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Olivier Lepage
Olivier Lepage
Boehringer Ingelheim
Chemistry
Stereochemistry
NS5B
Potency
Polymerase
4
Papers
72
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Molecular Dynamics Simulations and Structure-Based Rational Design Lead to Allosteric HCV NS5B Polymerase Thumb Pocket 2 Inhibitor with Picomolar Cellular Replicon Potency.
2014
Journal of Medicinal Chemistry
Oliver Hucke
René Coulombe
Pierre R. Bonneau
Megan Bertrand-Laperle
Christian Brochu
James Gillard
Marc-André Joly
Serge Landry
Olivier Lepage
Montse Llinas-Brunet
Marc Pesant
Martin Poirier
Ginette McKercher
Martin Marquis
George Kukolj
Pierre L. Beaulieu
Timothy Stammers
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Citations (19)
Discovery and Structural Characterization of a New Inhibitor Series of HIV-1 Nucleocapsid Function: NMR Solution Structure Determination of a Ternary Complex Involving a 2:1 Inhibitor/NC Stoichiometry.
2013
Journal of Molecular Biology
Nathalie Goudreau
Oliver Hucke
Anne-Marie Faucher
Chantal Grand-Maitre
Olivier Lepage
Pierre R. Bonneau
Stephen W. Mason
Steve Titolo
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Citations (37)
Structure-based design of novel HCV NS5B thumb pocket 2 allosteric inhibitors with submicromolar gt1 replicon potency: Discovery of a quinazolinone chemotype
2013
Bioorganic & Medicinal Chemistry Letters
Pierre L. Beaulieu
René Coulombe
Jianmin Duan
Gulrez Fazal
Cédrickx Godbout
Oliver Hucke
Araz Jakalian
Marc-André Joly
Olivier Lepage
Montse Llinas-Brunet
Julie Naud
Martin Poirier
Nathalie Rioux
Bounkham Thavonekham
George Kukolj
Timothy Stammers
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Citations (16)
Chinazolinonderivate als virenpolymerasehemmer
2010
Timothy Stammers
Xavier Barbeau
Pierre L. Beaulieu
Megan Bertrand-Laperle
Christian Brochu
Paul J. Edwards
Pasquale Forgione
Cédrickx Godbout
Oliver Hucke
Marc-André Joly
Serge Landry
Olivier Lepage
Julie Naud
Marc Pesant
Martin Poirier
Maude Poirier
Bounkham Thavonekham
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