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Cen Guo
Cen Guo
University of North Carolina at Chapel Hill
Chemistry
Transporter
Biochemistry
Pharmacology
Efflux
6
Papers
81
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Hepatic Transporter Alterations by Nuclear Receptor Agonist T0901317 in Sandwich-cultured Human Hepatocytes: Proteomic Analysis and PBPK Modeling to Evaluate Drug-Drug Interaction Risk
2020
Journal of Pharmacology and Experimental Therapeutics
Katsuaki Ito
Noora Sjöstedt
Melina M. Malinen
Cen Guo
Kim L. R. Brouwer
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Citations (1)
Probe Cocktail to Assess Transporter Function in Sandwich-Cultured Human Hepatocytes
2019
Journal of Pharmacy and Pharmaceutical Sciences
Cen Guo
Kim L. R. Brouwer
Kenneth R. Brouwer
Paul W. Stewart
Caroline Mosley
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Farnesoid X receptor agonists obeticholic acid and chenodeoxycholic acid increase bile acid efflux in sandwich-cultured human hepatocytes: Functional evidence and mechanisms
2018
Journal of Pharmacology and Experimental Therapeutics
Cen Guo
Carl LaCerte
Jeffrey E. Edwards
Kenneth R. Brouwer
Kim L. R. Brouwer
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Citations (16)
Prediction of Hepatic Efflux Transporter-Mediated Drug Interactions: When Is it Optimal to Measure Intracellular Unbound Fraction of Inhibitors?
2017
Journal of Pharmaceutical Sciences
Cen Guo
Kyunghee Yang
Mingxiang Liao
Cindy Q. Xia
Kenneth R. Brouwer
Kim L. R. Brouwer
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Citations (5)
Prediction of altered bile acid disposition due to inhibition of multiple transporters: An integrated approach using sandwich-cultured hepatocytes, mechanistic modeling and simulation
2016
Journal of Pharmacology and Experimental Therapeutics
Cen Guo
Kyunghee Yang
Kenneth R. Brouwer
Robert L. St. Claire
Kim L. R. Brouwer
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Citations (15)
Sandwich-Cultured Hepatocytes as a Tool to Study Drug Disposition and Drug-Induced Liver Injury.
2016
Journal of Pharmaceutical Sciences
Kyunghee Yang
Cen Guo
Jeffrey L. Woodhead
Robert L. St. Claire
Paul B. Watkins
Scott Q. Siler
Brett A. Howell
Kim L. R. Brouwer
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Citations (44)
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