Extensive Nasal Plaque: An Unusual Presentation of IgG4-related Disease
Camila CortésSilvia BielsaJ M Culebras FernándezF VilardellBlanca González‐FarréJosep Manel Casanova
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IgG4-Related Disease
Presentation (obstetrics)
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Seperti pada dewasa, teknik regional anestesi pada pediatrik kini makin popular digunakan oleh ahli anestesikarena keuntungannya. Namun demikian selalu ada risiko dan kemungkinan timbulnya komplikasi dari setiap tindakan yang dilakukan, termasuk tindakan anestesi regional pada pediatrik. Insidensi komplikasi anestesi regional pada pediatrik tidak banyak, dan kalaupun terjadi komplikasi adalah minor. Komplikasi bisa diakibatkan dari identifikasi ruang saraf, alat, obat, teknis tindakan anestesi regionalnya dan komplikasi lainnya.Walaupun tidak banyak kejadian komplikasi regional anestesi yang dilaporkan pada pediatrik, dan bukanlah komplikasi yang fatal, teknik regional anestesi pada pediatrik harus dilakukan dengan lebih hatihati, pertimbangan risiko dan keuntungannya untuk menghindari terjadinya komplikasi, terlebih karena kebanyakan komplikasi dapat dihindari dengan mempelajari teknik yang benar, menggunakan peralatan yang sesuai, dan sangat menerapkan prinsip keamanan pada pasien dengan baik.
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Genentech is partnering with the German cancer company Affimed to develop immunotherapies for multiple kinds of solid and blood cancers. Affimed is developing therapies that engage natural killer cells of the innate immune system to help direct them to attack cancer cells. Genentech will pay Affimed $96 million up front and up to $5 billion more in potential payments.
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An inflammatory pseudotumor is a benign mass comprised of myofibroblasts and fibrous tissue with a marked inflammatory infiltrate composed of predominantly plasma cells. Immunoglobulin G4-related disease (IgG4-RD) is an increasingly recognized fibro-inflammatory condition that has been described in numerous organ systems. Generally, a confident diagnosis of IgG4-related disease requires the presence of two of three major histological features. These include a dense lymphoplasmacytic infiltrate, storiform-type fibrosis and obliterative phlebitis. Further supporting evidence includes elevated IgG4 levels, both in serum and histologically, as well as an IgG4+/IgG+ plasma cell ratio of greater than 40% on histology. We report a case of a 46-year-old man initially presenting with elevated blood glucose levels and diabetic symptoms and subsequently found to have a 10 cm irregular hepatic mass on radiologic imaging. His total serum IgG levels were elevated; however, IgG4 levels were on the high end of normal range. Histology revealed diffuse areas of dense plasma-lymphocytic infiltrate and collagenized fibrosis. Plasma cells were mature, polyclonal and did not exhibit atypia. The infiltrate contained focal nonnecrotizing granulomas and giant cells, and neither storiform fibrosis nor obliterative phlebitis was noted. On immunohistochemistry IgG immunostain was strong and diffusely positive, and IgG4 varied in concentration from areas of more than 200 cells/hpf, to areas of 30–40 plasma cells/hpf. IgG4 to IgG ratio was estimated to be less than 20%. The histological and immunohistochemical features support a diagnosis of a fibrohistiocytic type of inflammatory pseudotumor. However, given the dense lymphoplasmacytic infiltrate and elevated number of IgG4 plasma cells, an unusual variant of IgG4-RD is possible. Further studies of hepatic pseudotumors should be conducted in order to delineate sharper distinctions differentiating the two tumor types in the liver.
IgG4-Related Disease
Histology
Immunostaining
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The nationally-recognized Susquehanna
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