Beatriz Pelaz

Center for Research in Molecular Medicine and Chronic Diseases

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Pablo del Pino

Center for Research in Molecular Medicine and Chronic Diseases

Wolfgang J. Parak

Universität Hamburg

Ester Polo

Universidade de Santiago de Compostela

Mahmoud G. Soliman

Royal College of Surgeons in Ireland

Jesús M. de la Fuente

Universidad de Zaragoza

Karsten Kantner

Philipps University of Marburg

Neus Feliu

Universität Hamburg

Carolina Carrillo‐Carrión

Universidad de Sevilla

Daniel Valdepérez

Philipps University of Marburg

Pablo Taboada

Universidade de Santiago de Compostela

Cooperative Institutions

Universidade de Santiago de Compostela

Philipps University of Marburg

Centre National de la Recherche Scientifique

Instituto de Investigación Sanitaria de Santiago

Center for Research in Molecular Medicine and Chronic Diseases

Consejo Superior de Investigaciones Científicas

Universidad de Zaragoza

Chinese Academy of Sciences

Instituto de Salud Carlos III

University of Florida

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Colloidal stability of polymer coated zwitterionic Au nanoparticles in biological media

Inorganica Chimica Acta (2022)

Daniel Valdepérez Nicole Wutke Lisa‐Maria Ackermann Wolfgang J. Parak Markus Klapper

Zeta potential

Bovine serum albumin

Surface charge

Dispersion stability

Hydrophobic effect

10.1016/j.ica.2022.120820

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Citations (11)

Engineering biofunctional magnetic nanoparticles for biotechnological applications

Nanoscale (2010)

María Moros Beatriz Pelaz Pilar López‐Larrubia Maria Luisa García‐Martín Valeria Grazú

Synthesis and characterization of magnetic nanoparticles with excellent size control are showed here. Their functionalization using an amphiphilic polymer is also described. This strategy allows the stabilization of magnetic nanoparticles in aqueous solvents and in addition, the polymer shell serves as a platform to incorporate relevant biomolecules, such as poly(ethylene glycol) and a number of carbohydrates. Nanoparticles functionalized with carbohydrates show the ability to avoid unspecific interactions between proteins present in the working medium and the nanoparticles, so can be used as an alternative to poly(ethylene glycol) molecules. Results confirm these nanoparticles as excellent contrast agents for magnetic resonance imaging. Changes in the spin–spin transversal relaxation times of the surrounding water protons due to nanoparticle aggregation demonstrates the bioactivity of these nanoparticles functionalized with carbohydrates. To finish with, nanoparticle toxicity is evaluated by means of MTT assay. The obtained results clearly indicate that these nanoparticles are excellent candidates for their further application in nanomedicine or nanobiotechnology.

Biomolecule

Nanobiotechnology

10.1039/c0nr00104j

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Citations (103)

Metal ions in the context of nanoparticles toward biological applications

Current Opinion in Chemical Engineering (2014)

Carolina Carrillo‐Carrión Moritz Nazarenus Sara Sánchez Paradinas Susana Carregal‐Romero María Jesús Almendral

10.1016/j.coche.2013.11.006

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Citations (32)

Dissecting common and divergent molecular pathways elicited by CdSe/ZnS quantum dots in freshwater and marine sentinel invertebrates

Figshare (2017)

Alfredo Ambrosone Modi Roopin Beatriz Pelaz Abuelmagd M. Abdelmonem Lisa‐Maria Ackermann

Water ecosystems represent main targets of unintentional contamination of nanomaterials, due to industrial waste or other anthropogenic activities. Nanoparticle insult to living organisms may occur in a sequential way, first by chemical interactions of the material with the target membrane, then by progressive internalisation and interaction with cellular structures and organelles. These events trigger a signal transduction, through which cells modulate molecular pathway in order to respond and survive to the external elicitation. Therefore, the analysis of the global changes of the molecular machinery, possibly induced in an organism upon exposure to a given nanomaterial, may provide unique clues for proper and exhaustive risk assessment. Here, we tested the impact of core/shell CdSe/ZnS QDs coated by a positively charged polymer on two aquatic species, the polyp Hydra vulgaris and the coral S. pistillata, representative of freshwater and sea habitats, respectively. By using reliable approaches based on animal behaviour and physiology together with a whole transcriptomic profiling, we determined several toxicity endpoints. Despite the difference in the efficiency of uptake, both species were severely affected by QD treatment, resulting in dramatic morphological damages and tissue bleaching. Global transcriptional changes were also detected in both organisms, but presenting different temporal dynamics, suggesting both common and divergent functional responses in the two sentinel organisms. Due to the striking conservation of structure and genomic organisation among animals throughout evolution, our expression profiling offers new clues to identify novel molecular markers and pathways for comparative transcriptomics of nanotoxicity.

Marine invertebrates

10.6084/m9.figshare.4836887

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In depth characterisation of the biomolecular coronas of polymer coated inorganic nanoparticles with differential centrifugal sedimentation

Scientific Reports (2021)

André Perez‐Potti Hender López Beatriz Pelaz Abuelmagd M. Abdelmonem Mahmoud G. Soliman

Abstract Advances in nanofabrication methods have enabled the tailoring of new strategies towards the controlled production of nanoparticles with attractive applications in healthcare. In many cases, their characterisation remains a big challenge, particularly for small-sized functional nanoparticles of 5 nm diameter or smaller, where current particle sizing techniques struggle to provide the required sensitivity and accuracy. There is a clear need for the development of new reliable characterisation approaches for the physico-chemical characterisation of nanoparticles with significant accuracy, particularly for the analysis of the particles in the presence of complex biological fluids. Herein, we show that the Differential Centrifugal Sedimentation can be utilised as a high-precision tool for the reliable characterisation of functional nanoparticles of different materials. We report a method to correlate the sedimentation shift with the polymer and biomolecule adsorption on the nanoparticle surface, validating the developed core–shell model. We also highlight its limit when measuring nanoparticles of smaller size and the need to use several complementary methods when characterising nanoparticle corona complexes.

Sedimentation

Biomolecule

Centrifuge

Particle (ecology)

10.1038/s41598-021-84029-8

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Citations (25)

The effect of static magnetic fields and tat peptides on cellular and nuclear uptake of magnetic nanoparticles

Biomaterials (2010)

Carol‐Anne Smith Jesús M. de la Fuente Beatriz Pelaz Edward P. Furlani Margaret Mullin

10.1016/j.biomaterials.2010.01.096

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Citations (74)

無機ナノ粒子周辺の高分子シェル上の可能な酵素分解の研究【JST・京大機械翻訳】

International Journal of Molecular Sciences (Web) (2019)

Zhu Lin Beatriz Pelaz Indranath Chakraborty J Parak Wolfgang

Source

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Inorganic Core–Shell Nanoparticles

Elsevier eBooks (2015)

Stefan Kudera Lisa Maus Marco Zanella Beatriz Pelaz Q. Zhang

Superparamagnetism

Particle (ecology)

10.1016/b978-0-12-803581-8.00581-6

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Citations (2)

Efficient colloidal nanocarriers

Beatriz Pelaz

Nanocarriers

10.29363/nanoge.amamed.2022.014

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Tracking Stem Cells and Macrophages with Gold and Iron Oxide Nanoparticles-the Choice of the Best Suited Particles

Xing Sun Mahmoud Gamal Philipp Nold Alaa Hassan Said Indranath Chakraborty

Nanoparticle (NP)-based cell imaging offers good potential for future diagnosis tools in medicine. Gold and iron oxide NPs can be used as contrast agents for imaging by computed tomography (CT) and magnetic resonance imaging (MRI), respectively. Thus, also cells which have been labeled with these NPs may be tracked. This may be important for in vivo tracking of administered or transplanted cells. In this work, we optimized the conditions to label stem cells and macrophages with a library of gold and iron oxide NPs of different sizes (5-100 nm core diameter) and shapes. We investigated the amount of NPs which can be delivered to different cells, as well as their related toxic effects, in relation to the physicochemical properties of the NPs. Our study revealed that in general, when cells are exposed to NPs at similar elemental concentration (e.g., Au or Fe), bigger NPs lead to higher internalized elemental amounts as compared to exposure with smaller sized NPs. While the exposure concentrations are limited concerning the onset of toxicity, bigger NPs lead to better labeling than small NPs, resulting in improved contrast for imaging with enhanced biocompatibility.

Iron oxide nanoparticles

Tracking (education)

10.1201/9781003306498-36

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