioactivity from the milk was slower than that from the blood.3. After repeated administration, the radioactivity in the blood reached the steady state within 24hr following the 1st administration. Cumulative excretion ratios in urine and feces reached a constant value after the 3rd administration. The radioactivities in the tissues at 24 hr reached the steady state after the 7th administration, but the disappearance of radioactivity from the tissues after the 21st administration was quite similar to that after single administartion.4. In the plasma and urine after the 21st administration, the Ml, M2 metabolites and the intact drug were detected as major components and M4, M3, M5 and M6 were found in the urine as the minor ones.5. After repeated oral administration of KT1-32 to male rats, there was no induction of the hepatic drug-metabolizing enzymes.

10.2133/dmpk.5.249

Cite

Citations (0)

A Data Representing Method for Flexible Layout Systems.

The Journal of Japan Institute for Interconnecting and Packaging Electronic Circuits (1996)

Yuichi Hasegawa Shuichi Shibata Masao Sato Tatsuo Ohtsuki

MCM (Multi Chip Module) やプリント配線板のレイアウト設計において従来から用いられてきた配線手法としては, 配線の絶対位置であるジオメトリによって管理する手法が多い。配線径路をジオメトリで管理する手法では, 既配線が障害物と同様に固定されて扱われるために, 要求される微妙な特性を配線に反映させることが難しい。これに対し, 配線の相対位置であるトポロジーによって管理する手法がある。本稿では実用的かつ柔軟性の高いトポロジー表現 (スケッチ表現) について検討し, その実現法としてスケッチ表現のためのデータ構造を明らかにする。また, その応用例としてスケッチ表現に基づいてレイアウトの調整ができるような多層レイアウトシステムを提案する。スケッチレイアウトシステムは三角形分割を基本構造とし, 高速な配線可能性検証, レイアウトの動的更新を可能とするものである。

10.5104/jiep1995.11.408

Cite

Citations (0)