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David Blocquel
David Blocquel
Scripps Research Institute
Mutation
Transfer RNA
Biology
Genetics
Mutant
6
Papers
104
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CMT2N-causing aminoacylation domain mutants enable Nrp1 interaction with AlaRS.
2021
Proceedings of the National Academy of Sciences of the United States of America
Litao Sun
Na Wei
Bernhard Kuhle
David Blocquel
Scott J. Novick
Żaneta Matuszek
Huihao Zhou
Weiwei He
Jingjing Zhang
Thomas Weber
Rita Horvath
Philippe Latour
Tao Pan
Paul Schimmel
Patrick R. Griffin
Xiang-Lei Yang
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Citations (1)
CMT disease severity correlates with mutation-induced open conformation of histidyl-tRNA synthetase, not aminoacylation loss, in patient cells
2019
Proceedings of the National Academy of Sciences of the United States of America
David Blocquel
Litao Sun
Żaneta Matuszek
Sheng Li
Thomas Weber
Bernhard Kuhle
Grace Kooi
Na Wei
Jonathan Baets
Tao Pan
Paul Schimmel
Xiang-Lei Yang
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Citations (16)
Transcriptional dysregulation by a nucleus-localized aminoacyl-tRNA synthetase associated with Charcot-Marie-Tooth neuropathy
2019
Nature Communications
Sven Bervoets
Na Wei
Maria-Luise Erfurth
Shazie Yusein-Myashkova
Biljana Ermanoska
Ligia Mateiu
Bob Asselbergh
David Blocquel
Priyanka Kakad
Tyrone Penserga
Florian P. Thomas
Velina Guergueltcheva
Ivailo Tournev
Tanja A. Godenschwege
Albena Jordanova
Xiang-Lei Yang
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Citations (11)
Two crystal structures reveal design for repurposing the C-Ala domain of human AlaRS
2016
Proceedings of the National Academy of Sciences of the United States of America
Litao Sun
Youngzee Song
David Blocquel
Xiang-Lei Yang
Paul Schimmel
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Citations (11)
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