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Siva Lavu

Harvard University

17

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Pharmacokinetics and tolerability of SRT2104, a first‐in‐class small molecule activator of SIRT1, after single and repeated oral administration in man

2013 British Journal of Clinical Pharmacology
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Discovery of thieno[3,2-d]pyrimidine-6-carboxamides as potent inhibitors of SIRT1, SIRT2, and SIRT3.

2013 Journal of Medicinal Chemistry
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Discovery of oxazolo[4,5-b]pyridines and related heterocyclic analogs as novel SIRT1 activators

2009 Bioorganic & Medicinal Chemistry Letters
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Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo.

2009 BMC Systems Biology
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Resveratrol/SRT-501

2009 Drugs of The Future
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Erratum: Sirtuins — novel therapeutic targets to treat age-associated diseases

2009 Nature Reviews Drug Discovery
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Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes.

2007 Nature
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Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors.

2005 Journal of Medicinal Chemistry
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Acetylation of the C terminus of Ku70 by CBP and PCAF controls bax-mediated apoptosis

2004 Molecular Cell
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Sirtuin activators mimic caloric restriction and delay ageing in metazoans

2004 Nature
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Citations (1616)