Ayhan Algül

GATA Haydarpaşa Eğitim Hastanesi

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i-10 index

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Author Order

Document Type

Co-Authors

Cengiz Başoğlu

Istanbul University

Servet Ebrinç

GATA Haydarpaşa Eğitim Hastanesi

MÇ

Mesut Çetin

Queen Mary University of London

Mehmet Alpay Ateş

GATA Haydarpaşa Eğitim Hastanesi

İG

İbrahi̇m Gündoğmuş

Memorial Ankara Hospital

ÜB

Ümit Başar Semiz

İstanbul Sabahattin Zaim Üniversitesi

Alpay Ateş

Karabük University

ÜS

Ü.B. Semiz

Muğla University

Hakan Balıbey

Elazığ Eğitim ve Araştırma Hastanesi

Abdulkadir Karagöz

Haydarpaşa Numune Eğitim ve Araştırma Hastanesi

Cooperative Institutions

Sağlık Bilimleri Üniversitesi

237

Bakırköy Psychiatric Hospital

Istanbul University

Ministry of Health

Marmara University

University of Health Science

Konya Eğitim ve Araştırma Hastanesi

Hacettepe University

Sivas State Hospital

GATA Haydarpaşa Eğitim Hastanesi

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PDW and RDW are new parameters for bipolar episodes and unipolar depression

Psychiatry and Clinical Psychopharmacology (2018)

İbrahi̇m Gündoğmuş Ayhan Algül Abdulkadir Karagöz Murat Kıyançiçek

INTRODUCTION: Bipolar disorder (BD) and unipolar depression (UD) are complex and multifactorial mental disorders characterized by mood swings, disability, and impaired quality of life. In the present study, we researched the roles of inflammatory cells and their value as inflammation markers in BD and UD.OBJECTIVE: Sixty-nine manic, 60 euthymic, and 70 UD patients and 60 sex-matched healthy volunteers (control group) were retrospectively analysed. Platelet (PLT), platelet distribution width (PDW), and red cell distribution width (RDW) levels were measured in four groups. The aim of this study was to evaluate PLT, PDW, and RDW levels patient with UD and two different phases of BD: euthymic and manic.RESULTS: In our study, 199 patients and 60 controls were included. There were no differences between the patients and the healthy control group participants in terms of age and sex. The bipolar episodes and the UD patient group were statistically significantly different from the healthy controls in terms of PLT, PDW, and RDW.CONCLUSION: Our study is the first in the literature to compare blood PLT, PDW, and RDW levels in bipolar episodes, UD patients, and healthy control groups. We believe that the levels of PLT, PDW, and RDW can be used as novel markers of bipolar episodes and UD. More detailed and larger prospective clinical studies are required to confirm these findings.

Depression

10.1080/24750573.2018.1468616

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Citations (10)

Corrigendum: “The Relationship of Smartphone Addiction and Alexithymia”

Psychiatry Investigation (2024)

İbrahim Gündog ̆mus Mehmet Sinan Aydın Ayhan Algül

Smartphone addiction

10.30773/pi.2021.0072e

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Citations (0)

Childhood traumas in patients with bipolar disorder: association with alexithymia and dissociative experiences

Anatolian Journal of Psychiatry (2015)

Onur Yılmaz Mehmet Ateş mit Semiz Recep Tutuncu Yasin Bez

Objective: The number of studies investigating the traumatic events experienced during childhood period in patients with bipolar disorder (BD) are limited and to our knowledge no previous study was conducted about alexithymia and dissociative experiences of these patients as well. Besides investigation of childhood traumas and associated dissociative and alexithymic properties, identification of the differences between BD patients with and without childhood trauma (CT) was aimed in this study. Methods: Among the admissions to the psychiatry outpatient clinic, 70 BD patients and 70 healthy control subjects were included into the study. Structured Clinical Interview for DSM-IV Axis-I Disorders (SCID-I), Dissociative Experiences Scale (DES), Childhood Trauma Questionnaire (CTQ) and Toronto Alexithymia Scale (TAS-20) were administered. Results: Mean subscale and total scores of patients with BD in both CTQ and TAS-20, and mean DES score were found to be significantly higher than healthy control subjects. Psychopathological acts, number of episodes and suicide attempts were higher in the BD patients with childhood trauma history than that of the BD patients without any history of childhood trauma. Additionally, positive correlations were found between ‘sexual abuse’ and alexithymia total score along with ‘difficulty identifying feelings’ subscale score. Moreover, mean DES score was also found to be positively correlated with ‘difficulty identifying feelings’ subscale score, ‘difficulty to describe feelings’ subscale score, alexithymia total score, and episode frequency. Conclusion: These results highlight the importance of protective mental health in the treatment of BD and reveal that childhood traumas should be questioned when evaluating patients especially with the diagnosis of BD.

Association (psychology)

10.5455/apd.188358

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Citations (12)

Evaluation of reproductive hormones relations with response to treatment in male patients with first episode psychosis

European Psychiatry (2016)

Alpay Ateş Ibrahim Oner Cengiz Başoğlu Ayhan Algül Recep Tutuncu

Objectives Data regarding schizophrenia treatment has been increasing whereas the information about predictors of treatment response is limited. In this study, our aim is to investigate the serum levels of reproductive hormones as a biological predictor in terms. Methods Thirty-three hospitalized male patients in GATA Haydarpasa Training Hospital with the diagnosis of first episode psychosis were included into the study. The study was prospective and naturalistic in design. The clinical course was recorded by means of Positive and Negative Symptom Scale (PANSS) in pretreatment period, 2nd and 6th weeks of the study. Prolactin, FSH, LH, estrogen, testesterone and oxytocin serum levels were also measured at the same dates. Results Treatment response was assessed as unresponsive when PANSSttl scores were lower than 25%, partial response when PANSSttl scores were between 25%-40% changes, and response when PANSSttl scores were higher than 40%. Patients were grouped according to those cut-off points. There was a significant positive correlation between oxytocin, FSH serum levels and positive symptoms (ρ = 0.437, P = 0.011; r = 0.385, P = 0.027). There was also significant negative correlation between testesterone serum levels and negative and total psychopathology scores ( r = −0.352, P = 0.044; r = −0.429, P = 0.013). It was seen that pretreatment testerone levels had a significant biological marker on predicting remission when the serum levels were lower than 460,91 ng/dL. Conclusions This study shows that hypothalamo-hypophysial-gonadal axis hormones and reproductive hormones, especially testesterone, may be an important biological marker of treatment response prediction in first episode psychosis. Disclosure of interest The authors have not supplied their declaration of competing interest.

10.1016/j.eurpsy.2016.01.608

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Epileptic seizure during anaesthesia induction with etomidate.

PubMed (2010)

Hüseyin Şen Ayhan Algül Mehmet Güney Şenol Alpay Ateş Emre Kılıç

In this report a 20-year-old male patient who had suffered tonic-clonic seizure after a single induction dose of etomidate until a bispectral index value of 60 is presented. Our best knowledge, this case is the first report of pure etomidate (with induction dose) induced generalized tonic clonic seizure proven with EEG. Anaesthesiologists should be careful against such a complication even in the induction stage of anaesthesia during etomidate use.

Etomidate

Bispectral index

Tonic (physiology)

Source

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Citations (7)

TRAVMA SONRASI DİSSOSİYATİF PSİKOZ: OLGU SUNUMU

BOĞAZİÇİ TIP DERGİSİ (2017)

İbrahi̇m Gündoğmuş MUSTAFA İSPİR Osman Bakkal Ayhan Algül

10.15659/bogazicitip.17.10.703

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A Case with Euprolactinemic Galactorrhea Induced by Escitalopram

The International Journal of Psychiatry in Medicine (2007)

Murat Gülsün Ayhan Algül Ümit Başar Semiz Mehmet Alpay Ateş Ali Doruk

Endocrine and reproductive side effects of serotonergic antidepressants are uncommon and galactorrhea is only rarely mentioned among SSRI-related side effects. Perhaps through suppression of dopamine neurotransmission releasing prolactin from tonic inhibitor control of dopamine, serotonin-enhancing antidepressants may result in a rise in prolactin levels. However, we here describe a case of euprolactinemic galactorrhea induced by the SSRI escitalopram and discuss potential mechanisms of action.

Galactorrhea

Escitalopram

10.2190/pm.37.3.d

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Citations (25)

The Reliability and Validity of the Turkish Version of Psychopathy Checklist-Revised (Turkish PCL-R)

Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychopharmacology (2015)

Recep Tutuncu Selim Kılıç Cengiz Başoğlu Mehmet Alpay Ateş Ayhan Algül

Objectives: Psychopathy is a distinct personality organization and differs from antisocial personality disorders in many aspects. Its diagnosis is challenging but also critical to predict criminality. In this context, Psychopathy Checklist Revised (PCL-R) is a useful tool in the diagnosis of psychopathy. Its reliability and validity was shown in various populations but has not been studied in a Turkish population. Our aim was to demonstrate the reliability and validity of PCL-R in a sample from Turkey.Methods: 425 male subjects with antisocial personality disorder and 125 controls without any psychiatric diagnoses were included in the study. DSM-5 diagnostic criteria were used and PCL-R was administered to all participants. The reliability of the Turkish version of PCL-R was determined by test-retest and internal consistency methods. In the ROC analysis performed with PCL-R, DSM-5 criteria were taken as a gold standard, the sensitivity; specificity and cut-off values of PCL-R were estimated. To evaluate the adequacy of the scale construct validity, Exploratory Factor Analysis and Kaiser-Meyer-Olkin (KMO) and Barlett tests were applied. Reproducibility of the test was evaluated by Pearson correlation coefficient. Re-testing was performed with 171 subjects two weeks after the first test.Results: In reliability analysis, the Cronbach's alpha internal consistency coefficient was calculated to be a=0.977. Pearson correlation coefficient of test-retest was r=0.94 (p<.001). Item-total correlations ranged from 0.18 to 0.94. Its sensitivity and specificity was 98.3% and 100.0%, respectively, with a cut-off point of 20. In principal component analysis, two factors had Eigen values greater than 1. These two factors accounted for 76.54% of the variance in PCL-R scores.Conclusions: Turkish PCL-R is a valid and reliable measure of psychopathy to detect psychopathic traits. However, more studies on psychopathy need to be conducted in different Turkish sample groups.

Psychopathy Checklist

Gold standard (test)

Validity

10.5455/bcp.20150310105903

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Citations (6)

Duloxetine-induced ejaculation with defacation: a case report

Anatolian Journal of Psychiatry (2017)

İbrahi̇m Gündoğmuş Mustafa İspir Ayhan Algül Servet Ebrinç

Duloxetine, a serotonin and norepinephrine reuptake inhibitor, is succesfully used for major depressive disorder, generalized anxiety disorder, stress incontinence, diabetic neuropatic pain and fibromyalgia treatment. Most common side effects of duloxetine are nausea, dry mouth, constipation, sleep disorder, dizziness, fatigue, somnolence, tremor. In short time studies of duloxetine suggest that sexual dysfunction occur with duloxetine less than SSRI. Although sexual side effects such as low ibido, orgasm disorder, ejaculation disorder are common side effects of antidepressant drugs, sponton ejaculation is a side effects that occurs rarely. On the other hand both psychiatric disorders and drugs which used psychiatric disorders affect defecation frequency and form in addition it can cause that patients can have some problems in own daily life. In this paper, case of duloxetine-induced ejaculation with defacation is discussed.

Ejaculation

10.5455/apd.247400

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Fractional Anisotropic Changes of Corpus Callosum Associated with Antipsychotic Treatment in First-Episode Antipsychotic Drug-Naive Patients with Schizophrenia

Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychopharmacology (2016)

Erdal Pan Mehmet Alpay Ateş Ayhan Algül Aykut Aytekin Cengiz Başoğlu

Objective: Schizophrenia involves white matter abnormalities that might have a central role in the pathophysiology. Abnormal brain connectivity especially in prefrontal and temporal heteromodal cortex has been suggested as the leading structural impairment in patients with schizophrenia. In this study we examined the relationship between potential white matter changes and clinical response, as well as associations with antipsychotic treatment follow-up.Methods: 18 first-episode schizophrenia (FES) patients were recruited from the outpatient unit of the GATA (Gulhane Military Medical Academy) Haydarpasa Research and Training Hospital, between June 2009-February 2010. Fourteen patients with FES were recruited, and 16 healthy control subjects were recruited from the community. Diffusion tensor MRI (DT-MRI) was obtained from participants at baseline and after 4 weeks of standard antipsychotic treatment. A color-coded fractional anisotropy map for each 11 patient was extracted from the 4-week follow-up and the baseline splenium and genu FA measurements. According to Basser and others major eigenvector linear maps were transformed into the color-coded maps. Differences in Positive and Negative Syndrome Scale (PANSS) scores and Brief Psychiatric Rating Scale (BPRS) scores between baseline and follow up were also evaluated.Results: In this study; in the FES patients, both genu FA (p=0.001) and the splenium FA (p=0.013) values were statistically significantly lower than the healthy control group. There were mild FA increases respectively genu and splenium (p=0.533, p=0.318) in the FES patients after the treatment. But the FA changes did not correlate with the changes in clinical symptoms. A negative, moderate, statistically significant correlation (Pearson's r=-0.569, p=0.034) was found between baseline splenium FA values and BPRS scores. The duration of illness prior to treatment was negatively, weak, statistically non-significantly correlated (r=-0.066; p=0.846) between baseline and follow-up splenium FA changes.Conclusions: The reduced mean Callosal FA (CFA) values might indicate myelination defects and problems in axonal transport. The existence of white matter changes even in first episode drug-naive schizophrenia patients supports the view that these problems occurs in earlier stages of development. Although the callosal FA changes did not correlate with symptom improvement or the dose of antipsychotic medication, there was a mild increase in follow-up FA measurements. These findings show that CC which is the main conduit of interhemispheric connection is affected distinctly in patients with schizophrenia. Further collaborative studies are needed to clarify the potential long-term effects of antipsychotics on white matter microstructure and also its reversibility.

Splenium

Amisulpride

10.5455/bcp.20160319021659

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Citations (1)