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Frédéric Knoflach

Hoffmann-La Roche

60

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2383

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Basmisanil, a highly selective GABA A -α5 negative allosteric modulator: preclinical pharmacology and demonstration of functional target engagement in man

2021 Scientific Reports
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Tonic GABAergic activity facilitates dendritic calcium signaling and short-term plasticity

2020 bioRxiv
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Enhanced dendritic inhibition and impaired NMDAR activation in a mouse model of Down syndrome

2019 The Journal of Neuroscience
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Dendrite-targeting interneurons control synaptic NMDA-receptor activation via nonlinear α5-GABA A receptors

2018 Nature Communications
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Parvalbumin expression and gamma oscillation occurrence increase over time in a neurodevelopmental model of NMDA receptor dysfunction

2018 PeerJ
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Identification of a Corticohabenular Circuit Regulating Socially Directed Behavior

2017 Biological Psychiatry
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GABAA receptor-mediated neurotransmission: Not so simple after all

2016 Biochemical Pharmacology
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RG1662, a Selective GABAA α5 Receptor Negative Allosteric Modulator, Increases Gamma Power in Young Adults with Down Syndrome. (P6.273)

2015 Neurology
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Long-Term Cultivation and Recording from Organotypic Brain Slices on High-density Micro-electrode Arrays

2014
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Mapping the binding pocket of a novel, high-affinity, slow dissociating tachykinin NK3 receptor antagonist: biochemical and electrophysiological characterization.

2014 Neuropharmacology
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