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Richard Frenette

Merck & Co.

60

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1925

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Discovery of disubstituted phenanthrene imidazoles as potent, selective and orally active mPGES-1 inhibitors

2009 Bioorganic & Medicinal Chemistry Letters
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Substituted 2,2-bisaryl-bicycloheptanes as novel and potent inhibitors of 5-lipoxygenase activating protein

2008 Bioorganic & Medicinal Chemistry Letters
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2-(phenyl ou heterocyclique)-1h-phenantrho[9,10-d]imidazoles utilisees comme inhibiteurs de la mpges-1

2006
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Peripheral Phosphodiesterase 4 Inhibition Produced by 4-[2-(3,4-Bis-difluoromethoxyphenyl)-2-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-phenyl]-ethyl]-3-methylpyridine-1-oxide (L-826,141) Prevents Experimental Autoimmune Encephalomyelitis

2006 Journal of Pharmacology and Experimental Therapeutics
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Peripheral Phosphodiesterase 4 Inhibition Produced by

2006
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Lack of Clinical Efficacy of a Phosphodiesterase‐4 Inhibitor for Treatment of Heaves in Horses

2006 Journal of Veterinary Internal Medicine
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2,3-Diarylthiophenes as selective EP1 receptor antagonists

2005 Bioorganic & Medicinal Chemistry Letters
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Optimization of a tertiary alcohol series of phosphodiesterase-4 (PDE4) inhibitors: structure-activity relationship related to PDE4 inhibition and human ether-a-go-go related gene potassium channel binding affinity.

2003 Journal of Medicinal Chemistry
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Substituted aminopyridines as potent and selective phosphodiesterase-4 inhibitors

2003 Bioorganic & Medicinal Chemistry Letters
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Substituted 2-pyridinemethanol derivatives as potent and selective phosphodiesterase-4 inhibitors

2003 Bioorganic & Medicinal Chemistry Letters
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