Evaluation of reproductive hormones relations with response to treatment in male patients with first episode psychosis
0
Citation
0
Reference
10
Related Paper
Abstract:
Objectives Data regarding schizophrenia treatment has been increasing whereas the information about predictors of treatment response is limited. In this study, our aim is to investigate the serum levels of reproductive hormones as a biological predictor in terms. Methods Thirty-three hospitalized male patients in GATA Haydarpasa Training Hospital with the diagnosis of first episode psychosis were included into the study. The study was prospective and naturalistic in design. The clinical course was recorded by means of Positive and Negative Symptom Scale (PANSS) in pretreatment period, 2nd and 6th weeks of the study. Prolactin, FSH, LH, estrogen, testesterone and oxytocin serum levels were also measured at the same dates. Results Treatment response was assessed as unresponsive when PANSSttl scores were lower than 25%, partial response when PANSSttl scores were between 25%-40% changes, and response when PANSSttl scores were higher than 40%. Patients were grouped according to those cut-off points. There was a significant positive correlation between oxytocin, FSH serum levels and positive symptoms (ρ = 0.437, P = 0.011; r = 0.385, P = 0.027). There was also significant negative correlation between testesterone serum levels and negative and total psychopathology scores ( r = −0.352, P = 0.044; r = −0.429, P = 0.013). It was seen that pretreatment testerone levels had a significant biological marker on predicting remission when the serum levels were lower than 460,91 ng/dL. Conclusions This study shows that hypothalamo-hypophysial-gonadal axis hormones and reproductive hormones, especially testesterone, may be an important biological marker of treatment response prediction in first episode psychosis. Disclosure of interest The authors have not supplied their declaration of competing interest.1986년 1월부터 1986년 3월까지 이화대학병원에 입원한 합병증이 없는 무진통의 만삭 임부 41예에 대하여 oxytocin자극전 모체혈청 prolactin치와 oxytocin으로 15∼20분(11예), 25∼30분(11예), 35∼45분(6예) 및 50분(13예) 동안 규칙적인 자궁수축을 유발, 자극시킨 후 모체혈청 prolactin치를 측정하고 곧 제왕절개술로 분만하여 태아제대혈청 prolactin치를 측정하였다. 대조군으로 무진통의 만삭 임부 6예에 대하여 oxytocin자극없이 모체혈청 prolactin치를 측정하고 곧 제왕절개술로 분만하여 다음과 같은 결론을 얻었다. 1. Oxytocin자극후의 평균 모체혈청 prolactin치는 그 자극전의 평균치에 비하여 통계학적 차이는 없었으나, 자극 50분 후의 평균 모체혈청 prolactin치는 상승하는 경향이 있었다. Oxytocin자극후에 모체혈청 prolactin치가 증가한 예의 빈도는 그 자극 시간을 증가시킬수록 자극전에 비하여 점진적으로 더 증가하는 경향을 보였다. 2. Oxytocin자극후 제왕절개술로 분만된 태아의 평균제대혈청 prolactin치의 변화에 있어서 15∼20분간 및 25∼30분간 자극군에서 각각 273.8±24.7ng/ml, 248.0±25.4ng/ml으로 oxytocin자극없이 제왕절개분만된 태아의 평균 prolactin치(280.5±26.4ng/ml)에 비하여 거의 차이가 없었으나, 35∼45분간 및 50분간 자극군에서는 각각 339.0±47.7ng/ml, 339.1±44.6ng/ml로서 oxytocin자극없이 분만된 평균 제대혈청 prolactin치에 비하여 각각 20.9%가 증가되었다. 모체측 및 태아측 평균 혈청 prolactin치 비의 변화에 있어서 자극시간을 35분 또는 그 이상으로 증가시켰을 때에 태아측 평균 제대혈청 oxytocin치가 모측형성 평균 prolactin치에 비하여 더 증가하는 경향이 있었다(1:1.1:, 1:1.2).
Prolactin cell
Cite
Citations (0)
Oxytocin plays an important role in social behavior. Thus, there has been significant research interest for the role of the oxytocin system in several psychiatric disorders, and the potential of intranasal oxytocin administration to treat social dysfunction. Measurement of oxytocin concentrations in saliva are sometimes used to approximate peripheral levels of oxytocin; however, the validity of this approach is unclear. In this study, saliva and plasma oxytocin was assessed after two doses of Exhalation Delivery System delivered intranasal oxytocin (8IU and 24IU), intravenous oxytocin (1IU) and placebo in a double-dummy, within-subjects design with men. We found that intranasal oxytocin (8IU and 24IU) administration increased saliva oxytocin concentrations in comparison to saliva oxytocin concentration levels after intravenous and placebo administration. Additionally, we found that saliva oxytocin concentrations were not significantly associated with plasma oxytocin concentrations after either intranasal or intravenous oxytocin administration. Altogether, we suggest that saliva oxytocin concentrations do not accurately index peripheral oxytocin after intranasal or intravenous oxytocin administration, at least in men. The data indicates that elevated oxytocin saliva levels after nasal delivery primarily reflect exogenous administered oxytocin that is cleared from the nasal cavity to the oropharynx, and is therefore a weak surrogate for peripheral blood measurements.
Cite
Citations (2)
Cite
Citations (4)
Department of Physiology, Middlesex Hospital Medical School, London W1P 6DB, and *Institut für Physiologie, Technische Universität München-Weihenstephan, West Germany (Received 6 August 1974) The release of both prolactin and oxytocin during lactation and machine milking in the cow is well established. Benson & Folley (1956) first suggested that oxytocin might initiate the release of prolactin. Bryant & Greenwood (1968), using a specific immunoassay for prolactin, were able to demonstrate this relationship. However, subsequent workers (Koprowski & Tucker, 1971; Schams, 1972) using exogenous oxytocin were unable to confirm these observations. Experiments involving the use of exogenous oxytocin are inconclusive as it may not be possible to produce appropriate concentrations of oxytocin in the portal vessels to the hypophysis. Observations, therefore, were made on plasma samples taken frequently during milking and teat stimulation to elucidate the relationship between oxytocin and prolactin release. Release of the second neurohypophysial hormone, arginine-vasopressin (AVP), was also
Milking
Cite
Citations (11)
l982년 6윌부터 9월까지 약 4개월간 연세대학교 의과대학부속 원주기독병원 산부인과에 분만하기 위하여 입원한 건강한 산모중에서 분만된 건강한 신생아 100예를 대상으로 하여 oxytocin 주입군 50예(유도분만 25예와 촉진분만 25예) 와 대조군 50예(자연분만 25예와 선택적제왕절개슬 25예)로 나누어 oxytocin 주입분만이 신생아혈청담적소치에 미치는 영향 및 과담적소혈증 발생정도를 연구하기 위해 생후즉시 제대혈액 및 생후 36~60시간에 신생아혈액을 채취하여 혈청 담적소치를 비교하였고 나아가서 그기전을 설명하기 위하여 혈청 나트륨, 혈색소, 헤마토크리트. 적혈구수를 측정하였고 oxytocin의 주입용량, 주입시간과의 관계를 조사분석하여 다음과 같은 결론을 얻었다. 연구결과를 요약하면 다음과 같다. 1. 혈청담적소치가 oxytocin 주입군의 제대혈액 및 신생아혈액에서 의의있게 증가하였다. 2. 과담적소혈증은 oxytocin 주입군 50예중의 4예 (8%) 예서만 발생하였다 3. oxytocin 주입용량이 증가함에 따라 제대혈액 및 신생아혈액에서 헐청담적소시가 증가하였으며 전체 oxytocin 주입용량이 5 unit 이상인 경우 의미있는 혈청 담적소치의 증가를 보였다. 4. oxytocin 주입시 간이 증가함에 따라 제대혈액 및 신생아혈액에서 혈청 담적소치가 증가하였다. 5. oxytocin 주입군의 제대혈액에서 혈색소, 혜마토크리트, 적혈구수가 증가이는 양상을 보였으며 혈청나트륨치는 변화가 없었다. 이상의 결과로 보아 oxytocin 주입분만시신생아 혈청 담적소치가 증가하였고 증가된 혈청담적소치는 oxytocin 주입용량과 시간에 비례하는 것으로 사료되었다.
Oxytocin receptor
Cite
Citations (0)
The disappearance of phe 3 ‐oxytocin, val 3 ‐oxytocin and oxytocin from the circulation of male rats was shown to be due to qualitatively similar mechanisms, that is, it depends on uptake in the kidneys and organs of the splanchnic vascular area. However, compared to phe 3 ‐oxytocin and oxytocin (whose half‐lives were essentially similar) val 3 ‐oxytocin took twice as long to reach half its initial blood concentration. In lactating rats the mammary glands probably participated in the uptake of phe 3 ‐oxytocin, but the rate of disappearance of val 3 ‐oxytocin was not different from that in non‐lactating animals. In male nephrectomized rats without splanchnic circulation, phe 3 ‐oxytocin, unlike val 3 ‐oxytocin, was quickly distributed in a volume equal to two‐thirds of the total body water. Using oxytocin as the standard, val 3 ‐oxytocin and phe 3 ‐oxytocin were more potent when assayed on a superfused uterus or on a rat uterus in vivo than when assayed by the pharmacopoeial method (1958) on the isolated uterus in an organ bath. The difficulties of assaying oxytocin analogues against oxytocin (or the international standard preparation) are discussed.
Oxytocin receptor
Cite
Citations (9)
The ability of [1-L-pcnicillamine]oxytocin and [1-β-mercapto-β,β-diethyl-propionic acid]oxytocin to suppress the contractions induced by oxytocin in the uteri of 12- to 16-day-pregnant rats has been demonstrated, using a new technique for recording uterine activity in vivo.
Cite
Citations (12)
Oxytocin receptor
Cite
Citations (12)
Cite
Citations (42)
An attempt was made to separate estrogen from prolactin dependency of 7,12-dimethylbenz(a)anthracene (DMBA)-induced rat mammary tumors at 2.5 and 5 months after DMBA injection. Ovariectomy and drug and/or hormone treatments were used to produce an estrogen or prolactin deficiency for 2 weeks, followed by a 2-week period in which the deficiency was corrected. Tumors were classified as estrogen or prolactin dependent based upon regression in the absence of the hormone and resumption of growth upon hormone replacement. At 2.5 months and 5 months after DMBA injection, about 29 and 33% of the tumors, respectively, were classified as prolactin dependent, and 35 and 45%, respectively, were classified as estrogen dependent. However, the percentage of estrogen-dependent tumors was reduced to 2.2 and 9.7%, respectively, when prolactin levels were maintained after ovarierctomy. These results indicate that most DMBA-induced mammary tumors in Sprague-Dawley female rats are dependent on both estrogen and prolactin but that ovariectomy or estrogen administration do not accurately reflect estrogen dependency, since prolactin secretion also is altered by these procedures.
Prolactin cell
7,12-Dimethylbenz[a]anthracene
Cite
Citations (55)