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Cydney M. Martell

Kalamazoo College

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P134 - Evaluation of CRISPR-CAS9 and CRISPR-CAS13 in modulating drug metabolizing enzymes

2020 Drug Metabolism and Pharmacokinetics
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CYP2D6 allelic variants *34, *17-2, *17-3, and *53 and a Thr309Ala mutant display altered kinetics and NADPH coupling in metabolism of bufuralol and dextromethorphan and altered susceptibility to inactivation by SCH 66712

2018 Drug Metabolism and Disposition
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Allelic variants of CYP2D6 have altered drug metabolite profile, kinetics, and susceptibility to mechanism-based inactivation

2018 Drug Metabolism and Pharmacokinetics
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