Craig A. Peters

The University of Texas Southwestern Medical Center

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Alan B. Retik

Boston Children's Hospital

Stuart B. Bauer

Boston Children's Hospital

Anthony Atala

Wake Forest University

Joseph G. Borer

Boston Children's Hospital

James Mandell

Boston Children's Hospital

David A. Diamond

University of Rochester

Hiep T. Nguyen

Christus Health

Carlo C. Passerotti

Universidade de São Paulo

Bartley G. Cilento

Boston Children's Hospital

Martin Kaefer

Riley Hospital for Children

Cooperative Institutions

Children's Defense Fund

301

Fermi National Accelerator Laboratory

253

Istituto Nazionale di Fisica Nucleare

250

University of Bologna

210

Harvard University

189

Instituto de Física de Cantabria

174

Universidad de Cantabria

167

Boston Children's Hospital

166

University of Florida

160

Duke University

156

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Signaling Through PI3K/Akt Mediates Stretch and PDGF-BB-Dependent DNA Synthesis in Bladder Smooth Muscle Cells

The Journal of Urology (2003)

Rosalyn M. Adam Jonathan A. Roth Hong-Lin Cheng Dana C. Rice Joseph El Khoury

Smooth muscle cells (SMC) of the bladder undergo hypertrophy and hyperplasia following exposure to sustained mechanical overload. Although superficial similarities in the response of the heart and bladder to hypertrophic stimuli suggest that similar molecular mechanisms may be involved, this remains to be demonstrated. In this study we compared signal transduction pathway activation in primary culture bladder SMC and cardiac myofibroblasts in response to cyclic stretch. The effects of growth factor stimulation on pathway activation in bladder SMC were also investigated.Primary culture rodent bladder SMC or cardiac myofibroblasts were subjected to cyclic stretch-relaxation in the absence or presence of pharmacologic inhibitors of the phosphoinositide-3-kinase, (PI3K)/Akt, extracellular signal-regulated kinase-mitogen activated protein kinase (Erk-MAPK) or the p38 stress-activated protein kinase-2 (SAPK2) pathways. In parallel experiments human bladder SMC were treated with platelet-derived growth factor-BB (PDGF-BB), heparin-binding EGF-like growth factor (HB-EGF) or fibroblast growth factor-2 (FGF-2). In each case the extent of DNA synthesis was determined by uptake of tritiated thymidine, and activation of specific signaling intermediates was determined by immunoblot analysis using antibodies to the non-phosphorylated and phosphorylated (activated) forms of Akt, p38 and Erk1/2.Akt and p38 were rapidly phosphorylated in stretched bladder SMC and cardiac myofibroblasts, and stretch-induced DNA synthesis in these cells was ablated with inhibitors of PI3K or p38 but not Erk-MAPK. Similarly, PDGF-BB up-regulated DNA synthesis in bladder SMC in a p38 and Akt-dependent manner.We conclude that distinct stimuli, such as mechanical stretch and PDGF-BB, promote DNA synthesis in bladder SMC through shared downstream signaling pathways. Furthermore, phenotypically similar cells from the bladder and heart show comparable pathway activation in response to stretch. These findings suggest that similar molecular mechanisms underlie the altered growth responses of the bladder and heart to mechanical overload. This study also provides the first report of Akt activation in bladder SMC and suggests that Akt, consistent with its pivotal role in cardiac hypertrophy, may also be a key regulator of remodeling in the SMC compartment of the bladder exposed to hypertrophic/hyperplastic stimuli in vivo.

Platelet-derived growth factor

10.1097/01.ju.0000063980.99368.35

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Citations (65)

Robotic assistance for manipulating a flexible endoscope

Lingxue Zhang Rahul Khare Emmanuel Wilson Siyuan Wang Craig A. Peters

Flexible ureteroscopes are widely used for inspection, access, and manipulation in the ureter and kidney during uretero-renoscopy. However, existing endoscope designs rely on decades-old manual controls for translation, rotation, and tip flexion. The development of a more intuitive and user-friendly control system has the potential to greatly enhance the safety, efficacy, and efficiency of endoscopic procedures. Based on a first generation prototype, our lab designed an ergonomically enhanced flexible endoscopy robotic system. The system was designed to enable the surgeon to operate the endoscope through a low cost game controller. The kinematics were analyzed considering the nonlinearity of flexion driving and cable slack. The kinematics control was combined with the direct control for the system. The initial evaluations show the feasibility of this approach.

Endoscope

10.1109/icra.2014.6907650

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Citations (11)

INTERMITTENT TESTICULAR TORSION: DIAGNOSTIC FEATURES AND MANAGEMENT OUTCOMES

The Journal of Urology (2005)

Samuel H. Eaton Marc Cendron Carlos R. Estrada Stuart B. Bauer Joseph G. Borer

No AccessJournal of UrologyTestis1 Oct 2005INTERMITTENT TESTICULAR TORSION: DIAGNOSTIC FEATURES AND MANAGEMENT OUTCOMES SAMUEL H. EATON, MARC A. CENDRON, CARLOS R. ESTRADA, STUART B. BAUER, JOSEPH G. BORER, BARTLEY G. CILENTO, DAVID A. DIAMOND, ALAN B. RETIK, and CRAIG A. PETERS SAMUEL H. EATONSAMUEL H. EATON , MARC A. CENDRONMARC A. CENDRON , CARLOS R. ESTRADACARLOS R. ESTRADA , STUART B. BAUERSTUART B. BAUER , JOSEPH G. BORERJOSEPH G. BORER , BARTLEY G. CILENTOBARTLEY G. CILENTO , DAVID A. DIAMONDDAVID A. DIAMOND , ALAN B. RETIKALAN B. RETIK , and CRAIG A. PETERSCRAIG A. PETERS View All Author Informationhttps://doi.org/10.1097/01.ju.0000177726.84913.ccAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Intermittent testicular torsion (ITT) is a poorly characterized condition but harbors potentially serious implications with regard to testicular viability. We report better characterization of the diagnostic features of ITT. Materials and Methods: We performed a retrospective review of all patients 1 to 18 years old seen from 1997 to 2003 at our institution diagnosed with ITT. Patients with acute scrotal pain and spontaneous resolution who underwent bilateral testicular fixation were included in the study. Results: A total of 50 patients meeting the inclusion criteria were identified with mean age at presentation of 12.2 years (range 4 to 17). The mean number of painful episodes before surgery was 4.3 (range 1 to 30). The most common presenting features were severe pain of rapid onset and resolution. Nausea and/or vomiting was reported in a quarter of the patients. Finding of a horizontal lie of the testes on examination was significantly associated (p <0.05) with the existence of the bell-clapper deformity. All patients underwent surgical fixation of the testes. There were no postoperative complications. Of 38 patients (97%) for whom followup was available 37 had complete resolution of symptoms (mean followup 7.9 months). Conclusions: ITT should be a diagnostic consideration in patients who present with recurrent acute scrotal pain with rapid spontaneous resolution. Recurrent severe pain with rapid onset and resolution seems to be highly characteristic. Horizontal lie on examination is highly correlated with the bell-clapper deformity at surgical exploration. Surgery may be recommended in these patients as it appears to result in pain relief in the majority, is likely to prevent future testicular infarction and is associated with low morbidity. References 1 : Intermittent testicular torsion. Pediatrics1986; 77: 908. Google Scholar 2 : Intermittent torsion: association with horizontal lie of the testicle. J Urol1991; 145: 1053. Link, Google Scholar 3 : Torsion of spermatic cord and testicular appendages. Urology1975; 5: 73. Google Scholar 4 : Elective orchiopexy for recurrent testicular torsion. J Urol1982; 127: 253. Link, Google Scholar 5 : The diagnosis and treatment of the acute scrotum in children and adolescents. Ann Surg1984; 200: 664. Google Scholar 6 : Torsion of the testis and allied conditions. Br J Surg1976; 63: 465. Google Scholar 7 : Intermittent torsion of the testis. J R Coll Surg Edinb1984; 29: 107. Google Scholar 8 : Recurrent subacute torsion: prospective study of effects on testicular morphology and function. J Urol1991; 145: 297. Link, Google Scholar 9 : Intermittent testicular pain: fix the testes. BJU Int2003; 91: 406. Google Scholar 10 : Incidence of the bell-clapper deformity in an autopsy series. Urology1994; 44: 114. Google Scholar 11 : Outcomes for surgical management of orchalgia in patients with identifiable intrascrotal lesions. Eur Urol2001; 39: 455. Google Scholar 12 : Intermittent torsion of the testis. Br Med J1988; 297: 525. Google Scholar 13 : Acute scrotal disorders: prospective comparison of color Doppler US and testicular scintigraphy. Radiology1990; 177: 177. Google Scholar 14 : Comparison of color Doppler sonography and radionuclide imaging in different degrees of torsion in rabbit testes. Acad Radiol1995; 2: 945. Google Scholar 15 : Critical validation of colour Doppler ultrasound in diagnostics of acute scrotum in children. Eur J Pediatr Surg2003; 13: 386. Google Scholar 16 : An analysis of clinical outcomes using color doppler testicular ultrasound for testicular torsion. Pediatrics2000; 105: 604. Google Scholar 17 : Acute scrotal symptoms in boys with an indeterminate clinical presentation: comparison of color Doppler sonography and scintigraphy. Radiology1998; 207: 223. Google Scholar 18 : Accuracy of Doppler sonography in the evaluation of acute conditions of the scrotum in children. J Pediatr Surg1994; 29: 1270. Google Scholar 19 : Torsion of the testis and its appendages. Br Med J1972; 1: 164. Google Scholar From the Department of Urology, Children's Hospital Boston, Boston, Massachusetts© 2005 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byPontari M (2018) When to Operate for Scrotal Pain?Journal of Urology, VOL. 190, NO. 1, (13-14), Online publication date: 1-Jul-2013.Figueroa V, Pippi Salle J, Braga L, Romao R, Koyle M, Bägli D and Lorenzo A (2012) Comparative Analysis of Detorsion Alone Versus Detorsion and Tunica Albuginea Decompression (Fasciotomy) with Tunica Vaginalis Flap Coverage in the Surgical Management of Prolonged Testicular IschemiaJournal of Urology, VOL. 188, NO. 4S, (1417-1423), Online publication date: 1-Oct-2012.Hayn M, Herz D, Bellinger M and Schneck F (2008) Intermittent Torsion of the Spermatic Cord Portends an Increased Risk of Acute Testicular InfarctionJournal of Urology, VOL. 180, NO. 4S, (1729-1732), Online publication date: 1-Oct-2008. Volume 174Issue 4 Part 2October 2005Page: 1532-1535 Advertisement Copyright & Permissions© 2005 by American Urological Association, Inc.Keywordsspermatic cord torsiontestisMetricsAuthor Information SAMUEL H. EATON More articles by this author MARC A. CENDRON More articles by this author CARLOS R. ESTRADA More articles by this author STUART B. BAUER More articles by this author JOSEPH G. BORER More articles by this author BARTLEY G. CILENTO More articles by this author DAVID A. DIAMOND More articles by this author ALAN B. RETIK More articles by this author CRAIG A. PETERS More articles by this author Expand All Advertisement PDF downloadLoading ...

10.1097/01.ju.0000177726.84913.cc

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Citations (92)

Laparoscopic management of duplication anomalies

CRC Press eBooks (2006)

Alberto Lais Craig A. Peters

Galen and Leonardo da Vinci were the first to propose that normal UVJ allowed unidirectional flow ofurine into the bladder and that VUR might be abnormal in humans.1,2 In 1893, Pozzi reported that VUR could occur in humans after noting an unexpected urine leakage from the accidentally severed ureter during a pelvic gynecologic procedure.3 The systematic identification of VUR came as the result of technologic advances in contrast radiography – voiding cystourethrography (VCUG). Initially, VUR was not thought to be a significant clinical problem for humans, although Bumpus speculated in 1924 that VUR was related to UTI and that in children, unlike adults, VUR was not associated with other urinary tract pathology.4 In 1930, Campbell found VUR in 12% of over 700 VCUGs but assumed that there was other underlying pathology as the cause of VUR.5 In 1944, Prather proposed that VUR was abnormal in children,6 and this notion gained increasing acceptance, after accumulating evidence suggested that VUR was typically absent in normal neonates and children. The modern era of clinical VUR management was ushered in by Hutch's observation that VUR and pyelonephritis might be causally related in paraplegic patients.7 Hodson, applying Hutch's concept to children, noted that VUR was more common in children with UTI and renal parenchymal abnormality.8,9 Other clinical and experimental observations soon followed, providing the anatomic and functional basis for the UVJ mechanism and the etiology of VUR.

10.1201/b13795-46

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Faculty Opinions recommendation of A reanalysis of the RIVUR trial using a risk classification system.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2018)

Craig A. Peters

10.3410/f.732224016.793554498

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Reconstructive Options in Genitourinary Rhabdomyosarcoma

The Journal of Urology (1996)

Barry P. Duel W. Hardy Hendren Stuart B. Bauer James Mandell Arnold H. Colodny

No AccessJournal of UrologyPediatric Urology1 Nov 1996Reconstructive Options in Genitourinary Rhabdomyosarcoma Barry P. Duel, W. Hardy Hendren, Stuart B. Bauer, James Mandell, Arnold Colodny, Craig A. Peters, Anthony Atala, and Alan B. Retik Barry P. DuelBarry P. Duel More articles by this author , W. Hardy HendrenW. Hardy Hendren More articles by this author , Stuart B. BauerStuart B. Bauer More articles by this author , James MandellJames Mandell More articles by this author , Arnold ColodnyArnold Colodny More articles by this author , Craig A. PetersCraig A. Peters More articles by this author , Anthony AtalaAnthony Atala More articles by this author , and Alan B. RetikAlan B. Retik More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)65540-XAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We attempted to develop a rational and consistent scheme for surgical reconstruction in patients with genitourinary rhabdomyosarcoma. Materials and Methods: We reviewed the records of 35 patients with resectable genitourinary rhabdomyosarcoma treated from 1970 to 1993. Results: Primary sites included bladder in 11 cases, prostate in 13, vagina/uterus in 9 and pelvic tumors of uncertain origin in 2. A total of 33 patients underwent surgery, including partial and radical cystectomy in 17 (bowel conduit diversion in 10, continent urinary diversion in 6 and ureterosigmoidostomy in 1). Overall 30 of the 33 surgical patients are free of disease 4 months to 24 years after diagnosis. Conclusions: A nonrefluxing colon conduit is appropriate at cystectomy. Continent diversion fashioned from the original conduit may be planned as the patient achieves a durable disease-free status. References 1 : Bladder and prostatic tumors in the Intergroup Rhabdomyosarcoma Study: IRS-I: results of therapy. Cancer1982; 50: 1472. Google Scholar 2 : Genitourinary rhabdomyosarcoma in children. Cancer1989; 63: 1600. Google Scholar 3 : Sequelae of treatment in 109 patients followed for 5 to 15 years after diagnosis of sarcoma of the bladder and prostate. A report from the Intergroup Rhabdomyosarcoma Study Committee. Cancer1993; 71: 2387. Google Scholar 4 : The use of continent diversion in the management of rhabdomyosarcoma of the prostate in childhood. J. Urol.1992; 147: 1602. Abstract, Google Scholar 5 : Replacement of the bladder by the urethral Kock pouch: functional results, urodynamics and radiological features. J. Urol.1989; 141: 1111. Link, Google Scholar Division of Urology, Department of Surgery, Children's Hospital and Department of Surgery, Harvard Medical School, Boston, Massachusetts.© 1996 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited ByCastagnetti M, Angelini L, Alaggio R, Scarzello G, Bisogno G and Rigamonti W (2018) Oncologic Outcome and Urinary Function after Radical Cystectomy for Rhabdomyosarcoma in Children: Role of the Orthotopic Ileal Neobladder Based on 15-Year Experience at a Single CenterJournal of Urology, VOL. 191, NO. 6, (1850-1855), Online publication date: 1-Jun-2014.Rigamonti W, Iafrate M, Milani C, Capizzi A, Bisogno G, Carli M and Glazel G (2018) Orthotopic Continent Urinary Diversion After Radical Cystectomy in Pediatric Patients With Genitourinary RhabdomyosarcomaJournal of Urology, VOL. 175, NO. 3, (1092-1096), Online publication date: 1-Mar-2006.Ferrer F, Isakoff M and Koyle M (2018) Bladder/Prostate Rhabdomyosarcoma: Past, Present and FutureJournal of Urology, VOL. 176, NO. 4, (1283-1291), Online publication date: 1-Oct-2006.MERGUERIAN P, AGARWAL S, GREENBERG M, BAGLI D, KHOURY A and McLORIE G (2018) OUTCOME ANALYSIS OF RHABDOMYOSARCOMA OF THE LOWER URINARY TRACTJournal of Urology, VOL. 160, NO. 3 Part 2, (1191-1194), Online publication date: 1-Sep-1998. Volume 156Issue 5November 1996Page: 1798-1804 Advertisement Copyright & Permissions© 1996 by American Urological Association, Inc.MetricsAuthor Information Barry P. Duel More articles by this author W. Hardy Hendren More articles by this author Stuart B. Bauer More articles by this author James Mandell More articles by this author Arnold Colodny More articles by this author Craig A. Peters More articles by this author Anthony Atala More articles by this author Alan B. Retik More articles by this author Expand All Advertisement PDF DownloadLoading ...

Ureterosigmoidostomy

Urinary diversion

Pelvic exenteration

10.1016/s0022-5347(01)65540-x

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Citations (33)

Urinary Levels of the Renal Tubular Enzyme N-Acetyl- β -D-Glucosaminidase in Unilateral Obstructive Uropathy

The Journal of Urology (1994)

Michael C. Carr Craig A. Peters Alan B. Retik James Mandell

No AccessJournal of Urology1 Feb 1994Urinary Levels of the Renal Tubular Enzyme N-Acetyl-β-D-Glucosaminidase in Unilateral Obstructive Uropathy Michael C. Carr, Craig A. Peters, Alan B. Retik, and James Mandell Michael C. CarrMichael C. Carr , Craig A. PetersCraig A. Peters , Alan B. RetikAlan B. Retik , and James MandellJames Mandell View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)34983-2AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Elevated urinary levels of the renal tubular enzyme, N-acetyl-ß-D-glucosaminidase (NAG), have been shown to be associated with reversible tubular damage and, therefore, may serve as an indicator of tubular damage in the setting of presumed obstruction uropathy. This study compares urinary NAG levels in children with apparent upper tract obstruction with normal children to assess the sensitivity of this assay for the detection of possible renal tubular damage. The study included 40 children 3 weeks to 16 years old with unilateral ureteropelvic junction obstruction (30) or primary obstructive megaureter (10). Urine was obtained from the bladder in all children and from the renal pelvis or ureter in 30 patients at surgery. Pelvic and ureteral urinary NAG levels were consistently higher than bladder levels. In patients with ureteropelvic junction obstruction NAG levels were 7 times higher than normal (76 units per mg., p <0.0001) and 3 times higher than normal in patients with obstructive megaureter (29 units per mg., p <0.001). The mean bladder urinary NAG levels in patients with ureteropelvic junction obstruction (17.6 units per mg. creatinine, standard error of mean 2.01, p <0.001) and megaureters (19.2 units per mg. creatinine, standard error of mean 3.6, p <0.049) were elevated above control patients (10.6 units per mg. creatinine, standard error of mean 1.02). Elevated urinary NAG levels in the renal pelvis, ureter and bladder may be helpful in identifying upper tract obstruction, which if left untreated, might cause progressive renal deterioration. © 1994 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byTaha M, Shokeir A, Osman H, Abd El-Aziz A and Farahat S (2007) Obstructed Versus Dilated Nonobstructed Kidneys in Children With Congenital Ureteropelvic Junction Narrowing: Role of Urinary Tubular EnzymesJournal of Urology, VOL. 178, NO. 2, (640-646), Online publication date: 1-Aug-2007.CHEVALIER R (2018) BIOMARKERS OF CONGENITAL OBSTRUCTIVE NEPHROPATHY: PAST, PRESENT AND FUTUREJournal of Urology, VOL. 172, NO. 3, (852-857), Online publication date: 1-Sep-2004.FURNESS P, MAIZELS M, HAN S, COHN R and CHENG E (2018) ELEVATED BLADDER URINE CONCENTRATION OF TRANSFORMING GROWTH FACTOR-beta 1 CORRELATES WITH UPPER URINARY TRACT OBSTRUCTION IN CHILDRENJournal of Urology, VOL. 162, NO. 3 Part 2, (1033-1036), Online publication date: 1-Sep-1999.Fung L and Atala A (2018) CONSTANT ELEVATION IN RENAL PELVIC PRESSURE INDUCES AN INCREASE IN URINARY N-ACETYL-beta-D-GLUCOSAMINIDASE IN A NONOBSTRUCTIVE PORCINE MODELJournal of Urology, VOL. 159, NO. 1, (212-216), Online publication date: 1-Jan-1998.Edelstein R, Bauer S, Kelly M, Darbey M, Peters C, Atala A, Mandell J, Colodny A and Retik A (2018) Long-Term Urological Response of Neonates With Myelodysplasia Treated Proactively With Intermittent Catheterization and Anticholinergic TherapyJournal of Urology, VOL. 154, NO. 4, (1500-1504), Online publication date: 1-Oct-1995. Volume 151Issue 2February 1994Page: 442-445 Advertisement Copyright & Permissions© 1994 by The American Urological Association Education and Research, Inc.KeywordskidneyglucosaminidaseenzymesMetricsAuthor Information Michael C. Carr Supported by the National Kidney Foundation/American Foundation for Urologic Disease Research Fellowship. More articles by this author Craig A. Peters More articles by this author Alan B. Retik More articles by this author James Mandell More articles by this author Expand All Advertisement PDF downloadLoading ...

Obstructive uropathy

Megaureter

Renal pelvis

Upper urinary tract

Urinary tract obstruction

10.1016/s0022-5347(17)34983-2

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Citations (73)

Legend in Green Velvet

Craig A. Peters

Velvet

Legend

Source

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AMIODARONE INDUCED EPIDIDYMITIS IN CHILDREN

The Journal of Urology (1998)

Joel C. Hutcheson Craig A. Peters David A. Diamond

No AccessJournal of UrologyPediatric Urology1 Aug 1998AMIODARONE INDUCED EPIDIDYMITIS IN CHILDREN JOEL HUTCHESON, CRAIG A. PETERS, and DAVID A. DIAMOND JOEL HUTCHESONJOEL HUTCHESON More articles by this author , CRAIG A. PETERSCRAIG A. PETERS More articles by this author , and DAVID A. DIAMONDDAVID A. DIAMOND (DIAMOND) Requests for reprints: Children's Hospital, 300 Longwood Ave., Boston, Massachusetts 02115. More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)62950-1AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Amiodarone is an antiarrythmic agent, which is often successfully used when all other antiarrythmics have failed. Sterile epididymitis is a recognized complication of treatment in adults, occurring in up to 11% of patients. To date there have been no reported cases of amiodarone induced epididymitis in children. We present a previously unrecognized cause of epididymitis in boys. Materials and Methods: The medical records, including radiographic imaging, pathology and operative reports, of 2 postpubertal boys who had sterile epididymitis after prolonged therapy with amiodarone were reviewed. Results: In both cases the onset of scrotal and subsequent evaluation led to diagnosis of epidydimitis. Amiodarone was determined to be the cause, and cessation of the drug resulted in symptom resolution in 1 case. Conclusions: While it remains uncertain, the pathophysiology of amiodarone induced epididymitis is likely related to its high concentration in testicular tissue. Recognition that amiodarone is a rare but significant cause of epididymitis in children is important to prevent unnecessary surgery in high risk patients. Amiodarone induced epididymitis in children tends to be a self-limited process and of secondary importance to the serious cardiac disease. Whereas discontinuing amiodarone risks sudden cardiac death, a reduction in dosage or temporary cessation of the drug may result in rapid resolution of the epididymitis. References 1 : Amiodarone in the treatment of cardial arrhythmias in children. One hundred thirty-five cases. Amer. Heart J.1980; 100: 1063. Google Scholar 2 : Amiodarone treatment of critical arrhythmias in children and young adults. J. Amer. Coll. Cardiol.1984; 4: 749. Google Scholar 3 : Use of amiodarone for short-term and adjuvant therapy in young patients. Amer. J. Cardiol.1991; 68: 603. Google Scholar 4 : Clinical efficacy and safety of intravenous amiodarone in infants and children. Amer. J. Cardiol.1994; 74: 573. Google Scholar 5 : Amiodarone in children: borrowing from the future?. J. Amer. Coll. Cardiol.1990; 15: 1125. Google Scholar 6 : Toxic and therapeutic effects of amiodarone in the treatment of cardiac arrhythmias. J. Amer. Coll. Cardiol.1983; 2: 1114. Google Scholar 7 : Non-infectious epididymitis associated with amiodarone therapy (Letter to the Editor). Lancet1984; 2: 1211. Google Scholar 8 : Amiodarone-associated epididymitis: drug-related epididymitis in the absence of infection. J. Urol.1985; 133: 971. Abstract, Google Scholar 9 : Association of seminal desethylamiodarone concentration and epididymitis with amiodarone treatment. Brit. Med. J.1988; 296: 19. Google Scholar 10 : Amiodarone-induced sterile epididymitis. Urol. Int.1988; 43: 372. Crossref, Medline, Google Scholar 11 : Epididymitis caused by treatment with amiodarone. Genitourin. Med.1989; 65: 257. Google Scholar 12 : Amiodarone-induced epididymitis: report of a new case and literature review of 12 cases. Canad. J. Cardiol.1993; 9: 833. Google Scholar 13 : Epididymitis in infants and boys: underlying urogenital anomalies and efficacy of imaging modalities. J. Urol.1987; 138: 1100. Abstract, Google Scholar 14 : Etiology of acute scrotum in 100 boys with regard to age distribution. J. Urol.1988; 139: 1023. Google Scholar 15 : Acute non-specific epididymitis in boys. A survey based on 48 consecutive cases. Scand. J. Urol. Nephrol.1975; 9: 5. Google Scholar 16 : Ectopic ureter presenting with epididymitis in childhood: report of 5 cases. J. Urol.1985; 134: 131. Link, Google Scholar 17 : Epididymitis in children and adolescents. A 20-year retrospective study. Amer. J. Dis. Child.1987; 141: 41. Google Scholar 18 : Epididymitis in older boys: dysfunctional voiding as an etiology. J. Urol.1995; 154: 762. Link, Google Scholar 19 : Newer antiarrhythmic drugs in children. Amer. Heart J.1987; 113: 179. Google Scholar 20 : Amiodarone in testis and semen (Letter to the Editor). Lancet1985; 1: 341. Google Scholar 21 : Clinical pharmacokinetics and efficacy of amiodarone for refractory tachyarrhythmias. Circulation1983; 67: 1347. Google Scholar 22 : Association of serum desethylamiodarone concentration with adverse effects of amiodarone. Brit. J. Clin. Pharmacol.1984; 18: 276. Google Scholar 23 : Anti-amiodarone antibodies: detection and relationship to the development of side effects. Amer. J. Med.1988; 85: 197. Google Scholar Department of Urology, Children's Hospital, Boston, Massachusetts© 1998 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited bySOMEKH E, GORENSTEIN A and SEROUR F (2018) Acute Epididymitis in Boys:: Evidence of a Post-Infectious EtiologyJournal of Urology, VOL. 171, NO. 1, (391-394), Online publication date: 1-Jan-2004. Volume 160Issue 2August 1998Page: 515-517 Advertisement Copyright & Permissions© 1998 by American Urological Association, Inc.MetricsAuthor Information JOEL HUTCHESON More articles by this author CRAIG A. PETERS More articles by this author DAVID A. DIAMOND (DIAMOND) Requests for reprints: Children's Hospital, 300 Longwood Ave., Boston, Massachusetts 02115. More articles by this author Expand All Advertisement PDF downloadLoading ...

Epididymitis

10.1016/s0022-5347(01)62950-1

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Citations (23)

Initial validation of a virtual-reality robotic simulator

Journal of Robotic Surgery (2008)

Thomas S. Lendvay Pasquale Casale Robert Sweet Craig A. Peters

Work space

10.1007/s11701-008-0099-1

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Citations (58)