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Mariacarmela Allocca

Massachusetts Institute of Technology

22

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Improved CRISPR genome editing using small highly active and specific engineered RNA-guided nucleases

2021 Nature Communications
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Inflammation, necrosis, and the kinase RIP3 are key mediators of AAG-dependent alkylation-induced retinal degeneration

2019 Science Signaling
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PARP inhibitors protect against sex- and AAG-dependent alkylation-induced neural degeneration

2017 Oncotarget
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ALKBH7 drives a tissue and sex-specific necrotic cell death response following alkylation-induced damage

2017 Cell Death and Disease
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Necroptosis mediates alkylation-induced retinal degeneration in mouse

2016 Investigative Ophthalmology & Visual Science
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Aag-initiated base excision repair promotes ischemia reperfusion injury in liver, brain, and kidney

2014 Proceedings of the National Academy of Sciences of the United States of America
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AAV-Mediated Gene Replacement, Either Alone or in Combination with Physical and Pharmacological Agents, Results in Partial and Transient Protection from Photoreceptor Degeneration Associated with βPDE Deficiency

2011 Investigative Ophthalmology & Visual Science
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Gene Therapy of a Mouse Model of Stargardt's Disease Using Adeno-Associated Viral Vectors Packaging Large Genes

2008 Investigative Ophthalmology & Visual Science
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Novel Adeno-Associated Virus Serotypes Efficiently Transduce Murine Photoreceptors

2007 Journal of Virology
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Constitutive and AP20187-Induced Ret Activation in Photoreceptors Does Not Protect from Light-Induced Damage

2007 Investigative Ophthalmology & Visual Science
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