Linlin Jiang

Zhejiang Lab

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Yanyan Sun

Ministry of Agriculture and Rural Affairs

Adamu Mani Isa

Chinese Academy of Agricultural Sciences

Hui Ma

Chinese Academy of Agricultural Sciences

Pingzhuang Ge

Chinese Academy of Agricultural Sciences

Aixin Ni

Chinese Academy of Agricultural Sciences

Jilan Chen

Chinese Academy of Agricultural Sciences

Panlin Wang

Chinese Academy of Agricultural Sciences

Yunlei Li

Chinese Academy of Agricultural Sciences

Minhui Li

Hefei Normal University

Yuting Kang

Chinese Academy of Medical Sciences & Peking Union Medical College

Cooperative Institutions

Chinese Academy of Medical Sciences & Peking Union Medical College

Chinese Academy of Sciences

Shanghai Jiao Tong University

Sun Yat-sen University

Chinese Academy of Agricultural Sciences

Ministry of Agriculture and Rural Affairs

Sichuan University

Zhejiang University

Huazhong University of Science and Technology

University of Chinese Academy of Sciences

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Could semiquantitative analysis of real-time ultrasound elastography distinguish more liver parenchyma alterations of nonalcoholic fatty liver disease in patients with polycystic ovary syndrome?

Figshare (2019)

Na Di Xinchuan Zhou Yaxiao Chen Xiaomiao Zhao Lin Li

ABSTRACT Objective: Nonalcoholic fatty liver disease is the commonest diffuse liver disease, of which women with polycystic ovary syndrome are at an increased risk. The aim of the present study was to assess the diagnostic value of the semiquantitative strain parameters of real-time ultrasound elastography for nonalcoholic fatty liver disease in patients with polycystic ovary syndrome. Subjects and methods: Thirty-five polycystic ovary syndrome patients with nonalcoholic fatty liver disease, 70 polycystic ovary syndrome patients without nonalcoholic fatty liver disease, and 70 healthy female controls of reproductive age were included. All participants underwent ultrasonic examination and semiquantitative analysis of real-time ultrasound elastography of the liver. Results: Main semi quantitative strain parameters, such as average strain value, differed significantly among groups polycystic ovary syndrome with nonalcoholic fatty liver disease, polycystic ovary syndrome without nonalcoholic fatty liver disease, and control (87.02 ± 10.16 vs. 96.31 ± 11.44 vs. 104.49 ± 7.28, p < 0.001). Clinical and laboratory parameters differed significantly between the two subgroups with low or high average strain value. For diagnostic value of average strain value for elevated aminotransferase, the area under the curve was 0.808 (range 0.721-0.895). In multiple linear regression analysis, polycystic ovary syndrome, waist circumference, and metabolic syndrome were stand-alone independent factors associated with average strain value among subjects without nonalcoholic fatty liver disease. Conclusion: Semiquantitative real-time ultrasound elastography analysis could distinguish liver parenchyma alterations in patients with polycystic ovary syndrome more sensitively. The diagnostic value of the proposed method for nonalcoholic fatty liver disease need further research.

Parenchyma

Liver parenchyma

10.6084/m9.figshare.7898492

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Prolaction gene association with chicken egg production traits

The Indian Journal of Animal Sciences (2019)

Jing Fan Linlin Jiang Xiaohui Liu WEI-FENG ZHANG Bin Wang

In this study, using the direct sequencing technology, 6 SNPs were identified in PRL gene, among which, 3 SNPs were present in coding region and 3 in 3â€™UTR. Mutations in coding region did not change the protein sequences. SNPs g.4603, g.8823 and g.8885 were utilized for association test with AFE, EN 300 and EN 500. SNP g.4603 was associated with EN 300, whereas the SNP g.8823 was significantly associated with EN 300. These two SNPs in PRL gene could be used as the potential molecular markers for egg production traits selection in Taihang chicken.

SNP

Coding region

Genetic Association

10.56093/ijans.v89i2.87345

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Identification of microRNA-Associated-ceRNA Networks Regulating Crop Milk Production in Pigeon (Columba livia)

Genes (2020)

Pingzhuang Ge Hui Ma Yunlei Li Aixin Ni Adamu Mani Isa

Pigeon belongs to altrices. Squab cannot forage independently. Nutrition can only be obtained from crop milk secreted by male and female pigeon. miRNA could regulate many biological events. However, the roles of miRNA and ceRNA in regulating crop milk production are still unknown. In this study, we investigated the miRNAs expression profile of female pigeon crop, explored the potential key genes, and found the regulatory mechanisms of crop milk production. A total of 71 miRNAs were identified differentially expressed significantly. Meanwhile, miR-20b-5p, miR-146b-5p, miR-21-5p, and miR-26b-5p were found to be the key miRNAs regulating lactation. Target genes of these miRNAs participated mainly in cell development; protein and lipid synthesis; and ion signaling processes, such as cell-cell adhesion, epithelial cell morphogenesis, calcium signaling pathway, protein digestion, and absorption. In the ceRNA network, miR-193-5p was located in the central position, and miR-193-5p/CREBRF/LOC110355588, miR-460b-5p/GRHL2/MSTRG.132954, and miR-193-5p/PIK3CD/LOC110355588 regulatory axes were believed to affect lactation. Collectively, our findings enriched the miRNA expression profile of pigeon and provided novel insights into the microRNA-associated-ceRNA networks regulating crop milk production in pigeon.

Competing Endogenous RNA

10.3390/genes12010039

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Asymmetric expression of CA2 and CA13 linked to calcification in the bilateral mandibular condyles cause crossed beaks in chickens

Journal of Integrative Agriculture (2023)

Lei Shi Yanyan Sun Yunlei Li Hao Bai Jingwei Yuan

Crossed beak is a complex mode of inheritance with prevalence ranging from 0.2% to 7.4% in at least 12 chicken strains worldwide. To reveal the intrinsic factors causing crossed beaks, genes expression patterns in bilateral mandibular condyle between affected and normal birds were characterized by RNA sequencing analysis in the present studies. Crossed beak was induced by short length of unilateral mandibular ramus, and a total of 110 differentially expressed genes were up- or down-regulated in the affected (short) mandibular condyle side as compared to the normal side. Carbonic anhydrase 2 (CA2) and Carbonic anhydrase 13 (CA13) were enriched in the carbonate dehydratase activity, and high-expressed in mandibular condyle and osteoblasts (P < 0.05). However, both were low-expressed in short mandibular condyle side of affected birds (P < 0.05). The carbonate dehydratase inhibitor experiments confirmed that there is positive association between the calcification and carbonic anhydrase isoenzymes. Quantitative analysis with cetylpyridinium chloride showed a decrease in calcification when the cells were transfected with an anti-CA13 shRNA. Our research suggested that CA2 and CA13 are down-calcified in short-side mandibular condyle, and caused mandibular ramus to grow slowly. CA2 and CA13 have the critical role in crossed beaks by regulating calcification of mandibular condyle.

10.1016/j.jia.2023.04.014

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A new way to reduce ICI of OFDM system with precoding

International Conference on Communications, Circuits and Systems (2007)

Linlin Jiang Xianzhong Xie

In this paper we groped for the feasibility about ICI decreasing in precoding OFDM system. First, a model of precoding OFDM system was introduced, then, we present the algorithm of the precoding matrix, Through simulation and analysis, we get the ICI of OFDM system with precoding is reduced, otherwise, the complexity of the receiver does not increase, so the method adapts to the downlink especially.

Zero-forcing precoding

10.1109/icccas.2007.6250056

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Monochromatic green light stimulation during incubation shortened the hatching time via pineal function in White Leghorn eggs

Research Square (Research Square) (2020)

Panlin Wang Yanyan Sun Yunlei Li Jing Fan Yunhe Zong

Abstract Background: Effect of monochromatic green light illumination on embryo development has been reported in chickens. The avian pineal gland is an important photo-endocrine organ formed by a mediodorsal protrusion during embryonic development. However, the involvement of pineal gland in the light transduction process remains to be elucidated. In the present study, we investigated the influence of monochromatic green light on hatching time and explored the possible mechanism via pineal function. Results : A total of 600 eggs of White Leghorn (Shaver strain) were incubated under photoperiods of either 12 h of light and 12 h of darkness using monochromatic green light (12L:12D group) or 24 h of darkness (0L:24D group) for 18 d. Compared to 0L:24D group, the green light stimulation shortened the hatching time without extending the hatch window or impairing hatchability. The liver of embryos incubated in the 12L:12D light condition was heavier than those of the 0L:24D group on d 21 post incubation which may be linked to the observed increase in the serum concentration of insulin-like growth factor 1 (IGF-1); primary secretion of the liver. Histological structure analysis of pineal gland demonstrated that the light stimulation increased follicle area, wall thickness and lumen area on d 10 and d 12 post incubation. Rhythmic function analysis demonstrated that three clock related genes (brain and muscle ARNT-like-1, BMAL1 ; circadian locomotor output cycles kaput, CLOCK ; and cryptochrome-1, CRY1 ) and a melatonin rate-limiting enzyme related gene (Arylalkylamine N-acetyltransferase, AANAT ) were rhythmically expressed in the pineal gland of the 12L:12D group, but not in the 0L:24D group. Simultaneously, the light stimulation also increased the concentration of melatonin (MT), which was linked to hepatocyte proliferation and IGF-1 secretion in previous studies. Conclusions : The 12L:12D monochromatic green light stimulation during incubation shortened hatching time without impairing hatching performance. Pineal gland’s early histological development and maturation of its rhythmic function were accelerated by the light stimulation. It may be the key organ in the photo-endocrine axis that regulates embryo development, and the potential mechanism could be through enhanced secretion of MT in the 12L:12D group which promotes the secretion of IGF-1.

Darkness

10.21203/rs.3.rs-37386/v3

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TsMIP6 enhances the tolerance of transgenic rice to salt stress and interacts with target proteins

Journal of Plant Biology (2015)

Linlin Sun Guohong Yu Xiaori Han Shichao Xin Xiaojing Qiang

Genetically modified rice

Osmotic shock

Ectopic expression

Subfamily

Osmoregulation

Plant cell

Heterologous expression

10.1007/s12374-015-0069-x

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Citations (12)

Monochromatic Green Light Stimulation During Incubation Shortened the Hatching Time via Pineal Function in White Leghorn Eggs

Research Square (Research Square) (2020)

Panlin Wang Yanyan Sun Jing Fan Yunhe Zong Adamu Mani Isa

Abstract Background: Effect of monochromatic green light illumination on embryo development has been reported in chickens. The avian pineal is an important photo-endocrine organ formed by a mediodorsal protrusion of the rudiment during embryonic development. However, the involvement of pineal gland in the lighting transducing process remain to beelucidated.In the present study, we investigated the influence of monochromatic green light on hatching time and explored the possible mechanism via pineal function. Results : A total of 600 eggs were incubated underphotoperiods of either 12 h of light and 12 h of darkness using monochromatic green light (12L:12D group) or 24 h of darkness (0L:24D group)for 18 d, with two replicates for each treatment. As compared to 0L:24D group, the green light stimulation shortened the hatching time without extending the hatch window or impairing hatchability. The liver of embryos incubated in the 12L:12D light condition was heavier than those of the 0L:24D group on d 21 post incubation. Meanwhile, the green light increased the serum concentration of insulin-like growth factor 1 (IGF-1), which is primarily secreted by the liver. Histological structure analysis of pineal gland demonstrated that the light stimulation increased follicle area, wall thickness and lumen area on d 10 and d 12 post incubation. Rhythmic function analysis demonstrated that three clock related genes ( brain and muscle ARNT-like-1 , BMAL1 ; circadian locomotor output cycles kaput , CLOCK ; and cryptochrome-1 , CRY1 ) and a melatonin rate-limiting enzyme related gene ( Arylalkylamine N-acetyltransferase , AANAT ) were rhythmically expressed in the pineal gland of the 12L:12D group, but not in that of the 0L:24D group. Simultaneously, the light stimulation also increased the concentration of melatonin (MT), which was linked to hepatocyte proliferation and IGF-1 secretion in previous studies. Conclusions : The 12L:12D monochromatic green light stimulation during incubation shortened hatching time without impairing hatching performance. Pineal gland’s early histological development and maturation of its rhythmic function were accelerated by the light stimulation. It may be the key organ in the photo-endocrine axis that regulates embryo development, and the potential mechanism could be that its higher secretion product of MT in the 12L:12D group promotes the secretion of IGF-1.

Darkness

Green-light

Light Cycle

10.21203/rs.3.rs-37386/v1

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Hypoxia/reoxygenation-induced mitochondrial dysfunction and autophagy level in H9c2 Cells.

Chen Dongling Zhe Jin Jingjing Zhang Linlin Jiang Chen Kai

Hypoxia

10.1371/journal.pone.0153587.g002

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