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Douglas K. Spracklin
Douglas K. Spracklin
University of Washington
Chemistry
Biochemistry
Metabolism
Metabolite
Trifluoromethyl
5
Papers
352
Citations
0.01
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Concentration-Dependent Modulation of Amyloid-β in Vivo and in Vitro Using the γ-Secretase Inhibitor, LY-450139
2006
Journal of Pharmacology and Experimental Therapeutics
Thomas A. Lanz
Michael J. Karmilowicz
Kathleen M. Wood
Nikolay Pozdnyakov
Ping Du
Mary A. Piotrowski
Tracy M. Brown
Charles E. Nolan
Karl E.G. Richter
James E. Finley
Qing-fei
Charles F. Ebbinghaus
Yuhpyng L. Chen
Douglas K. Spracklin
Barbara Tate
Kieran F. Geoghegan
Lit-Fui Lau
David D. Auperin
Joel B. Schachter
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Citations (133)
Dose-dependent metabolism of fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A), an anesthetic degradation product, to mercapturic acids and 3,3,3-trifluoro-2-(fluoromethoxy)propanoic acid in rats.
1999
Toxicology and Applied Pharmacology
Evan D. Kharasch
Carole Jubert
Douglas K. Spracklin
Gary M. Hoffman
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Citations (15)
Cytochrome P450 2E1 is the Principal Catalyst of Human Oxidative Halothane Metabolism in Vitro
1997
Journal of Pharmacology and Experimental Therapeutics
Douglas K. Spracklin
Douglas C. Hankins
Jeannine M. Fisher
Kenneth E. Thummel
Evan D. Kharasch
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Citations (113)
Human reductive halothane metabolism in vitro is catalyzed by cytochrome P450 2A6 and 3A4.
1996
Drug Metabolism and Disposition
Douglas K. Spracklin
Kenneth E. Thummel
Evan D. Kharasch
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Citations (49)
Evidence for metabolism of fluoromethyl 2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A), a sevoflurane degradation product, by cysteine conjugate beta-lyase.
1996
Chemical Research in Toxicology
Douglas K. Spracklin
Evan D. Kharasch
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Citations (42)
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