Religious pilgrimage, or Hajj, is a basic tenet of the Islamic doctrine. Each year approximately 3 million pilgrims congregate for up to 2 weeks in a <3 square mile area around the city of Makkah. Hajjis can experience physical and emotional stress with limited healthcare access. Cardiovascular events were the main cause of death during Hajj for the last decade; therefore the Strategic Cardiac Hajj Interventional Program(SCHIP) was launched in 2009 to provide improved cardiac outcomes. To assess the impact of SCHIP on cardiac mortality during Hajj. A team of Cardiologists, specialists, nurses with access to three cardiac catherization laboratories provided 24-h-a-day support to 13 local hospitals throughout the Hajj period. Cardiac and all causes mortality adjusting for the potential other covariates were statistically analyzed using time series data before and after intervention. Cardiac death rates during 2006, 2007 and 2008 were 51.7%, 50.6% and 53.2%. After SCHIP introduction rates in 2009, 2010 and 2011 were 27%, 32.5% and 21.5%. The in-hospital mortality for ACS were 4.7%, 4.6% and 3.0%. The number of cardiac procedure performed in 2 weeks during Hajj 2009, 2010, and 2011 were 183, 288 and 550. The majority of the procedure in the last 3 years were coronary catherization 90.1%, 80.9% and 86.7% . The rates of open heart surgery were 7%, 5.2% and 4.5% . After introduction of SCHIP, cardiac and in-hospital mortality substantially reduced. Future introduction of mobile cardiac catherization laboratories may further reduce cardiac mortality.