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Bethan A. Cole
Bethan A. Cole
University of Leeds
Potassium channel
hERG
Quinidine
Pharmacophore
Chemistry
4
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5
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0
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Epilepsy-causing KCNT1 variants increase KNa1.1 channel activity by disrupting the activation gate.
2021
bioRxiv
Bethan A. Cole
Nadia Pilati
Jonathan D. Lippiat
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Targeting KNa1.1 channels in KCNT1-associated epilepsy.
2021
Trends in Pharmacological Sciences
Bethan A. Cole
Steven J. Clapcote
Stephen P. Muench
Jonathan D. Lippiat
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Structure based identification and characterisation of inhibitors of the epilepsy associated KNa1.1 (KCNT1) potassium channel
2020
iScience
Bethan A. Cole
Rachel M. Johnson
Hattapark Dejakaisaya
Nadia Pilati
Colin W. G. Fishwick
Stephen P. Muench
Jonathan D. Lippiat
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Structure-based identification and characterisation of novel inhibitors of KNa1.1 potassium channels, a stratified target for KCNT1-related epilepsy.
2019
bioRxiv
Bethan A. Cole
Rachel M. Johnson
Hattapark Dejakaisaya
Nadia Pilati
Colin W. G. Fishwick
Stephen P. Muench
Jonathan D. Lippiat
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