F Vilardell

Universitat de Lleida

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Gabriel Capellá

Institut Català d'Oncologia

Carlos Guarner

Hospital de Sant Pau

Blanca Alvarez-Moya

Vita-Salute San Raffaele University

Neus Bota-Rabassedas

The University of Texas MD Anderson Cancer Center

Neus Agell

Consorci Institut D'Investigacions Biomediques August Pi I Sunyer

Montserrat Jaumot

Departament de Salut

Carles Barceló

Universitat Oberta de Catalunya

Noelia Paco

Servei de Salut de les Illes Balears

Mireia Morell

Universidad Rovira i Virgili

Sergio Sáinz

Hospital de Sant Pau

Cooperative Institutions

Hospital Universitari Arnau de Vilanova

139

Universitat Autònoma de Barcelona

112

Biomedical Research Institute of Lleida

101

Universitat de Lleida

Hospital de Sant Pau

Universitat de Barcelona

Instituto de Salud Carlos III

Institut Català d'Oncologia

Institut d'Investigació Biomédica de Bellvitge

Hospital Arnau de Vilanova

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Human Menstrual Blood-Derived Mesenchymal Stem Cells as Potential Cell Carriers for Oncolytic Adenovirus

Stem Cells International (2017)

Rafael Moreno Luis A. Rojas F Vilardell Vanessa Cervera Soriano Javier García‐Castro

Antitumor efficacy of systemically administered oncolytic adenoviruses (OAdv) is limited due to diverse factors such as liver sequestration, neutralizing interactions in blood, elimination by the immune system, and physical barriers in tumors. It is therefore of clinical relevance to improve OAdv bioavailability and tumor delivery. Among the variety of tumor-targeting strategies, the use of stem cells and specifically bone marrow-derived mesenchymal stem cells (BM-MSCs) is of particular interest due to their tumor tropism and immunomodulatory properties. Nonetheless, the invasive methods to obtain these cells, the low number of MSCs present in the bone marrow, and their restricted in vitro expansion represent major obstacles for their use in cancer treatments, pointing out the necessity to identify an alternative source of MSCs. Here, we have evaluated the use of menstrual blood-derived mesenchymal stem cells (MenSCs) as cell carriers for regional delivery of an OAdv in the tumor. Our results indicate that MenSCs can be isolated without invasive methods, they have an increased proliferation rate compared to BM-MSCs, and they can be efficiently infected with different serotype 5-based capsid-modified adenoviruses, leading to viral replication and release. In addition, our in vivo studies confirmed the tumor-homing properties of MenSCs after regional administration.

Homing (biology)

Oncolytic adenovirus

10.1155/2017/3615729

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Citations (31)

Lethal pseudomembranous colitis in an immunocompetent patient.

PubMed (2015)

Cristina Gas-Ruiz S. Ros-López F Vilardell M. Carmen Mias Carballal Rafael Villalobos-Mori

Pseudomembranous colitis

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Citations (2)

[Autoimmunity in ulcerous colitis].

PubMed (1965)

F Vilardell

Source

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Citations (0)

Level of HER2 Gene Amplification Predicts Response and Overall Survival in HER2-Positive Advanced Gastric Cancer Treated With Trastuzumab

Journal of Clinical Oncology (2013)

Carlos Gómez-Martín Carlos Plaza Roberto Pazo-Cid Antonieta Salud Francesc Pons

Previous studies have highlighted the importance of an appropriate human epidermal growth factor receptor 2 (HER2) evaluation for the proper identification of patients eligible for treatment with anti-HER2 targeted therapies. Today, the relationship remains unclear between the level of HER2 amplification and the outcome of HER2-positive gastric cancer treated with first-line chemotherapy with trastuzumab. The aim of this study was to determine whether the level of HER2 gene amplification determined by the HER2/CEP17 ratio and HER2 gene copy number could significantly predict some benefit in overall survival and response to therapy in advanced gastric cancer treated with trastuzumab-based chemotherapy.Ninety patients with metastatic gastric cancer treated with first-line trastuzumab-based chemotherapy were studied. The optimal cutoff values for HER2/CEP17 ratio and HER2 gene copy number (GCN) for discriminating positive results in terms of response and prolonged survival were determined using receiver operating characteristic curves analyses.In this study, a median HER2/CEP17 ratio of 6.11 (95% CI, 2.27 to 21.90) and a median HER2 gene copy number of 11.90 (95% CI, 3.30 to 43.80) were found. A mean HER2/CEP17 ratio of 4.7 was identified as the optimal cutoff value discriminating sensitive and refractory patients (P = .005). Similarly, the optimal cutoff for predicting survival longer than 12 months was 4.45 (P = .005), and for survival longer than 16 months was 5.15 (P = .004). For HER2 GCN, the optimal cutoff values were 9.4, 10.0, and 9.5, respectively (P = .02).The level of HER2 gene amplification significantly predicts sensitivity to therapy and overall survival in advanced gastric cancer treated with trastuzumab-based chemotherapy.

Cut-off

10.1200/jco.2013.48.9070

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Citations (182)

The Role of OMGE In Education and Training: Working Group 5

Scandinavian Journal of Gastroenterology (1989)

F Vilardell C. Tasman Jones Karen Henley Basanta Tandon A Gabryelewicz

OMGE is a federation of national gastroenterology societies which may enjoy a different overall status in each different country. No role for OMGE in the graduate teaching of gastroenterology is envisaged. OMGE should confine itself to postgraduate teaching and education, since graduate education may vary considerably in different countries in accordance with epidemiology, local needs, and primary and secondary care organization. The OMGE education survey conducted by Myren et al. (1) clearly shows that there are wide differences in the size and the estimated needs of the speciality, the formal requirements for specialization, and, obviously, the training and educational programs implemented in each nation. The ultimate goal of OMGE, which is to provide guidelines and minimal recommendations for an optimal organization of education and training, is still distant; however, the following recommendations derived from the OMGE educational survey may be pertinent to the future role of OMGE.

10.3109/00365528909091054

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Gastric emptying of two radiolabelled antacids.

Gut (1991)

Joan Monés Ignasi Carrió M. Roca Montserrat Estorch R Calabuig

The rate of gastric emptying of two antacids, magaldrate and Maalox, was investigated using scintigraphy. Successful labelling of the antacids was carried out with 99mTc. The stability of the 99mTc-labelled antacids was satisfactory and there was no difference in antacid capacity between the labelled and unlabelled antacids. The studies were carried out on 15 healthy male volunteers. After an eight hour fast each subject ingested a standardised meal of 95.7 MJ (400 kcal). One hour later 10 ml of one of the two antacids previously labelled with 99mTc was administered. Serial detection by anterior and posterior projection of the amount of antacid retained in the stomach was performed to determine gastric emptying of antacid. One week later the study was repeated under the same conditions with the other antacid also labelled with 99mTc. The mean (SD) percentages of antacid retained in the stomach fit a linear model with a t1/2 of 86.6 (15.3) minutes for magaldrate and 52.3 (5.2) minutes for Maalox (p less than 0.01). When the mean percentages of retention at six time intervals were compared for both antacids, it was found that Maalox emptied much faster (p less than 0.01 at 15 and 30 minutes, p less than 0.02 at 45, 60, 75, and 90 minutes).

Antacid

Volunteer

10.1136/gut.32.2.147

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Citations (9)

Bacterial infections in cirrhotic patients submitted to selective intestinal decontamination with norfloxacin

Journal of Hepatology (1990)

Andres Tomas Germán Soriano Carlos Guarner Montserrat Teixidó C. del Mar Verde Méndez

Human decontamination

10.1016/0168-8278(90)91796-y

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