DEVELOPMENT OF GIANT PLASMACYTOMA IN A PATIENT WITH BONE MARROW RESPONSE DURING TREATMENT: A CASE REPORT
0
Citation
0
Reference
10
Related Paper
Abstract:
A plasmacytoma is a myelomatous mass that can develop into a widespread illness, be seen alone, or be combined with multiple myeloma (MM). Bone marrow does not always indicate MM, but over the course of 4-5 years, about 50% of cases advance to this disease. In this study, we aimed to present a patient who was diagnosed with multiple myeloma and developed giant plasmacytoma despite bone marrow response during follow-up. During the 4th cycle, a giant plasmacytoma developed at the patient's right arm proximal humerus level.Ultrasound imaging performed on the right upper extremity was reported as 'Diffuse skin-subcutaneous thickness, increased echogenicity and linear fluid areas were observed. A large 5 × 3 cm hypoechoic nodular lesion with markedly increased blood flow was observed in the proximal medial neighborhood of the patient's incision line. Plasmacytoma continued to shrink with radiotherapy and chemotherapy At the time of diagnosis, EPs are seen in around 7% of individuals with MM and are best identified by PET/CT scans; the presence of EP is linked to a worse prognosis. Later in the course of the disease, 6% more patients will get EP. Large, crimson-colored, subcutaneous masses can be a symptom of EP. The creases on the palms and/or soles may be affected by plane xanthomas, which may be a paraneoplastic condition. Rarely, cutaneous spicules made partially of the monoclonal (M) protein may form. Results We presented a case that developed a giant plasmacytoma based on multiple myeloma. This case is important because, after the diagnosis, a giant plasmacytoma developed during the 4th cycle of chemotherapy, although the patient's laboratory examinations and clinic responded to chemotherapy after 3 cycles of chemotherapy.Keywords:
Echogenicity
A Case of Multiple Myeloma Presenting with Plasmacytoma of Body of Sphenoid Bone: A Case Report Plasmacytoma (plasma cell neoplasm) presented as multiple myeloma, solitary plasmacytoma of bone (SBP) and extramedullary plasmacytoma (EMP). Types of plasmacytoma vary from one another in terms of clinical findings, treatment options and survival. Intracranial involvement of multiple myeloma is extremely rare event and rarely the first presentation of Multiple myeloma. A case of 58 years old patient reported with an unusual clinical presentation and behaviour of multiple myeloma where intracranial lesion arising from body of sphenoid. Initial biopsy proved plasmacytoma and later confirmed the case as multiple myeloma. Patient received palliative radiation and planned to receive chemotherapy. Hence, in any skull based lesion, multiple myeloma should be kept in the differential diagnosis.
Plasma cell neoplasm
Cite
Citations (2)
PLASMACYTOMA is a term used indiscriminately for plasma-cell accumulations, inflammatory as well as neoplastic in nature and benign as well as malignant in character.26Multiple myeloma is the most frequent of the plasmacytoid tumors. The problem of multiple myeloma is so intimately related to solitary plasmacytoma that some consideration of this interrelationship is necessary before proceeding to the more limited subject of solitary plasmacytoma of the upper respiratory tract and oral cavity. Multiple myeloma is recognized as a frequent and rapidly fatal disease of bone originating in the medulla, or bone marrow, that is active in hemopoiesis.23One school of thought, however, considers it as an intrinsic disease of the blood-forming structures generally. The disease is characterized by multiple osteolytic foci in the involved bones. These foci are composed of plasma-cell masses. Multiple myeloma is, as a rule, so rapidly progressive that death ensues within two years. In
Plasma cell neoplasm
Respiratory tract
Cite
Citations (14)
Objective: to study trends of multiple myeloma and plasmacytoma in Basrah as a model of Asian countries and compare the results with those of western records. Methods: retrospective review of 102 cases of multiple myeloma and plasmacytoma of both sexes registered in Basrah through the years 1996-2010 regarding their demographic features the collected dated tabulated and analyzed. Results: a total of 102 patient, 62 males and 40 females with a median age for males 56 years and for females 55 years multiple myeloma represented 92.2% of total cases while plasmacytoma represented 7.8%. Conclusion: -Incidence rate of multiple myeloma and plsmacytoma in eastern countries seems comparable to incidence rate in eastern countries but the incidence is low when compared to western statistics. -Multiple myeloma and plasmacytoma showed no significant changes through the last 15 years.
Cite
Citations (0)
Multiple myeloma is a malignant proliferation of the plasma cells mainly affecting bone marrow, but other organs may also be involved.Multiple myeloma is rarely associated with lung plasmacytoma.Patients with extramedullary plasmacytomas have coexistent multiple myeloma in only 5% of cases.The incidence of malignant pleural effusion in multiple myeloma is very low and is approximately 1%.In this case series, we report three patients with multiple myeloma, who presented with different thoracic manifestations such as left-sided myelomatous pleural effusion, posterior mediastinal mass with central airway obstruction, and pulmonary consolidation.
Cite
Citations (5)
The prognosis of solitary plasmacytoma varies greatly, with some patients recovering after surgical removal or local fractional radiation therapy, and others progressing to multiple myeloma years later. Primary detection of progression to multiple myeloma is important in the treatment of solitary plasmacytoma. There have been several analyses of the risk factors involved in the early progression to multiple myeloma. We describe one case of solitary plasmacytoma of the lumbar vertebra that was treated with surgical decompression with stabilization and additional radiotherapy. The patient had no factors associated with rapid progression to multiple myeloma such as age, size, immunologic results, pathological findings, and serum free light chain ratio at the time of diagnosis. However, his condition progressed to multiple myeloma less than two months after the initial diagnosis of solitary plasmacytoma. We suggest that surgeons should be vigilant in watching for rapid progression to multiple myeloma even in case that the patient with solitary plasmacytoma has no risk factors for rapid progression to multiple myeloma.
Vertebra
Cite
Citations (19)
Extramedullary plasmacytoma of the pancreas is a rare entity.Although this condition is uncommon, it should be considered in the differential diagnosis of solid mass in the pancreas, especially in patients with underlying multiple myeloma.We report a case of pancreatic plasmacytoma in a 56-year-old woman with newly diagnosed multiple myeloma.We highlight this rare manifestation of multiple myeloma among other better recognised presentations.
Extramedullary plasmacytoma
Cite
Citations (7)
Plasma cell dyscrasias are characterized by neoplastic proliferation of a single clone of plasma cells typically producing a monoclonal immunoglobulin. Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) or more commonly as multiple lesions (multiple myeloma). Plasmacytomas can be present at the initial diagnosis of multiple myeloma or develop later during the course of the disease.
When plasmacytoma is associated with 10 percent or more clonal plasma cells in the bone marrow, the diagnosis is considered to be multiple myeloma rather than solitary plasmacytoma. While solitary plasmacytomas are treated with radiotherapy, multiple myeloma is treated with chemotherapy.
Plasma cell neoplasm
Plasma cell dyscrasia
Dyscrasia
Myeloma protein
clone (Java method)
Plasma Cell Myeloma
Cite
Citations (0)
Extramedullary plasmacytoma is a rare complication of multiple myeloma (MM). Compared with bone-restricted MM, the prognosis of MM with extramedullary plasmacytoma is poor and even novel agent contained treatment cannot overcome it. This paper reviews the advances in MM with extramedullary plasmacytoma from following four aspects, incidence, pathogenesis, clinical manifestation, treatment and prognosis.
Key words:
Multiple myeloma; Plasmacytoma; Incidence; Therapeutics; Prognosis; Extramedullary plasmacytoma
Extramedullary plasmacytoma
Cite
Citations (0)
Multiple myeloma is described by the proliferation of malignant plasma cells, in which orbital involvement is rare. In this report, we collected all cases with orbital multiple myeloma from 2009 to 2018 and investigated the characteristics such as sex, age, common orbital symptoms, unilateral or bilateral and different therapeutic options. Also, we reported an uncommon case of multiple myeloma that has been developed into plasmacytoma. Our patient had been initially diagnosed with multiple myeloma, but after a few months, the disease had progressed to secondary extramedullary plasmacytoma in the retrobulbar. Therapeutic measures, such as surgery to prevent its development in the patient's eye, were successful.
Extramedullary plasmacytoma
Cite
Citations (3)
Malignant myeloma (MM) is a clonal proliferation of plasma cells with multiple osteolytic lesions. Extramedullary dissemination of multiple myeloma in lung is relatively uncommon. Hereby, we present a case of multiple myeloma with lung plasmacytoma of lung in a 45-years-old, non-smoker, female.
Extramedullary plasmacytoma
Plasma Cell Myeloma
Cite
Citations (14)