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Andrew McPherson

Isis Pharmaceuticals

19

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586

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Synthesis of 5′-GalNAc-Conjugated Oligonucleotides: A Comparison of Solid and Solution-Phase Conjugation Strategies

2017 Molecules
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Formation of the N2-acetyl-2,6-diaminopurine oligonucleotide impurity caused by acetyl capping

2014 Bioorganic & Medicinal Chemistry Letters
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Development of novel benzotriazines for drug discovery

2009 Expert Opinion on Drug Discovery
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Development of prodrug 4-chloro-3-(5-methyl-3-{[4-(2-pyrrolidin-1-ylethoxy) phenyl]amino}-1,2,4-benzotriazin-7-yl)phenyl benzoate (TG100801): A topically administered therapeutic candidate in clinical trials for the treatment of age-related macular degeneration

2008 Journal of Medicinal Chemistry
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Topical Dual VEGF Receptor/Src Kinase Inhibitors as Potential Therapies for Ischemic Retinal Vascular Disorders

2008 The FASEB Journal
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Composés de pyrrolopyrimidine et leur utilisation en tant qu'inhibiteurs des janus kinases

2008
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Targeting Drug Resistant Mutations Using Novel Binding Interactions - Lessons Learned from Abl-T315I and their Implications in D

2007
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Discovery of [7-(2,6-dichlorophenyl)-5-methylbenzo [1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-ylethoxy)phenyl]amine—a potent, orally active Src kinase inhibitor with anti-tumor activity in preclinical assays

2007 Bioorganic & Medicinal Chemistry Letters
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Metabolism and pharmacokinetics of a novel Src kinase inhibitor TG100435 ([7-(2,6-dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine) and its active N-oxide metabolite TG100855 ([7-(2,6-dichloro-phenyl)-5-methylbenzo[1,2,4]triazin-3-yl]-{4-[2-(1-oxy-pyrrolidin-1-yl)-ethoxy]-phenyl}-amine).

2007 Drug Metabolism and Disposition
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Discovery and preliminary structure–activity relationship studies of novel benzotriazine based compounds as Src inhibitors

2006 Bioorganic & Medicinal Chemistry Letters
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Citations (23)