Mohamed A. El‐Shanawany

Badr University in Cairo

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Invitro and invivo cultivation of Pergularia tomentosa for cardenolides

IOSR Journal of Pharmacy and Biological Sciences (2014)

Hifnawy M.S.Mohamed A. El‐Shanawany Khalifa M.M.Youssef A.K Metwally Bekhit

The importance for the conservation of the Egyptian desert plant Pergularia tomentosa was encouraged after the isolation and identification of the highly stable and water soluble cardiac glycosides with very interesting pharmacological activities and wide safety margins.The study included agricultural and tissue culture experiments for the possible production of these important cardenolides in high concentrations.Calli formation and growth obtained from different explants were significantly affected by many factors tested.The HPLC analysis of the extracts of both cultivated plants samples and calli from tissue culture experiments demonstrated promising results.All extracts showed the presence of the major ghalakinoside, in variable concentrations.The highest results were obtained from the irrigated plants in the agricultural experiments and after progesterone addition in tissue culture experiments.

10.9790/3008-09214052

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Citations (2)

CCDC 238129: Experimental Crystal Structure Determination

The Cambridge Structural Database (2005)

A.A. Ahmed S. El-Moghazy Mohamed A. El‐Shanawany Abdelghani Hajji Joseph J. Karchesy

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/cc7zslk

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A new xanthone from the roots of Centaurium spicatum

Phytochemistry Letters (2011)

Mohamed A. El‐Shanawany Gamal A. Mohamed Alaa M. Nafady Sabrin R. M. Ibrahim Mohamed M. Radwan

Xanthone

Antiprotozoal

10.1016/j.phytol.2010.12.008

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Citations (24)

Nutritional, Antioxidant, Antimicrobial, and Anticholinesterase Properties of Phyllanthus emblica: A Study Supported by Spectroscopic and Computational Investigations

Metabolites (2023)

Mohamed A. A. Orabi Aso Hameed Hasan Sameh AbouZid Dalia El Amir Mona H. Hetta

Dietary fruits and vegetables play a vital role as food and drugs and are the main sources of antioxidant defences against degenerative diseases, such as brain dysfunctions, cardiovascular diseases, immune system deteriorations, and cancers, brought on by oxidative damage. Phyllanthus emblica is a significant herbal remedy used in conventional medicine to recover lost strength and power. In this research, the potential value of Phyllanthus emblica as a food and drug is researched. The total phenolic, total flavonoid, and total tannin contents as well as the nutritional value, vitamin C, vitamin E, and mineral contents of different organs of P. emblica were evaluated. The antioxidant and antimicrobial activities of extracts and fractions of different organs of P. emblica were determined. A total of eleven flavonoids, simple phenolic, tannin-related phenolic, and tannin molecules were isolated from a hydroalcoholic extract of the leaves and fruits. The structures were identified by spectroscopic data and comparison with the literature values as gallic acid (1), naringenin 7-O-(6″-O-galloyl)-β-D-glucopyranoside (2), 3,3′-di-O-methyl ellagic acid-4′-O-β-d-glucopyranoside (3), 1-O-galloyl glycerol (4), 1,6-di-O-galloyl-β-d-glucopyranoside (5), flavogallonic acid bislactone (6), corilagin (7), ethyl gallate (8), urolithin M5 (9), (E)-p-coumaroyl-1-O-β-d-glucopyranoside (10), and 1,2,4,6-tetra-O-galloyl-β-d-glucopyranoside (11). Among them, compounds 3 and 10 are first isolated from the plant. Molecular docking was performed to investigate the comparative interactions between positive controls (galantamine and donepezil) and selected compounds utilizing acetylcholinesterase (4EY7) as a target receptor. Results exhibited the potency of these compounds against the target receptor. In summary, P. emblica has a wealth of minerals, vitamins C and E, and polyphenolic phytochemicals that may work together to treat infectious disease, prevent and/or treat oxidative-damage-related illnesses including Alzheimer’s disease.

Phyllanthus emblica

Ellagic Acid

Tannin

Methyl gallate

Phyllanthus

10.3390/metabo13091013

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Citations (9)

PHYTOCHEMICAL STUDY OF THE LEAVES OF ZIZIPHUS SPINA-CHRISTI L. WILLD

Bulletin of Pharmaceutical Sciences Assiut (1985)

Ahmed S. Ali Mohamed A. El‐Shanawany M. Mesbah

Investigation of the leaves of Z. spina-christi L. Willd resulted in the isolation and identification of ceryl alcohol, b-sitosterol, ursolic acid, betulinic acid, fatty acids (myristic, stearic, oleic, linoleic, linoleic and arachidic acids), flavonoidal compounds (taxifolin, dihydrokaempferol, taxifolin-3-O-glvcoside and apigenin-7-O-glucoside). In addition, a chromatospectrophotometric method was adopted for quantitative estimation of the flavonoidal content.

Phytochemical

10.21608/bfsa.1985.75704

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New secoiridoid ester of swertiamarin and secoxyloganic acid with hepatoprotective activity from Centaurium spicatum L.

Journal of Pharmacy & Pharmacognosy Research (2015)

Ahmed E. Allam Alaa M. Nafady Mohamed A. El‐Shanawany Fumide Takano Tomihisa Ohta

Context: Centaurium spicatum (L.) Fritsch (Gentianaceae) is an annual herb occurring in Southern Europe and Northern Africa where it is used in traditional medicine for treatment of numerous illness. Aims: To isolate compounds from C. spicatum having hepatoprotective activity. Methods: Structure elucidation of the new compound was established on the basis of 1D and 2D NMR analyses including 1H-, 13C- NMR, DEPT-135 NMR, HMQC, HMBC and H- H HOHAHA experiments in addition to FAB+ and HRFAB+ Mass spectrometry. In vivo transaminases inhibition activity was carried out. Results: A new ester of swertiamarin and secoxyloganic acid (1) was isolated from C. spicatum in addition to its known components secoiridoids swertiamarin (2) and secoxyloganic acid (3). All tested secoiridoids have transaminases inhibition activity with different values for each compound 1, 2, 3 (86, 83, 81%) for SGOT and (96, 93, 91%) for SGPT, respectively. Conclusions: The new ester compound from C. spicatum has hepatoprotective activity over than its components.

DEPT

10.56499/jppres15.058_3.3.69

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Citations (5)

Blepharisides A and B, new flavonol glycosides from Blepharis ciliaris growing in Saudi Arabia

Phytochemistry Letters (2014)

Gamal A. Mohamed Sabrin R. M. Ibrahim Ehab S. Elkhayat Samir A. Ross Hanaa M. Sayed

Acanthaceae

CCL4

Anti-inflammatory

10.1016/j.phytol.2014.12.018

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Citations (19)

FLAVONOID GLYCOSIDES FROM THE LEAVES OF SALVADORA PERSICA L.

Bulletin of Pharmaceutical Sciences Assiut (1997)

Ameena Ali M. Assaf Mohamed A. El‐Shanawany Mohamed Kamel

From the leaves of Salvadora persica L. eleven flavonoidal glycosides are isolated and identified. Seven of them: Isorhamnetin-3-O-robinobioside, Kaempferol-3-O-robinobioxide, Narcissin, Kaempferol-3-Orutinoside, Isorhamnetin-3-O-b-galactoside, Astragalin and Isorhamnetin-3-O-b-D-glucoside are isolated for the first time form the genus Salvadora. While the others four are identified as: Isorhamnetin-3-(2,6-di-rhamnopyranosyl-galactopyranoside), Mauritianin, Isorhamnetin-3-O-(2-Glc-rhamnosylrutinoside) and Kaempferol-3-O-(2-Glc-rhamnosylrutinoside) and reported for the first time in family Salvadoraceae.

Isorhamnetin

Astragalin

10.21608/bfsa.1997.68759

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Citations (8)

PHARMACOGNOSTICAL STUDY OF KHAYA SENEGALENSIS A. JUSS GROWING IN EGYPT PART I: Botanical and Chemical Study of the Leaf.

Bulletin of Pharmaceutical Sciences Assiut (1984)

M. Mesbah M. Abd El-Hafiz Mohamed A. El‐Shanawany

Khaya

10.21608/bfsa.1984.89568

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Citations (0)