Objective: Microalbuminuria (MA) is known to predict the onset of clinical proteinuria and chronic renal failure in diabetes mellitus. More recently, MA has been found to be an independent risk factor for cardiovascular disease in non diabetic populations. The present study was designed to investigate the prevalence of microalbuminuria and factors that associate with urine excretion of albumin in the population of Blida. Design and method: 2920 Participants in our specialized consultation were enrolled in this study. Besides the routine checkup program (an interview regarding health status, physical examination, chest X-ray, electrocardiography, and laboratory assessment of cardiovascular risk factors). For MA, spot urine samples were collected in the early morning and microalbuminuria was defined as, a urinary albumin excretion between 30 and 300 mg/l. These patients also underwent determination of ambulatory blood pressure monitoring. All calculations and statistical analyzes are processed by the SPSS 17.0. Results: The prevalence of MA in hypertensive population was 32%.The blood pressure of participants was 138 ± 16/78 ± 13 mmHg and 39.8% and 14.1% of participants were with hypertension and diabetes mellitus, respectively. Urine albumin was detected in 40.1% of cases. Mean age of 59.71 ± 13.56 years. Body mass index was > 30 kg/m2 in 58.2% of cases. Prevalence of Hyperglycemia was 23% with MA> 30 mg/l. Multivariate regression analysis revealed that abnormal albuminuria was correlated with systolic blood pressure, estimated 24 hours urinary salt excretion, and fasting plasma glucose after adjustment for possible factors (p < 0.0001). Conclusions: The prevalence of microalbuminuria increases with increase in age, body mass index and duration of hypertension. From this study, it is conceived that MA can be used as a predictor of future cardiovascular events in hypertensive patients.
Objective: The objective of this study was to evaluate the association between hypertension and other cardiovascular risk factors in elderly patients Design and method: We included 587 patients in the study (45% males and 55% females), with a mean age of 69.11 ± 10.60 years with essential arterial hypertension, examined between January 2013-june 2014 in specialized consultation in the area of Blida (Algeria). All subjects were interviewed with special questionnaire about lifestyle factors and medical history. Blood pressure (BP) and anthropometry were performed. Hypertension (HTN) was diagnosed according to elevation BP over 150 and/or over 90 mm Hg. Lipid profile (total cholesterol, triglycerides, HDL and LDL cholesterol), and fasting blood sugar measurement. The cardiovascular risk profile we evaluated considering clinical historyAll calculations and statistical analyzes are processed by the SPSS 17.0. Results: The mean blood pressure of participants was 151 ± 14/89 ± 11 mmHg. The most frequent associated risk factors were diabetes mellitus in 61.1% of the patients, obesity in 54.6% of the patients, metabolic syndrome in 32.5% of the patients, hypercholesterolemia > 2 g/l in 26.5% of the patients, smoking in 22.7% of the patients, history of coronary artery disease in 36.5% of the patients, stroke history in 19.5% of the patients, heart failure in 9.1% of the patients and renal failure in 6.7% of the patients. 52.9% of the patients had a very high cardiovascular risk profile. 78% of the patients received a combination of antihypertensive drugs. Under therapy, stable values of blood pressure were obtained in 29.2% of the patients. Conclusions: The study showed that elderly patients with both arterial hypertension and diabetes mellitus had higher blood pressure values compared with others risk factors. It is very important to assess the cardiovascular risk profile in elderly hypertensive patients, considering the multiple cardiovascular risk factors for a proper treatment and strategy of the hospitalized elderly.
