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Nuruddeen D. Lewis

Vanderbilt University Medical Center

35

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ExoSTING, an extracellular vesicle loaded with STING agonists, promotes tumor immune surveillance.

2021
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709 Exosome surface display of IL-12 results in tumor-retained pharmacology with superior potency and limited systemic exposure

2020 Journal for ImmunoTherapy of Cancer
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Exosome surface display of IL-12 results in tumor-retained pharmacology with superior potency and limited systemic exposure compared to recombinant IL-12

2020 Molecular Cancer Therapeutics
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703 Engineered exosomes with altered cellular tropism achieve targeted STING agonist delivery and single-agent tumor control in vivo

2020 Journal for ImmunoTherapy of Cancer
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Abstract 944: exoSTING: An engineered exosome therapeutic that selectively delivers STING agonist to the tumor resident antigen-presenting cells resulting in improved tumor antigen-specific adaptive immune response

2019 Immunology
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1 Arginase II Deletion Enhances Pro-Inflammatory Macrophage Activation and Polyamine Metabolism in Response to Helicobacter pylori

2016 Gastroenterology
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Arginase 2 deletion leads to enhanced M1 macrophage activation and upregulated polyamine metabolism in response to Helicobacter pylori infection.

2016 Amino Acids
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Deletion of cationic amino acid transporter 2 exacerbates dextran sulfate sodium colitis and leads to an IL-17-predominant T cell response

2013 American Journal of Physiology-gastrointestinal and Liver Physiology
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Novel insights into the effects of spingosine-1-phosphate receptor modulators on monocytes

2012 Journal of Immunology
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Immune Evasion by Helicobacter pylori Is Mediated by Induction of Macrophage Arginase II

2011 Journal of Immunology
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Citations (57)