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Toshiyuki Kanemasa

37

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Preventive effects of naldemedine, peripherally acting μ-opioid receptor antagonist, on morphine-induced nausea and vomiting in ferrets.

2020 Life Sciences
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Pharmacological Profile of Naldemedine, a Peripherally Acting mu-Opioid Receptor Antagonist: Comparison with Naloxone and Naloxegol.

2020 Journal of Pharmacology and Experimental Therapeutics
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Naldemedine: Peripherally-acting Opioid Receptor Antagonist for Treating Opioid-induced Adverse Effects.

2020 Current Topics in Medicinal Chemistry
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Discovery of naldemedine: A potent and orally available opioid receptor antagonist for treatment of opioid-induced adverse effects

2019 Bioorganic & Medicinal Chemistry Letters
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Effects of Naldemedine, a Peripherally Acting μ-Opioid Receptor Antagonist, on Inhibition of Large Intestinal Transit Induced by Morphine in Rodent Models

2017 Gastroenterology
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Pharmacological evaluation of novel (6-aminopyridin-3-yl)(4-(pyridin-2-yl)piperazin-1-yl) methanone derivatives as TRPV4 antagonists for the treatment of pain

2017 Bioorganic & Medicinal Chemistry
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Discovery of novel 2',4'-dimethyl-[4,5'-bithiazol]-2-yl amino derivatives as orally bioavailable TRPV4 antagonists for the treatment of pain: Part 2.

2016 Bioorganic & Medicinal Chemistry Letters
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Discovery of novel 2',4'-dimethyl-[4,5'-bithiazol]-2-yl amino derivatives as orally bioavailable TRPV4 antagonists for the treatment of pain: Part 1.

2016 Bioorganic & Medicinal Chemistry Letters
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Sensitization of TRPV1 by protein kinase C in rats with mono-iodoacetate-induced joint pain.

2016 Osteoarthritis and Cartilage
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Dissociation Rates as One of the Differentiating Factors for Hyperthermic and Non-Hyperthermic TRPV1 Antagonists

2015 Biophysical Journal
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