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J.M. Jenson

Massachusetts Institute of Technology

6

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Tertiary Structural Motif Sequence Statistics Enable Facile Prediction and Design of Peptides that Bind Anti-apoptotic Bfl-1 and Mcl-1

2019 Structure
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Crystal structure of human Mcl-1 in complex with modified Bim BH3 peptide SAH-MS1-14

2018
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Crystal structure of human Mcl-1 in complex with modified Bim BH3 peptide SAH-MS1-18

2018
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Iterative optimization yields Mcl-1-targeting stapled peptides with selective cytotoxicity to Mcl-1-dependent cancer cells

2018 Proceedings of the National Academy of Sciences of the United States of America
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Epistatic mutations in PUMA BH3 drive an alternate binding mode to potently and selectively inhibit anti-apoptotic Bfl-1.

2017 eLife
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