Filiz Canpolat

Memorial Ankara Hospital

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BÇ

Bengü Çevirgen Cemil

Sağlık Bilimleri Üniversitesi

Fatma Eskioğlu

Sağlık Bilimleri Üniversitesi

Müzeyyen Gönül

Ministry of Health

Murat Alper

University of Health Sciences

Hatice Ataş

Memorial Ankara Hospital

Havva Kaya Akış

Ministry of Health

Selda Pelin Kartal

Memorial Ankara Hospital

Gökçe Işıl Kurmuş

Memorial Ankara Hospital

Murat Oktay

Istanbul Memorial Hospital

Demet Yılmazer

Dışkapı Yıldırım Beyazıt Eğitim ve Araştırma Hastanesi

Cooperative Institutions

Sağlık Bilimleri Üniversitesi

Dışkapı Yıldırım Beyazıt Eğitim ve Araştırma Hastanesi

Ministry of Health

University of Health Science

University of Health Sciences Antigua

Memorial Ankara Hospital

Gazi University

Psychiatric Association of Turkey

Hacettepe University

University of Health Sciences

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Long-Pulsed Nd:YAG Laser Treatment for Nail Psoriasis

Dermatologic Surgery (2017)

Selda Pelin Kartal Filiz Canpolat Müzeyyen Gönül Can Ergin Zeynep Gençtürk

Psoriasis is a chronic inflammatory skin disease in which lesions display angiogenesis and increased vascularity.The long-pulsed 1,064-nm neodymium:yttrium-aluminum-garnet (Nd:YAG) laser treats vascular lesions which suggests that it might also be used to treat nail psoriasis.Sixteen patients (10 males and 6 females) with isolated nail psoriasis or nail with only mild cutaneous involvement were enrolled in the study. Nails were treated for 3 sessions with long-pulsed 1,064-nm Nd:YAG laser once monthly. During the course of the treatment, nail bed and matrix Nail Psoriasis Severity Index (NAPSI) scores were recorded.The mean baseline NAPSI score was 26 ± 7.2. The means of total NAPSI scores after the first, second, and third treatment sessions were as follows: 22 ± 6.6, 13 ± 6, and 5.7 ± 4.3, respectively. The decline in NAPSI score was statistically significant. At the end of the 3 treatment sessions, both nail bed and matrix lesions significantly responded to Nd:YAG laser treatment.The Nd:YAG laser is a promising treatment option for nail psoriasis.

Nail matrix

Nd:YAG laser

Vascularity

Laser Treatment

10.1097/dss.0000000000001294

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De Novo Malignancies After Kidney Transplant: Where Do We Stand and Does the Head and Neck Region Require More Caution?

Experimental and Clinical Transplantation (2023)

Gülay Ulusal Okyay Fatma Ayerden Ebinç Kadir Gökhan Atılgan Murat Alper Sebat Karamürsel

The aim of this study was to investigate the characteristics of de novo malignancies arising in kidney transplant recipients followed in a tertiary hospital in Turkey and to examine the tumors in the head and neck region as a subgroup.Data from kidney transplant recipients treated at our institution between January 2010 and July 2022 were retrospectively analyzed in this single-center study. Data regarding malignancies were noted according to the pathologists' reports. In situ malignancies and those arising after graft loss were not evaluated.The study population comprised 231 patients (165 men; 71.4%) with a median follow-up of 11 years (2853 patient-years). The recipients had a higher cancer risk than the general population (standardized incidence rate = 3.04; 95% CI, 1.82-4.26). Thirty de novo malignant tumors were detected in 24 patients (10.4%). The mean age at diagnosis of cancer was 54.88 ± 11.44 years. The median time from transplant to cancer diagnosis was 11.5 years (range, 7-18.8 y). Nonmelanoma skin cancers (56.7% of all tumors) were the most common malignancies. Twenty-two lesions (73.3%) that developed in 17 patients (7.4%) were localized to the head and neck region: 15 (68.2%) were cutaneous and 7 (31.8%) were noncutaneous. The median time from transplant to head and neck cancer diagnosis was 12 years (range, 7.5-17.5 y). Mortality rate was higher in cancer patients (10 [41.7%] vs 17 [8.2%]; P < 0.01).The incidence of de novo malignancy in kidney transplant recipients was relatively higher compared with previous data. Nonmelanoma skin cancers were the most common type. Three-quarters of all lesions were in the head and neck region, and two-thirds were of cutaneous origin.

Kidney cancer

10.6002/ect.2022.0283

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Evaluation of Mean Platelet Volume in Patients With Behcet's Disease as an Indicator of Vascular Thrombosis.

PubMed (2018)

Hatice Ataş Filiz Canpolat Fatma Eskioğlu

Patients with Behcet's disease (BD) are recognized with increased risk for venous and/or arterial thrombosis. Thrombotic tendency of BD is not known. Vascular injury, loss and dysfunction/hyperfunction of endothelial cells are believed to play a role in thrombosis development. Injury and inflammation due to vasculitis can cause platelet response with increase in mean platelet volume (MPV) and thrombosis in BD. In this study, we aimed to compare the levels of MPV between patients with BD and healthy controls, and also show its effect on thrombosis.One hundred patients with BD and 100 healthy controls were evaluated for MPV levels with clinical findings in age-gender matched case-control study. The variables of patients and controls were compared and correlated using chi-square, Mann-Whitney U and Spearman tests. Logistic regression analysis was used to determine independent predictors of vascular involvement and thrombosis.Mean MPV was significantly higher in patients with BD than healthy controls (MPV; Patients: 9.2 ± 0.9 [7.3-12.9] vs. Controls: 8.2 ± 0.6 [6.8-10.6] fl; P<0.0001). Platelets levels were lower than controls, but not significantly (236 ± 52.3 [112-451] vs. 245 ± 52.8 [141-467] x109 /L, P=0.55). Negative correlation was found between platelet count and MPV in patients (r = -0.51, P=0.01). Presence of erythema nodosum (EN) and MPV were determined as predictors for vascular involvement and thrombosis (EN: P<0.0001, OR [95% CI] = 35.4 [6.3-178.2]; MPV: P<0.0001, OR [95% CI] = 12.8 [4.1-24.3]).MPV is a simple measurement for indirect monitoring of platelet activity and thrombotic potential. MPV and EN may be independent risk factors for vascular thrombosis in BD. Patients with higher MPV levels and EN in BD, might have been pursued closely for enhancing thrombosis. We advise to check the MPV and put the patients on anticoagulation if it is high.

Mean platelet volume

Erythema Nodosum

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Infliximab-induced discoid lupus erythematosus

Lupus (2013)

BC Cemil Hatice Ataş Filiz Canpolat Yasemin Akca Rüstem Şaşmaz

Anti-tumor necrosis factor-alpha (TNF-α) immunotherapy is currently used in the treatment of various inflammatory diseases such as rheumatoid arthritis, psoriasis, psoriatic arthritis, ankylosing spondylitis and Crohn’s disease. Infliximab is a chimeric monoclonal antibody that binds to transmembrane-bound and soluble TNF-α. Previously, a discoid lupus erythematosus-like eruption linked to its use was rarely reported in patients with rheumatoid arthritis. We present a case of rheumatoid arthritis which developed such an eruption after treatment with infliximab. The lesions resolved after the discontinuation of infliximab. In the present case, the clinical, serological and immunohistochemical features of our patient are discussed with the literature.

Discoid lupus erythematosus

10.1177/0961203313479423

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Citations (26)

Serum and erythrocyte adenosine deaminase activities in patients with Behçet's disease

International Journal of Dermatology (2006)

Filiz Canpolat Mehmet Ünver Fatma Eskioğlu Şebnem Kösebalaban Selda Pelin Kartal Durmazlar

Objectives Adenosine deaminase (ADA) is a non‐specific marker of the activation of the T cell, which has an important role in the etiology of Behçet's disease (BD). The purpose of this study was to investigate the determination of ADA activity as an index of T‐lymphocyte function in BD, which is known to have an T‐cell‐mediated immune response. Materials and Methods Adenosine deaminase activities in both serum and erythrocytes were measured in 23 untreated patients with BD and in 20 healthy controls. The patients with BD were divided into two groups: active ( n = 10) and inactive ( n = 13). Results When compared with the control group, serum ADA activity was high ( P < 0.01) and erythrocyte ADA activity was significantly low ( P < 0.01) in BD. Serum ADA activity of active BD was higher than that of inactive BD ( P < 0.01), but erythrocyte ADA activity was found to be lower in active BD than inactive BD ( P < 0.01). Comment These findings may provide an additional benefit for the diagnosis of BD and sub‐typing of active and inactive BD.

Etiology

10.1111/j.1365-4632.2006.02892.x

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Citations (18)