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Mathew P. Leese

University of Bath

47

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The In Vitro and In Vivo Activity of the Microtubule Disruptor STX140 Is Mediated by Hif-1 Alpha and CAIX Expression

2015 Anticancer Research
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Targeted NF1 cancer therapeutics with multiple modes of action: small molecule hormone-like agents resembling the natural anticancer metabolite, 2-methoxyoestradiol.

2015 British Journal of Cancer
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Synthesis, anti-tubulin and antiproliferative SAR of steroidomimetic dihydroisoquinolinones

2014 ChemMedChem
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Cover Picture: Tetrahydroisoquinolinone-Based Steroidomimetic and Chimeric Microtubule Disruptors (ChemMedChem 1/2014)

2014 ChemMedChem
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Synthesis, antitubulin, and antiproliferative SAR of C3/C1-substituted tetrahydroisoquinolines.

2014 ChemMedChem
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Steroidomimetic Tetrahydroisoquinolines for the Design of New Microtubule Disruptors.

2012 ACS Medicinal Chemistry Letters
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Structure–Activity Relationships of C-17-Substituted Estratriene-3-O-sulfamates as Anticancer Agents

2011 Journal of Medicinal Chemistry
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Abstract 756: Optimization of tetrahydroisoquinoline-based microtubule disruptors as anticancer agents

2010 Cancer Research
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A chimeric microtubule disruptor with efficacy on a taxane resistant cell line

2010
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Synthesis, Antitubulin, and Antiproliferative SAR of Analogues of 2-Methoxyestradiol-3,17-O,O-bis-sulfamate

2010 Journal of Medicinal Chemistry
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Citations (37)