Objective:To report and compare the hematological and serum biochemical profile of goal and sheep from Rahim Yar Khan district in Southern Punjab.Methods:One hundred and twenty blood samples(98 goat and 22 sheep) were collected and their blood glucose, hemoglobin and serum biochemical parameters,cholesterol,aspartate transaminase(AST), alanine aminotransferase(ALT) and lactate dehydrogenase(LDH) were determined by using spectrophotometer.Parameters were compared between goat and sheep.Results:It was observed that glucose(P=0.001),LDH(P=0.001) and ALT(P=0.001) concentrations differed significantly between sheep and goats.The studied parameters were compared between buck and goats and also between young goats(less than 12 months old) and adults(more than 12 months old).It was found that age and gender did not affect these hematological and serum biochemical parameters. Condusions:It can be concluded that sheep have overall higher values than goals for studied hematological and serum biochemical parameters.
Cigarette smoking is common in societies worldwide and has been identifi ed as injurious to human health. Nicotine is the most abundant component in the cigarette smoke. It is fi rst metabolized in the liver. The natural diet contains a variety of compounds, such as date palm(Phoenix dactylifera L.). It exhibits protective effect against different toxins. The aims of present study were to investigate the damaging effects of nicotine on the liver and the preventive role of date palm against such damage. Date palm pit powder was used to study its protective effect on nicotine induced hepatotoxicity. Three groups of adult male albino mice were used, each containing eight animals. Group A served as a control; Group B was used as an experimental group treated with nicotine(0.3 mg/kg) intraperitoneally for forty-fi ve days; Group C received nicotine(0.3 mg/kg) intraperitoneally along with date palm pit powder(500 mg/kg) orally for forty-five days. Histopathological examination revealed that the general architecture was damaged with increase in size of hepatocytes, central vein and number of fat vacuoles and periportal infiltration of lymphocytes. The nicotine treated mice showed decreased level of cytoplasmic vacuolization, necrosis and infl ammation. Date palm pit powder administration to nicotine-treated mice showed reversion of the damaged feature to nearly normal. These results along with previous study suggest that date palm pit powder is useful in combating nicotine induced hepatotoxicity.
A Non-Uniform Discrete-Multitone(DMT) transceiver can help mitigate the channel-noise enhancement,attributed to zero-forcing equalization (ZFE) technique,by splitting the channel frequency response into octave spaced subbands.This paper presents a novel quantitative analys is of the channel-noise enhancement in different subbands of the Non-Uniform DMT system.In order to improve the bit error rate(BER) performance,a modified Non-Uniform DMT transceiver is proposed.The BER performance of the modified Non-Uniform DMT system is compared with that of the Non-Uniform DMT and conventional DMT systems in a Digital Subscriber Line(DSL).
Objective: To determine the risk factors and outcome of acute poisoning in children at a tertiary care hospital of Karachi.
Study design: Cross sectional study
Place and duration of study: Department of Emergency Medicine, Dr Ziauddin Hospital, Karachi, Pakistan. From January 2019 to January 2021
Methodology: The patients (n=136) were selected of either gender with the precise age group of twelve years. All the patients selected were meeting the inclusion criteria and enrolled with a history of poisoning exposure within 24 hours of arriving at the hospital's emergency department. The name of the toxin, the time since ingestion of the toxic substance, factors prompting coincidental harming like age, ill-advised capacity of hurtful specialists, for example, lamp oil and blanch in soda bottles, simple access of kids to meds utilized by different individuals from the family, mother's schooling, working moms, financial status were completely assembled from the guardians or orderlies as referenced in the Performa. In general, people were poisoned primarily from within their own homes. Non-accidental poisoning cases were omitted. SPSS version 22 was used to analyze the data.
Results: Out of 136 patient enrolled in this study mean age was 5.2+2.9 years, 77(56.6%) were male and 59(43.4%) were female and mean time of presentation was 2.3+1.7 hours. Most common risk factor was unsafe storage of chemicals (n=98) (72.1%), followed by education level of mother (n=)65 (47.8%), inadequate supervision of child (n=60) (44.1%), non authorative parenting (n=51) (37.5%), working mothers (n=41) (30.1%), lack of family support (n=30) (22.1%), developmental delay (n=11) (8.1%) and poisonous plant in home garden (n=6) (4.4%). Outcome mainly depends upon type of poisoning and time interval between poisoning and presentation to the hospital, 26 (19.11%) were discharged safely from ER, while 45 (33.08%) admit in wards and 48 (35.29%) were admitted in Intensive Care and 17 (12.5%) were expired in ER.
Conclusion: In this study we have concluded that number of accidental poisoning are often occur in toddler and school going children. The major risk factor of acute poisoning found was unsafe storage or easy accessibility of house hold chemicals, second one was low level of education of parents, than non-authorative parenting, and working mothers and lack of family support. The outcome mainly depend upon time interval from ingestion of poison to presentation at hospital and type poisonous agent taken, that can lead to the need of specialized care, prolong hospital stay and sometimes results in death of a child.
Hepatitis C virus(HCV)is a global health concern which is responsible for most of the liver diseases.Currently,there is no vaccine available for prevention of HCV infection due to the high degree of strain variation.The current standard of care is a combination of pegylated interferonαwith ribavirin and boceprevir/telaprevir.This treatment was partially effective and had significant side effects.Hence,there is a need to develop new antiviral agents that interfere with different stages of the HCV life cycle.Recent advances in the understanding of both the cellular and molecular mechanisms of HCV replication have provided the basis for novel therapeutic strategies.Several hundred plant species and their phyto-constituents have been isolated for screening against HCV,and some have been shown to have great medicinal value in preventing and/or ameliorating viral diseases in pre-clinical and clinical trials.This review summarizes medicinal plants and their phytochemicals which inhibit different stages of HCV life cycle and discuss their potential use in HCV therapy.
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