Gastric outlet obstruction is a clinical syndrome characterized by epigastric abdominal pain due to mechanical occlusion and postprandial vomiting. An 82-year-old male patient applied to the emergency service with nausea, vomiting and abdominal pain. The patient with amylase elevation was admitted with pre-diagnosis of acute pancreatitis. However, pancreas parenchyma was normal in abdominal CT. A giant gastric polyp causing gastric outlet obstruction was detected in endoscopy which was decided after duodenal wall thickening. Tubular adenoma with high grade dysplasia was detected in biopsy. Here, we aim to present a case of gastric polyp that can rarely cause gastric outlet obstruction.
Huzursuz bacak sendromu (HBS) bacaklarda hareket etme dürtüsü ile kendini gösteren, şikayetlerin istirahatte arttığı, bacaklarda rahatsızlık veren duyumlar ile karakterize uyku ilişkili bir hastalık olarak tanımlanmış nörolojik duyusal-motor bir bozukluktur. Hastalığın primer (idiyopatik) HBS ve sekonder (semptomatik) HBS olmak üzere iki formu vardır. İdiopatik form genetik ve kaynağı bilinmeyen etyolojik nedenleri içerirken, sekonder formun çok çeşitli sebepleri olabilir. Sekonder HBS’nin etiyolojik sebepleri değerlendirildiğinde %43’ ünün anemi ile birlikte veya anemi olmaksızın sistemik demir eksikliği ilişkili olduğu tespit edilmiştir. Bu yazıda; son 2 yılda 8 kez tam kan bağışında bulunan ve ferritin düşüklüğüne atfedilen sekonder HBS‘ lu bir olgumuzu sunduk.
Kikuchi-Fujimoto hastalığı veya histiyositik nekrotizan lenfadenit nadir görülen bir lenfadenit nedenidir ve kendi kendini sınırlayan benign bir seyir göstermektedir. Servikal bölgede lenfadenopati ve ateş ile karakterizedir. Kesin tanı, lenf bezi biyopsisinde histiyositik nekrotizan lenfadenitin gösterilmesiyle konulmaktadır. Histopatolojik olarak tüberküloz, sistemik lupus eritematozus, lenfomalar ve reaktif lenfadenitlerle karışabilmektedir. Bu çalışmada, yüksek ateş ve servikal lenfadenomegali nedeni ile tetkik edilen ve servikal lenf bezi biyopsisi ile Kikuchi-Fujimoto hastalığı tanısı koyduğumuz genç bir bayan hastayı nadir bir durum olması nedeni ile literatür bilgileri eşliğinde kullanarak tartışılmıştır.
Sjögren sendromu; lakrimal ve oküler bezleri tutan, sikka sendromunun kardinal semptomları olan ağız ve göz kuruluğu ile seyreden sistemik otoimmün inflamatuar bir hastalıktır. Sjögren sendromu tüm gastrointestinal sistemi değişik derecelerde tutabilmektedir. Pankreatik tutulum sonucu sıklıkla akut ya da kronik pankreatit gelişmektedir. Bu çalışmada, karın ağrısı ile başvuran pankreatit kliniği takibinde, Sjögren sendromu tanısı konulan bir olgunun sunulması amaçlanmıştır.
A plasmacytoma is a myelomatous mass that can develop into a widespread illness, be seen alone, or be combined with multiple myeloma (MM). Bone marrow does not always indicate MM, but over the course of 4-5 years, about 50% of cases advance to this disease. In this study, we aimed to present a patient who was diagnosed with multiple myeloma and developed giant plasmacytoma despite bone marrow response during follow-up. During the 4th cycle, a giant plasmacytoma developed at the patient's right arm proximal humerus level.Ultrasound imaging performed on the right upper extremity was reported as 'Diffuse skin-subcutaneous thickness, increased echogenicity and linear fluid areas were observed. A large 5 × 3 cm hypoechoic nodular lesion with markedly increased blood flow was observed in the proximal medial neighborhood of the patient's incision line. Plasmacytoma continued to shrink with radiotherapy and chemotherapy At the time of diagnosis, EPs are seen in around 7% of individuals with MM and are best identified by PET/CT scans; the presence of EP is linked to a worse prognosis. Later in the course of the disease, 6% more patients will get EP. Large, crimson-colored, subcutaneous masses can be a symptom of EP. The creases on the palms and/or soles may be affected by plane xanthomas, which may be a paraneoplastic condition. Rarely, cutaneous spicules made partially of the monoclonal (M) protein may form. Results We presented a case that developed a giant plasmacytoma based on multiple myeloma. This case is important because, after the diagnosis, a giant plasmacytoma developed during the 4th cycle of chemotherapy, although the patient's laboratory examinations and clinic responded to chemotherapy after 3 cycles of chemotherapy.
Introduction Carbamazepine is an antiepileptic drug used in the treatment of epilepsy, trigeminal neuralgia, and bipolar disorder. Hematological effects that may develop with this anticonvulsant; agranulocytosis, thrombocytopenia, leukopenia, aplastic anemia, eosinophilia, or pancytopenia. Case report In this article, we wanted to present a case diagnosed with acute lymphoblastic leukemia after long-term use of carbamazepine because of epilepsy. Management and outcome Bone marrow smear was evaluated and blastic cell infiltration was observed. The carbamazepine treatment was discontinued and standard chemotherapy was started for acute lymphoblastic leukemia (CALGB protocol). Levetiracetam was started for epilepsy. Discussion Carbamazepine is an iminostilbene derivative. Carbamazepine is an antiepileptic drug that exhibits a number of side effects such as headache, abdominal pain, high blood pressure, as well as hematological disorders. In addition to causing thrombocytopenia, hypogammaglobulinemia, leukopenia, and neutropenia, it can have serious effects such as agranulocytosis, aplastic anemia, pure red cell aplasia, leukemia, or DRESS syndrome. The incidence of serious side effects from carbamazepine pharmacotherapy is low, and their exact mechanism of action is still unknown.