Haluk Tarık Kani

Marmara University

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

ÖA

Özlen Atuğ

Marmara University

YÖ

Yeşim Özen Alahdab

Marmara University

İE

İlkay Ergenç

Marmara University

Nİ

Neşe İmeryüz

Marmara University

Yusuf Yılmaz

Recep Tayyip Erdoğan University

CÖ

Coşkun Özer Demirtaş

Marmara University

Munkhtsetseg Banzragch

Istanbul University

ÇK

Çağlayan Keklikkıran

Recep Tayyip Erdoğan University

Daryl Ramai

University of Utah

Alptekin Temizel

Middle East Technical University

Cooperative Institutions

European Foundation for the Study of Chronic Liver Failure

212

Marmara University

138

Istanbul University

University Gastroenterology

Sağlık Bilimleri Üniversitesi

University of Pecs

Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas

Centro de Investigación Biomédica en Red

Universitat de Barcelona

University College London

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

P137 Sexual dysfunction in inflammatory bowel disease patients

Journal of Crohn s and Colitis (2014)

Ömer Yanartaş Haluk Tarık Kani Munkhtsetseg Banzragch Ercan Bıçakcı Ayşe Sakallı Kani

Clinical: Diagnosis & outcome S119 whose SES-CD was 3 whereas it was 88% in patients whose SES-CD was 2 (p < 0.01).This tendency was observed both in patients who were treated with/without biologics.Cox regression analysis after adjustment of possible confounding factors revealed that SES-CD 2 was found to be independent determinants of non-relapse (HR 0.17; 95% CI 0.06 0.48).Conclusions: The present study demonstrated that endoscopic remission (SES-CD 2) predicted long-term prognosis even in patients with clinical remission.

10.1016/s1873-9946(14)60259-2

Cite

Citations (0)

P0480 Evaluating the risk factors of surgery and postoperative complications in stricturing Crohn’s Disease

Journal of Crohn s and Colitis (2025)

Emil Yunusov Betül Piyade İlkay Ergenç Mahmut TAŞÇI Nisanur Sariyar

Abstract Background Strictures can be developed in approximately half of the Crohn’s disease (CD) patients during the course of the disease. Stricturing CD can be treated by medical, endoscopic and surgical options. In this study, we investigated the risk factors of CD related surgery and postoperative complications in stricturing CD. Methods We included the patients with stricturing Crohn’s disease who were followed up in our inflammatory bowel disease specific outpatient clinic between 1989 and 2024. Demographic and clinical data were collected retrospectively from the hospital electronic system and patient files. We divided our cohort into two groups as with and without CD-related surgery, and compared these two groups in terms of factors affecting the need for surgery. We examined the CD-related surgery groupin terms of the development of complications within 90 days following surgery. Results A total of 129 patients were included in the study. The mean age was 40.26 ± 14.13 years, and 59 (45.7%) of the patients were female. Sixty-two (48.1%) patients had tobacco exposure or were currently smoking. Nine (7.0%) patients had multiple strictures. Intestinal fistula was present in 35 (68.6%) patients in the surgical group, and it was found to be significantly higher compared to the non-surgical group (p=0.02). While 63 (63.6%) patients in the surgical group had a history of biological use, 36 (36.4%) patients in the non-surgical group had biological exposure, and this difference was statistically significant (p=0.003). Complications developed in 23 (31.5%) of the operated patients in the first 90 days after the operation (19 infectious, 8 non-infectious). Intestinal fistula, multiple stenoses and biological exposure (p = 0.02, p = 0.02, p = < 0.0001, respectively) were observed at a higher rate in the group with complications. In multivariate analysis, biological exposure was found to be a risk factor for surgery (p = 0.01; RR: 3.45), and the presence of abscess was found to be a risk factor for the development of complications following surgery (p = 0.01, RR: 8.09). Conclusion In our study, the presence of intestinal fistula and exposure to biological agents were found to be higher in the surgical group. In line with the current literature, the use of biological agents was found to be a factor affecting the need for surgery, and the presence of abscess was found to be a factor affecting postoperative complications (1, 2). References 1.Bossuyt P, Debeuckelaere C, Ferrante M, de Buck van Overstraeten A, Vanbeckevoort D, Billiet T, Wolthuis A, Cleynen I, Van Assche G, D’Hoore A, Vermeire S. Risk Stratification for Surgery in Stricturing Ileal Crohn’s Disease: The BACARDI Risk Model. J Crohns Colitis. 2018 Jan 5;12(1):32-38. 2.Celentano V, Giglio MC, Pellino G, Rottoli M, Sampietro G, Spinelli A, Selvaggi F; Italian Society of Colorectal Surgery SICCR. High complication rate in Crohn’s disease surgery following percutaneous drainage of intra-abdominal abscess: a multicentre study. Int J Colorectal Dis. 2022 Jun;37(6):1421-1428.

10.1093/ecco-jcc/jjae190.0654

Cite

Citations (0)

Indications, functional and quality of life outcomes of new pouch creation during re-do ileal pouch anal anastomosis: A comparative study with existing pouch salvage

Surgery (2021)

Eren Esen Hasan T. Kirat Arman Erkan Erman Aytaç Joanna Esterow

Pouch

10.1016/j.surg.2021.06.026

Cite

Citations (6)

Clinical significance of isolated abnormal intestinal findings in magnetic resonance enterography in patients with suspected small bowel disease

Abdominal Radiology (2019)

Yeşim Özen Alahdab Coşkun Özer Demirtaş Haluk Tarık Kani Davut Tüney Lamia Şeker

Clinical Significance

Terminal ileum

Abnormality

10.1007/s00261-019-02297-5

Cite

Citations (1)

Growing burden of nonalcoholic fatty liver disease in Turkey: A single-center experience

The Turkish Journal of Gastroenterology (2019)

Yusuf Yılmaz Haluk Tarık Kani Coşkun Özer Demirtaş Eda Kaya Aybuke Sapmaz

Background/Aims: Nonalcoholic fatty liver disease (NAFLD), which consists of nonalcoholic fatty liver (NAFL) and nonalcoholic steatohepatitis (NASH), is a growing epidemic in Turkey, considering the recent alarming prevalence of 48.3%.Patients with NASH and/or liver fibrosis are more likely to progress to advanced liver disease.In this single-center study, we sought to describe the clinical and histological characteristics of a sample of Turkish patients with biopsy-proven NAFLD, who were enrolled over a 4-year period.Materials and Methods: This is a retrospective analysis of prospectively collected data from a total of 468 patients (224 males, 244 females; median age, 47 [18-71].The study cohort consisted of patients with biopsy-proven NAFLD who were followed up at our outpatient clinic from 2009 to 2010 and from 2017 to 2018.Histological classification of the biopsies was performed according to the Steatosis, Activity and Fibrosis (SAF) scoring allowing the use of Fatty Liver Inhibition of Progression (FLIP) algorithm and the NAFLD Activity Score (NAS) scoring system.Results: Based on the SAF scoring, most patients (90.4%) had biopsy-proven NASH, whereas the NAFL was much rarer (9.6%).The prevalence of significant fibrosis (≥F2), advanced fibrosis (≥F3), and cirrhosis (F=4) was 35.0%, 17.5%, and 3.8%, respectively.The percentage of lean, overweight, and obese patients with NAFLD was 6.4%, 32.6%, and 61%, respectively.Metabolic syndrome was prevalent in 63% of the patients and Type 2 diabetes mellitus in 33.5%. Conclusion:The growing burden of NAFLD as a public health problem in Turkey is underscored by its marked histological severity in terms of NASH and fibrosis.Well-conducted clinical trials will be essential for slowing down the NASH progression.

Steatohepatitis

10.5152/tjg.2019.19072

Cite

Citations (28)

Histologic Predictors of Clinical Outcomes and Healthcare Utilization in Patients With Ileal Pouch-Anal Anastomosis

Inflammatory Bowel Diseases (2023)

Sam S. Chang Simon Hong David Hudesman Feza H. Remzi Katherine Sun

Abstract Background The prognostic significance of histology in ileal pouch-anal anastomosis (IPAA) remains unclear. The aim of this study was to evaluate if histologic variables are predictive of IPAA clinical outcomes and healthcare utilization. Methods This was a retrospective cohort study of patients with IPAA undergoing surveillance pouchoscopy at a tertiary care institution. Pouch body biopsies were reviewed by gastrointestinal pathologists, who were blinded to clinical outcomes, for histologic features of acute or chronic inflammation. Charts were reviewed for clinical outcomes including development of acute pouchitis, chronic pouchitis, biologic or small molecule initiation, hospitalizations, and surgery. Predictors of outcomes were analyzed using univariable and multivariable logistic and Cox regression. Results A total of 167 patients undergoing surveillance pouchoscopy were included. Polymorphonuclear leukocytes (odds ratio [OR], 1.67), ulceration and erosion (OR, 2.44), chronic inflammation (OR, 1.97), and crypt distortion (OR, 1.89) were associated with future biologic or small molecule initiation for chronic pouchitis. Loss of goblet cells was associated with development of chronic pouchitis (OR, 4.65). Pyloric gland metaplasia was associated with hospitalizations (OR, 5.24). No histologic variables were predictive of development of acute pouchitis or surgery. In an exploratory subgroup analysis of new IPAA (<1 year), loss of goblet cells was associated with acute pouchitis (OR, 14.86) and chronic pouchitis (OR, 12.56). Pyloric gland metaplasia was again associated with hospitalizations (OR, 13.99). Conclusions Histologic findings may be predictive of IPAA outcomes. Pathologists should incorporate key histologic variables into pouchoscopy pathology reports. Clinicians may need to more closely monitor IPAA patients with significant histologic findings.

Pouchitis

Metaplasia

Pouch

10.1093/ibd/izac277

Cite

Citations (3)

Levofloxacin for the treatment of severe refractory BK virus-associated hemorrhagic cystitis in hematopoietic stem cell transplantation recipients: A report of three cases

Oncology Letters (2014)

Tayfur Toptaş Isik Kaygusuz-Atagunduz Haluk Tarık Kani Cafer Adıgüzel Tülin Firatli‐Tuglular

BK-virus (BKV) is an important etiological agent for late-onset hemorrhagic cystitis (HC) in patients undergoing hematopoietic stem cell transplantation. Late-onset HC causes significant morbidity among these patients. Therapeutic approaches remain predominantly symptomatic. Several treatment options have been used with variable success rates. Cidofovir has the highest specificity against BKV; however, its lack of availability in the majority of countries, high costs and potential nephrotoxic effects limit its use. The present study reports three cases of severe and prolonged BKV-associated HC (BKHC). HC was resolved in all three of the patients using oral levofloxacin. Thus, levofloxacin may be an effective treatment modality for achieving complete clinical and molecular response in patients with refractory, severe BKHC.

Hemorrhagic cystitis

Refractory (planetary science)

10.3892/ol.2014.2381

Cite

Citations (17)

Higher liver stiffness scores are associated with early kidney dysfunction in patients with histologically proven non-cirrhotic NAFLD

Diabetes & Metabolism (2019)

Dan‐Qin Sun F.-Z. Ye Haluk Tarık Kani Jianjing Yang Kenneth I. Zheng

Transient elastography

10.1016/j.diabet.2019.11.003

Cite

Citations (29)

P101 Vitamin D deficiency in inflammatory bowel disease patients

Journal of Crohn s and Colitis (2014)

Haluk Tarık Kani Nazım Can Demircan Dilek Yazıcı Ercan Bıçakcı Munkhtsetseg Banzragch

Poster presentations Extraintestinal (n = 11) Intestinal (n = 9) p EZN 6 (55%) 1 (11%) 0.07 PCR 11 (100%) 4 (57%) 0.043 Culture 11 (100%) 7 (78%) 0.19 Conclusions: In contrast to previous non European reports culture of colonoscopic biopsy specimens is an highly SENS/SPEC to differentiate GITB from other ileo-cecal inflammations.Different methodological details, in sampling and processing, and the presence of exITB may have some influence on the results.Higher theoretical contamination chance with in house nested PCR may increase false (+) rate.

10.1016/s1873-9946(14)60223-3

Cite

Citations (0)

S0215 Gender and Racial Disparities in Colorectal Cancer Incidence and Survival: A Population-Based Study

The American Journal of Gastroenterology (2020)

Daryl Ramai Haluk Tarık Kani Ogenetega Madedor Olivia W. Brooks Andrew Ofosu

INTRODUCTION: Colorectal cancer (CRC) is the third common cause of cancer death in the US. The incidence of CRC is higher in minority racial and ethnic groups. Traditionally, CRC has had a higher mortality rate in men when compared to women. However, studies assessing trends among sex and racial groups on the incidence and mortality of CRC is lacking. We aim to investigate disparities in CRC by reviewing a large national cancer registry. METHODS: This is a retrospective cross-sectional study of the Surveillance, Epidemiology and End Results Registry (SEER) of individuals aged 45–79 years from 2000 to 2017. Race was classified as White, Black, American Indian/Alaska Native, and Asian or Pacific Islander. Annual percent change (APC) and incidence risk ratios (IRR) were calculated for sex and race. Kaplan-Meier estimations and log-rank tests were used to evaluate cancer-specific survival outcomes. Statistical significance was set at P < 0.05. RESULTS: Among 690,450 patients, there were 512,285 patients age 45–79 years diagnosed with CRC from 2000 to 2017. A higher proportion of patients had distal tumors versus proximal tumors (62% vs 38%, P < 0.001). SEER summary staging showed that most tumors were localized (40%) compared to regional (35%), distant cancer (20%), and unknown (4%). Approximately 23% of tumors on presentation occurred in the rectum (n = 114,873), followed by 21% in the sigmoid (102,850), 14% in the cecum (70,084), 12% in the ascending colon (n = 60,227), and 29.5% other locations. During the study period, the incidence of CRC decreased for both males and females, respectively (APC −2.14 vs −1.81). Amongst all racial groups, African American showed the least decline in incidence of CRC. African American females showed the highest risk for CRC (IRR 1.34; 95% CI 1.32–1.36, P < 0.001) compared to other females or males from different racial groups [Figure 1]. Subgroup analysis using Kaplan Meier estimations showed that African American females had the poorest 5-year survival rate (56%) compared to White females (66%), American Indian/Alaska Native females (58%), and Asian or Pacific Islander females (66%). Among males, American Indian/Alaska Natives had the poorest 5-year survival (54%) compared to African American males (61%), White males (66%), and Asian or Pacific Islander males (66%). CONCLUSION: Overall, the incidence of colorectal cancer is declining. However, the incidence of CRC remains highest in African Americans females who are also burden with poor survival rates.Figure 1.: Forest plot for Incidence Rate Ratios (IRR) for colorectal cancer (CRC) based on gender and race/ethnicity.Table 1.: One through 5-year survival rates based on gender and race/ethnicity.

10.14309/01.ajg.0000702908.72527.5f

Cite

Citations (0)